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المؤلفون: Zeliha Yalçin, Daniëlle Koot, Karel Bezstarosti, Daniel Salas-Lloret, Onno B. Bleijerveld, Vera Boersma, Mattia Falcone, Román González-Prieto, Maarten Altelaar, Jeroen A.A. Demmers, Jacqueline J.L. Jacobs
المصدر: Molecular & Cellular Proteomics. 22:100548
مصطلحات موضوعية: Molecular Biology, Biochemistry, Analytical Chemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::346623f55afe523110eed7351629a073Test
https://doi.org/10.1016/j.mcpro.2023.100548Test -
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المؤلفون: Jacqueline J.L. Jacobs, Vera Boersma, Inge de Krijger
المصدر: Trends Cell Biol
مصطلحات موضوعية: 0303 health sciences, DNA Repair, Genome integrity, Cell Cycle Proteins, DNA, Cell Biology, HORMA domain, Computational biology, Mitotic progression, Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Genome maintenance, Mad2 Proteins, Humans, DNA Breaks, Double-Stranded, 030217 neurology & neurosurgery, 030304 developmental biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01242bbd81f34183864f285185a50c56Test
https://doi.org/10.1016/j.tcb.2021.04.002Test -
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المؤلفون: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu
المساهمون: Dev, Harveer [0000-0003-2874-6894], Yang, Fengtang [0000-0002-3573-2354], Balmus, Gabriel [0000-0003-2872-4468], Serra, Violeta [0000-0001-6620-1065], Beli, Petra [0000-0001-9507-9820], Pellegrini, Luca [0000-0002-9300-497X], Deriano, Ludovic [0000-0002-9673-9525], Jacobs, Jacqueline JL [0000-0002-7704-4795], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge [UK] (CAM), Department of Biochemistry [Cambridge], Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris] (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute [Cambridge, Royaume-Uni] (CRUK), Institute of Molecular Biology (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute [Hinxton, UK], AstraZeneca US [Waltham, USA], AstraZeneca [Cambridge, UK], The Wellcome Trust Sanger Institute [Cambridge], Vall d'Hebron Institute of Oncology [Barcelone] (VHIO), Vall d'Hebron University Hospital [Barcelona], The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance, Institut Pasteur [Paris], Johannes Gutenberg - Universität Mainz (JGU)
المصدر: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩مصطلحات موضوعية: MESH: DNA Breaks, Double-Stranded, RAD51, Cell Cycle Proteins, Poly (ADP-Ribose) Polymerase Inhibitor, MESH: Recombinational DNA Repair, Mice, MESH: Animals, DNA Breaks, Double-Stranded, skin and connective tissue diseases, Cancer, Telomere-binding protein, Ovarian Neoplasms, MESH: Breast Neoplasms / metabolism, MESH: Telomere-Binding Proteins / metabolism, 3. Good health, Cell biology, MESH: HEK293 Cells, MESH: Proteins / genetics, MESH: Telomere-Binding Proteins / genetics, MESH: Tumor Suppressor p53-Binding Protein 1 / metabolism, MESH: Xenograft Model Antitumor Assays, Telomere-Binding Proteins, MESH: Ovarian Neoplasms / drug therapy, Bone Neoplasms, MESH: Ovarian Neoplasms / metabolism, Article, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Bone Neoplasms / metabolism, Humans, MESH: Osteosarcoma / metabolism, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Tumor Suppressor p53-Binding Protein 1 / genetics, Dose-Response Relationship, Drug, HEK 293 cells, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, MESH: BRCA1 Protein / deficiency, 030104 developmental biology, Multiprotein Complexes, MESH: Mad2 Proteins / metabolism, MESH: Breast Neoplasms / genetics, MESH: Bone Neoplasms / drug therapy, Cisplatin, Homologous recombination, MESH: Osteosarcoma / genetics, MESH: Female, 0301 basic medicine, DNA End-Joining Repair, MESH: Proteins / metabolism, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, MESH: Osteosarcoma / pathology, MESH: Breast Neoplasms / pathology, Homologous Recombination, Polymerase, MESH: Breast Neoplasms / drug therapy, Osteosarcoma, biology, Chemistry, BRCA1 Protein, DNA damage and repair, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Bone Neoplasms / genetics, DNA-Binding Proteins, MESH: Bone Neoplasms / pathology, Mad2 Proteins, Female, MESH: Ovarian Neoplasms / genetics, Tumor Suppressor p53-Binding Protein 1, MESH: Cisplatin / pharmacology, MESH: Cell Line, Tumor, Lymphocytes, Null, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: BRCA1 Protein / genetics, Poly(ADP-ribose) Polymerase Inhibitors, Cell Line, Tumor, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Mad2 Proteins / genetics, MESH: Ovarian Neoplasms / pathology, Animals, MESH: Mice, MESH: Osteosarcoma / drug therapy, Oligonucleotide, Protective Devices, Recombinational DNA Repair, Cell Biology, MESH: Multiprotein Complexes, Xenograft Model Antitumor Assays, HEK293 Cells, Drug Resistance, Neoplasm, biology.protein, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c03882fb1aad0056e71d15c34e8ed4Test
https://www.repository.cam.ac.uk/handle/1810/282947Test -
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المؤلفون: Stefano Annunziato, Jinhyuk Bhin, Marieke van de Ven, Rachel Brough, Bastiaan Evers, Marco Barazas, Catrin Lutz, Stephen J. Pettitt, Dik C. van Gent, Jacqueline J.L. Jacobs, Stefan J. Roobol, Jessica Frankum, Jos Jonkers, Inge de Krijger, Hind Ghezraoui, Fei Fei Song, Christopher J. Lord, J. Ross Chapman, Ewa Gogola, Sven Rottenberg
المساهمون: Molecular Genetics, Radiology & Nuclear Medicine
المصدر: Barazas, Marco; Annunziato, Stefano; Pettitt, Stephen J; de Krijger, Inge; Ghezraoui, Hind; Roobol, Stefan J; Lutz, Catrin; Frankum, Jessica; Song, Fei Fei; Brough, Rachel; Evers, Bastiaan; Gogola, Ewa; Bhin, Jinhyuk; van de Ven, Marieke; van Gent, Dik C; Jacobs, Jacqueline J L; Chapman, Ross; Lord, Christopher J; Jonkers, Jos and Rottenberg, Sven (2018). The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells. Cell reports, 23(7), pp. 2107-2118. Cell Press 10.1016/j.celrep.2018.04.046 <http://dx.doi.org/10.1016/j.celrep.2018.04.046Test>
Cell Reports
Cell Reports, 23(7), 2107-2118. Cell Pressمصطلحات موضوعية: 0301 basic medicine, DNA end resection, Poly ADP ribose polymerase, 610 Medicine & health, Synthetic lethality, CST complex, Poly(ADP-ribose) Polymerase Inhibitors, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, breast cancer, Cell Line, Tumor, Animals, DNA Breaks, Double-Stranded, Polymerase, drug resistance, biology, 630 Agriculture, Chemistry, TEN1, BRCA1 Protein, Mouse Embryonic Stem Cells, Telomere, BRCA1, genetically engineered mouse model, 3. Good health, Cell biology, Disease Models, Animal, 030104 developmental biology, PARP inhibitor, STN1, Drug Resistance, Neoplasm, Multiprotein Complexes, biology.protein, 570 Life sciences, CTC1, Female, CRISPR-Cas Systems, Homologous recombination, DNA
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9e45d97761e8fba307be9acea689a3Test
http://ora.ox.ac.uk/objects/uuidTest: -
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المؤلفون: Vera Boersma, Jacqueline J.L. Jacobs, Daniel Durocher, Alexandre Orthwein, Jaco van der Torre, Marieke H. Peuscher, Sandra Segura-Bayona, Nathalie Moatti, Brigitte A. Wevers
المصدر: Nature
مصطلحات موضوعية: DNA End-Joining Repair, Telomere-binding protein, Genome instability, Multidisciplinary, DNA repair, DNA replication, REV1, Biology, Molecular biology, Article, Nucleotide excision repair, Cell biology, Telomere
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e5caffebb3dffe6c09d1e44ccb2bbdTest
https://doi.org/10.1038/nature14216Test -
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المؤلفون: Jacqueline J.L. Jacobs, Zeliha Yalçin, Carolin Selenz
المصدر: Frontiers in Genetics, Vol 8 (2017)
Frontiers in Geneticsمصطلحات موضوعية: 0301 basic medicine, Genome instability, Telomerase, Cell division, lcsh:QH426-470, DNA repair, DNA damage, Review, Biology, telomerase, 03 medical and health sciences, ubiquitin, Genetics, telomere maintenance, Genetics (clinical), Telomere-binding protein, Shelterin, Telomere, Cell biology, lcsh:Genetics, 030104 developmental biology, telomere dysfunction, SUMO, Molecular Medicine, shelterin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0356ced88b17b21056ddf1f9bc710cTest
http://journal.frontiersin.org/article/10.3389/fgene.2017.00067/fullTest -
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المؤلفون: Martijn S. Luijsterburg, Wouter W. Wiegant, Alex Pines, Rashmi G. Shah, Anton J.L. de Groot, Inge de Krijger, Alfred C.O. Vertegaal, Girish M. Shah, Haico van Attikum, Jacqueline J.L. Jacobs, Godelieve Smeenk
المصدر: Molecular Cell, 61(4), 547-562
Molecular Cellمصطلحات موضوعية: 0301 basic medicine, DNA End-Joining Repair, DNA repair, Poly (ADP-Ribose) Polymerase-1, Solenoid (DNA), Biology, Chromatin remodeling, Article, Genomic Instability, Histones, 03 medical and health sciences, Cell Line, Tumor, Histone H2A, Histone code, Humans, DNA Breaks, Double-Stranded, Molecular Biology, fungi, Cell Biology, Chromatin Assembly and Disassembly, Molecular biology, Chromatin, 3. Good health, Cell biology, DNA-Binding Proteins, enzymes and coenzymes (carbohydrates), 030104 developmental biology, Histone, HEK293 Cells, biology.protein, Poly(ADP-ribose) Polymerases
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d25b585a2bb9a5c3c0c62172b76acc8Test
http://hdl.handle.net/1887/111886Test -
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المؤلفون: Jacqueline J.L. Jacobs, Marieke H. Peuscher
المصدر: Cell Cycle. 11:1524-1534
مصطلحات موضوعية: Senescence, Genome instability, Genetics, Telomere-binding protein, DNA Repair, DNA repair, Ubiquitination, Sumoylation, Cell Biology, Telomere, Biology, Chromatin, Genomic Instability, chemistry.chemical_compound, chemistry, Humans, Protein Processing, Post-Translational, Molecular Biology, DNA, Uncapping, DNA Damage, Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9146c2eef86d86821253c68c05d988dfTest
https://doi.org/10.4161/cc.19847Test -
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المؤلفون: Jacqueline J.L. Jacobs
المصدر: Nucleus. 3:143-149
مصطلحات موضوعية: Genetics, Genome instability, Mutation, Genome, DNA repair, DNA damage, Ubiquitin-Protein Ligases, Extra View, Chromosome, Cell Biology, Telomere, Biology, medicine.disease_cause, chemistry.chemical_compound, chemistry, Chromosomal Instability, Chromosome instability, medicine, Animals, Humans, DNA, DNA Damage
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b705d3ee23dc9592a7b90e56ef9985Test
https://doi.org/10.4161/nucl.19322Test -
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المؤلفون: Maarten van Lohuizen, Jacqueline J.L. Jacobs, Sophia W.M. Bruggeman, Yvan Arsenijevic, Petra van der Stoop, Ellen Tanger, Danielle Hulsman, Silvia Marino, Merel E. Valk-Lingbeek, Karin Kieboom, Carly Leung
المصدر: Genes & Development. 19:1438-1443
مصطلحات موضوعية: Heterozygote, Lymphoid Tissue, Cellular differentiation, macromolecular substances, Biology, Research Communications, Mice, Cerebellum, Proto-Oncogene Proteins, Tumor Suppressor Protein p14ARF, Genetics, Animals, RNA, Messenger, Progenitor cell, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Mice, Knockout, Neurons, Polycomb Repressive Complex 1, Cell growth, Genes, p16, Multipotent Stem Cells, Nuclear Proteins, Cell Differentiation, Neural stem cell, body regions, Mice, Inbred C57BL, Repressor Proteins, BMI1, Multipotent Stem Cell, Cancer research, Stem cell, Cell aging, Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62514df7f026dd4462d7ae75e06c786Test
https://doi.org/10.1101/gad.1299305Test