دورية أكاديمية
Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer
| العنوان: | Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer |
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| المؤلفون: | Juliana Prado Gusson-Zanetoni, Luana Pereira Cardoso, Stefanie Oliveira de Sousa, Laura Luciana de Melo Moreira Silva, Júlia de Oliveira Martinho, Tiago Henrique, Eloiza Helena Tajara, Sonia Maria Oliani, Flávia Cristina Rodrigues-Lisoni |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 11, p 5762 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | inflammation, herbal medicine, PTGS2, MAPK, MMPs, cytokines, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of cancer development. The aim of this study was to investigate the molecular mechanisms of action of piperine in relation to its potential anticancer effect on head and neck cancer cells. Parameters related to neoplastic potential and cytokine, protein and gene expression were investigated in head and neck cancer cell lines (HEp-2 and SCC-25) treated with piperine. The results of the tests indicated that piperine modified morphology and inhibited viability and the formation of cell colonies. Piperine promoted genotoxicity by triggering apoptosis and cell cycle arrest in the G2/M and S phases. A decrease in cell migration was also observed, and there was decreased expression of MMP2/9 genes. Piperine also reduced the expression of inflammatory molecules (PTGS2 and PTGER4), regulated the secretion of cytokines (IFN-γ and IL-8) and modulated the expression of ERK and p38. These results suggest that piperine exerts anticancer effects on tumor cells by regulating signaling pathways associated with head and neck cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/25/11/5762Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms25115762 |
| الوصول الحر: | https://doaj.org/article/156351bd470b4a6d9a5d7908e1956906Test |
| رقم الانضمام: | edsdoj.156351bd470b4a6d9a5d7908e1956906 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25115762 |