التفاصيل البيبلوغرافية
| العنوان: |
Differentiation of burn wounds in an in vivo porcine model using terahertz spectroscopy |
| المؤلفون: |
Osman, Omar B., Jack Tan, Timothy, Henry, Sam, Warsen, Adelaide, Farr, Navid, McClintic, Abbi M., Wang, Yak-Nam, Arbabi, Saman, Arbab, M. Hassan |
| المصدر: |
Biomedical Optics Express; November 2020, Vol. 11 Issue: 11 p6528-6535, 8p |
| مستخلص: |
The accuracy of current burn triage techniques has remained between 50-70%. Accordingly, there is a significant clinical need for the quantitative and accurate assessment of partial-thickness burn injuries. Porcine skin represents the closest animal model to human skin, and is often used in surgical skin grafting procedures. In this study, we used a standardized in vivo porcine burn model to obtain terahertz (THz) point-spectroscopy measurements from burns with various severities. We then extracted two reflection hyperspectral parameters, namely spectral area under the curve between approximately 0.1 and 0.9 THz (−10 dB bandwidth in each spectrum), and spectral slope, to characterize each burn. Using a linear combination of these two parameters, we accurately classified deep partial- and superficial partial-thickness burns (p = 0.0159), compared to vimentin immunohistochemistry as the gold standard for burn depth determination. |
| قاعدة البيانات: |
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