المؤلفون: Cui, Hengjing, Elford, Joshua D., Alitalo, Okko, Perez-Pardo, Paula, Tampio, Janne, Huttunen, Kristiina M., Kraneveld, Aletta, Forsberg, Markus M., Myohanen, Timo T., Jalkanen, Aaro J.

المساهمون: Faculty of Pharmacy, Doctoral Programme in Drug Research, Divisions of Faculty of Pharmacy, PREP in neurodegenerative disorders

مصطلحات موضوعية: 6-hydroxydopamine, Alpha-synuclein, Colon, Lesion, Parkinson's disease, Rat, 317 Pharmacy

وصف الملف: application/pdf

العلاقة: Cui , H , Elford , J D , Alitalo , O , Perez-Pardo , P , Tampio , J , Huttunen , K M , Kraneveld , A , Forsberg , M M , Myohanen , T T & Jalkanen , A J 2023 , ' Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon ' , Neurobiology of Aging , vol. 129 , pp. 62-71 . https://doi.org/10.1016Test/j.neurobiolaging.2023.05.007; ORCID: /0000-0001-7446-0673/work/150702274; ORCID: /0000-0002-9277-6687/work/150721660; c793e56d-5a23-439a-b977-f415dedfc1f3; http://hdl.handle.net/10138/569345Test; 001013508200001

الإتاحة: http://hdl.handle.net/10138/569345Test

المؤلفون: Cui, Hengjing, Elford, Joshua D, Alitalo, Okko, Perez-Pardo, Paula, Tampio, Janne, Huttunen, Kristiina M, Kraneveld, Aletta, Forsberg, Markus M, Myöhänen, Timo T, Jalkanen, Aaro J

المساهمون: Afd Pharmacology, Pharmacology

مصطلحات موضوعية: 6-hydroxydopamine, Alpha-synuclein, Colon, Lesion, Parkinson's disease, Rat, Clinical Neurology, Geriatrics and Gerontology, Ageing, General Neuroscience, Developmental Biology

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/432871Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/432871Test

المؤلفون: Tonduru, Arun Kumar, Maljaei, Seyed Hamed, Adla, Santosh Kumar, Anamea, Landry, Tampio, Janne, Králová, Adéla, Jalkanen, Aaro J., Espada, Catarina, Santos, Inês Falcato, Montaser, Ahmed B., Rautio, Jarkko, Kronenberger, Thales, Poso, Antti, Huttunen, Kristiina M.

المساهمون: Bundesministerium f?r Bildung und Forschung, Sigrid Jus?liuksen S??ti, Terveyden Tutkimuksen Toimikunta, European Proteomics Infrastructure Consortium providing access, Ministerium f?r Wissenschaft, Forschung und Kunst Baden-W?rttemberg, Horizon 2020 Framework Programme

المصدر: Journal of Medicinal Chemistry ; volume 66, issue 22, page 15094-15114 ; ISSN 0022-2623 1520-4804

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01026Test

المؤلفون: Jalkanen, Aaro J., Ihalainen, Jouni, Lehtonen, Marko, Forsberg, Markus M., Rautio, Jarkko, Huttunen, Kristiina M., Gynther, Mikko

المساهمون: Suomen Kulttuurirahasto, Business Finland, Terveyden Tutkimuksen Toimikunta, Emil Aaltosen Säätiö

المصدر: International Journal of Pharmaceutics ; volume 596, page 120300 ; ISSN 0378-5173

مصطلحات موضوعية: Pharmaceutical Science

الإتاحة: https://doi.org/10.1016Test/j.ijpharm.2021.120300
https://api.elsevier.com/content/article/PII:S0378517321001046?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0378517321001046?httpAccept=text/plainTest

المؤلفون: Zhurakovskaya, Ekaterina, Leikas, Juuso, Pirttimaki, Tiina, Mon, Francesc Casas, Gynther, Mikko, Aliev, Rubin, Rantamaki, Tomi, Tanila, Heikki, Forsberg, Markus M., Gröhn, Olli, Paasonen, Jaakko, Jalkanen, Aaro J.

المساهمون: Drug Research Program, Division of Pharmacology and Pharmacotherapy, Laboratory of Neurotherapeutics

مصطلحات موضوعية: 6-OHDA lesion, connectivity, rat, resting-state fMRI, sleep, urethane, MAGNETIC-RESONANCE SPECTROSCOPY, BEHAVIOR DISORDER, REM-SLEEP, DOPAMINE, STRIATUM, LESIONS, 6-HYDROXYDOPAMINE, DEGENERATION, ACTIVATION, GLUTAMATE, 3124 Neurology and psychiatry

وصف الملف: application/pdf

العلاقة: This work was supported by Emil Aaltonen foundation (T.P.), Finnish Academy of Science and Letters (E.Z.), and the Academy of Finland (O.G.). The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. We thank Kalle Voutilainen for help with the animal experiments and DA assay, Maarit Pulkkinen for technical assistance in fMRI experiments, Jaana Leskinen for help with biochemical assays, Raimo Salo for valuable advice in data analysis, and Dr. Ewen MacDonald for the linguistic revision of this paper.; Zhurakovskaya , E , Leikas , J , Pirttimaki , T , Mon , F C , Gynther , M , Aliev , R , Rantamaki , T , Tanila , H , Forsberg , M M , Gröhn , O , Paasonen , J & Jalkanen , A J 2019 , ' Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease ' , eNeuro , vol. 6 , no. 1 , UNSP e0456-18.2019 . https://doi.org/10.1523/ENEURO.0456-18.2019Test; ORCID: /0000-0002-0052-1434/work/68614128; e2f8a271-22b6-47d3-b405-47f6b766c21b; http://hdl.handle.net/10138/311287Test; 000461453600041

الإتاحة: http://hdl.handle.net/10138/311287Test

المؤلفون: Leikas, Juuso V., Kohtala, Samuel, Theilmann, Wiebke, Jalkanen, Aaro J., Forsberg, Markus M., Rantamaki, Tomi

المساهمون: Biosciences, Laboratory of Neurotherapeutics

مصطلحات موضوعية: anesthesia, dopamine, neurodegeneration, phosphorylation, sensorimotor test, GLYCOGEN-SYNTHASE KINASE-3, ELECTROCONVULSIVE SHOCK, ALPHA-SYNUCLEIN, PATHWAY, BRAIN, NEUROPROTECTION, HIPPOCAMPUS, INHIBITION, 1182 Biochemistry, cell and molecular biology, 3112 Neurosciences

وصف الملف: application/pdf

العلاقة: The authors thank Dr. Claudia Brandt and Virpi Perko for technical assistance. Dr. Giuseppe P. Cortese is thanked for language editing and his constructive comments on the manuscript. This study has been supported by grants from the Academy of Finland (T.R.; grants: 276333, 284569). Authors declare no conflict of interest related to this manuscript.; Leikas , J V , Kohtala , S , Theilmann , W , Jalkanen , A J , Forsberg , M M & Rantamaki , T 2017 , ' Brief isoflurane anesthesia regulates striatal AKT-GSK3 beta signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease ' , Journal of Neurochemistry , vol. 142 , no. 3 , pp. 456-463 . https://doi.org/10.1111/jnc.14066Test; ORCID: /0000-0002-0052-1434/work/39203845; ORCID: /0000-0001-9249-085X/work/39206248; 85020713384; cfc2f9f1-1657-4a35-b3f4-083d7db05295; http://hdl.handle.net/10138/248407Test; 000405768400010

الإتاحة: http://hdl.handle.net/10138/248407Test

المؤلفون: Natunen, Teemu A, Gynther, Mikko, Rostalski, Hannah, Jaako, Külli, Jalkanen, Aaro J

المساهمون: School of Pharmacy, Activities, School of Medicine / Biomedicine,A.I. Virtanen -instituutti

مصطلحات موضوعية: astrocytes, microglia, neuroinflammation, neuroprotection, prolyl oligopeptidase

وصف الملف: 40-49

العلاقة: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY; http://dx.doi.org/10.1111/bcpt.13094Test; 124; https://erepo.uef.fi/handle/123456789/6859Test

الإتاحة: https://doi.org/10.1111/bcpt.13094Test
https://erepo.uef.fi/handle/123456789/6859Test

المؤلفون: Natunen, Teemu A., Gynther, Mikko, Rostalski, Hannah, Jaako, Külli, Jalkanen, Aaro J.

المساهمون: Academy of Finland, Itä-Suomen Yliopisto, Eesti Teadusagentuur

المصدر: Basic & Clinical Pharmacology & Toxicology ; volume 124, issue 1, page 40-49 ; ISSN 1742-7835 1742-7843

الإتاحة: https://doi.org/10.1111/bcpt.13094Test

المؤلفون: Savolainen, Katja, Ihalainen, Jouni, Jalkanen, Aaro J., Forsberg, Markus M.

المساهمون: Tekes, Suomen Kulttuurirahasto

المصدر: Psychopharmacology ; volume 236, issue 4, page 1245-1253 ; ISSN 0033-3158 1432-2072

مصطلحات موضوعية: Pharmacology

الإتاحة: https://doi.org/10.1007/s00213-018-5130-2Test

المؤلفون: Leikas, Juuso V., Kohtala, Samuel, Theilmann, Wiebke, Jalkanen, Aaro J., Forsberg, Markus M., Rantamäki, Tomi

المساهمون: Suomen Akatemia

المصدر: Journal of Neurochemistry ; volume 142, issue 3, page 456-463 ; ISSN 0022-3042 1471-4159

الإتاحة: https://doi.org/10.1111/jnc.14066Test