-
1
المؤلفون: Timo Heinrich, Carl Peterson, Richard Schneider, Sakshi Garg, Daniel Schwarz, Jakub Gunera, Anita Seshire, Lisa Kötzner, Sarah Schlesiger, Djordje Musil, Heike Schilke, Benjamin Doerfel, Patrizia Diehl, Pia Böpple, Ana R. Lemos, Pedro M. F. Sousa, Filipe Freire, Tiago M. Bandeiras, Emma Carswell, Nicholas Pearson, Sameer Sirohi, Mollie Hooker, Elisabeth Trivier, Rebecca Broome, Alexander Balsiger, Abigail Crowden, Christian Dillon, Dirk Wienke
المصدر: Journal of Medicinal Chemistry. 65:9206-9229
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e22c0126effbafdbcab44017975b2c5dTest
https://doi.org/10.1021/acs.jmedchem.2c00403Test -
2
المؤلفون: Timo, Heinrich, Carl, Peterson, Richard, Schneider, Sakshi, Garg, Daniel, Schwarz, Jakub, Gunera, Anita, Seshire, Lisa, Kötzner, Sarah, Schlesiger, Djordje, Musil, Heike, Schilke, Benjamin, Doerfel, Patrizia, Diehl, Pia, Böpple, Ana R, Lemos, Pedro M F, Sousa, Filipe, Freire, Tiago M, Bandeiras, Emma, Carswell, Nicholas, Pearson, Sameer, Sirohi, Mollie, Hooker, Elisabeth, Trivier, Rebecca, Broome, Alexander, Balsiger, Abigail, Crowden, Christian, Dillon, Dirk, Wienke
المصدر: Journal of medicinal chemistry. 65(13)
مصطلحات موضوعية: Mice, Neoplasms, Animals, TEA Domain Transcription Factors, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::8f113375d5ab1fa46e3e2aecd3136fe8Test
https://pubmed.ncbi.nlm.nih.gov/35763499Test -
3
المؤلفون: Jeyaprakashnarayanan Seenisamy, Frank Becker, Djordje Musil, Jörg Bomke, Jakub Gunera, Uwe Eckert, Timo Heinrich, Felix Rohdich, Kerrin Hansen, Beatrix Blume, Christian Siegl, Frank Zenke, Jens Pfalzgraf, Dieter Spuck, Ansgar Wegener, Birgitta Leuthner, Melanie Dietz, Manja Friese-Hamim
المصدر: Journal of Medicinal Chemistry. 62:11119-11134
مصطلحات موضوعية: A549 cell, 0303 health sciences, Chemistry, Cell growth, Pharmacology, 01 natural sciences, METAP2, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Molecular Medicine, Structure–activity relationship, Target protein, Efflux, Lead compound, 030304 developmental biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::539fb7d602f3d1bbfe1d4a86e7331eb7Test
https://doi.org/10.1021/acs.jmedchem.9b01070Test -
4
المؤلفون: Peter Kolb, Jakub Gunera, Daniel M. Rosenbaum, Jillian G. Baker, Niek van Hilten
المصدر: Journal of medicinal chemistry. 63(19)
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Plasma protein binding, CHO Cells, Ligands, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Cricetulus, Orexin Receptors, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Receptor, 030304 developmental biology, 0303 health sciences, biology, Molecular Structure, Chemistry, Chinese hamster ovary cell, biology.organism_classification, Orexin receptor, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Docking (molecular), Area Under Curve, Drug Design, Molecular Medicine, Orexin Receptor Antagonists, Protein Binding
وصف الملف:
PDF الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5065d3a1af9918cc2909bd2b48c8ed6cTest
https://pubmed.ncbi.nlm.nih.gov/32977721Test -
5
المؤلفون: Dorothee Weikert, Peter Kolb, Peter Gmeiner, Harald Hübner, Christopher J. Langmead, Frank Kraus, Jakub Gunera, Daniel M. Rosenbaum, Jie Yin, Theresa Pröll, Jan Hellmann, Matthäus Drabek
المصدر: Proc Natl Acad Sci U S A
مصطلحات موضوعية: medicine.drug_class, Protein Conformation, Molecular Dynamics Simulation, Ligands, Receptors, G-Protein-Coupled, Structure-Activity Relationship, Orexin Receptors, medicine, Binding site, Receptor, G protein-coupled receptor, Multidisciplinary, Binding Sites, Crystallography, Chemistry, Suvorexant, Antagonist, Biological Sciences, Receptor antagonist, Orexin receptor, Orexin, Molecular Docking Simulation, Kinetics, Drug Design, Biophysics, Orexin Receptor Antagonists, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1836323ed93ff337a8da4d68cb8d067dTest
https://pubmed.ncbi.nlm.nih.gov/32669442Test -
6
المؤلفون: Timo, Heinrich, Jeyaprakashnarayanan, Seenisamy, Frank, Becker, Beatrix, Blume, Jörg, Bomke, Melanie, Dietz, Uwe, Eckert, Manja, Friese-Hamim, Jakub, Gunera, Kerrin, Hansen, Birgitta, Leuthner, Djordje, Musil, Jens, Pfalzgraf, Felix, Rohdich, Christian, Siegl, Dieter, Spuck, Ansgar, Wegener, Frank T, Zenke
المصدر: Journal of medicinal chemistry. 62(24)
مصطلحات موضوعية: Models, Molecular, Indoles, Endothelial Cells, Mice, Nude, Antineoplastic Agents, Apoptosis, Glioma, Xenograft Model Antitumor Assays, Mice, Structure-Activity Relationship, A549 Cells, Tumor Cells, Cultured, Animals, Humans, Methionyl Aminopeptidases, Female, Caco-2 Cells, Enzyme Inhibitors, Cell Proliferation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::2b4dcbfeb991a35c29e879c5251cd665Test
https://pubmed.ncbi.nlm.nih.gov/31725285Test -
7
المؤلفون: Jillian G. Baker, Jakub Gunera, Denis Schmidt, Peter Kolb
المصدر: ACS Medicinal Chemistry Letters. 8:481-485
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Ligand, Organic Chemistry, Biology, Biochemistry, β2 adrenergic receptor, 03 medical and health sciences, 030104 developmental biology, Docking (molecular), Drug Discovery, Molecule, Substructure, Receptor, G protein-coupled receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ffd39dd1db5605bfcb05ec93c0b092eeTest
https://doi.org/10.1021/acsmedchemlett.6b00363Test -
8
المؤلفون: Shu-Ming Li, Peter Kolb, Florian Kindinger, Jakub Gunera
المصدر: Journal of Biological Chemistry. 292:4003-4021
مصطلحات موضوعية: 0301 basic medicine, Indoles, Prenyltransferase, Protein Prenylation, Crystallography, X-Ray, computer.software_genre, 01 natural sciences, Biochemistry, Substrate Specificity, 03 medical and health sciences, Prenylation, Databases, Protein, Molecular Biology, Indole test, Alkyl and Aryl Transferases, Database, 010405 organic chemistry, Chemistry, Computational Biology, Substrate (chemistry), Cell Biology, Small molecule, 0104 chemical sciences, 030104 developmental biology, Biocatalysis, Cheminformatics, Protein prenylation, computer, Algorithms
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7c4fa750c7acd27ae558643806fc06Test
https://doi.org/10.1074/jbc.m116.759118Test -
9
المؤلفون: Mike Liebhold, Shu-Ming Li, Peter Kolb, Jakub Gunera, Julia Winkelblech, Xiulan Xie
المصدر: Advanced Synthesis & Catalysis. 357:975-986
مصطلحات موضوعية: Indole test, chemistry.chemical_classification, Enzyme, chemistry, Stereochemistry, Prenyltransferase, Tryptophan, Regioselectivity, Organic chemistry, General Chemistry, Ring (chemistry), Friedel–Crafts reaction, Enzyme catalysis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b6920fe9d86c7b17685adbad76e6cc39Test
https://doi.org/10.1002/adsc.201400958Test -
10
المؤلفون: Denis, Schmidt, Jakub, Gunera, Jillian G, Baker, Peter, Kolb
المصدر: ACS medicinal chemistry letters. 8(5)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::98f588f28c82e66cedb799a4704c6f2aTest
https://pubmed.ncbi.nlm.nih.gov/28523097Test