دورية أكاديمية
Serum KL-6 and the mortality of patients with connective tissue disease-associated interstitial lung disease: A meta-analysis
| العنوان: | Serum KL-6 and the mortality of patients with connective tissue disease-associated interstitial lung disease: A meta-analysis |
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| المؤلفون: | Mei Hong, Xue Yin, Wenmei Yan, Wei Guo, Hongmei Liu, Haisheng Yang |
| المصدر: | Biomolecules & Biomedicine (2024) |
| بيانات النشر: | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Interstitial lung disease (ILD), connective tissue disease (CTD), Krebs von den Lungen-6 (KL-6), mortality, meta-analysis, Biology (General), QH301-705.5 |
| الوصف: | Connective tissue disease-associated interstitial lung disease (CTD-ILD) is an important underlying cause of morbidity and mortality in patients with CTD. Serum Krebs von den Lungen-6 (KL-6) is an immune factor which has been related to the severity of ILD. This systematic review and meta-analysis aimed to evaluate the association between serum KL-6 and mortality of patients with CTD-ILD. Longitudinal studies relevant to the aim of the meta-analysis were retrieved by search of electronic databases including PubMed, Web of Science, and Embase. A random-effects model was used to combine the data by incorporating the influence of between-study heterogeneity. Fifteen cohorts involving 1737 patients with CTD-ILD were included. During a mean follow-up of 35.3 months, 430 (24.8%) patients died. Compared to those with a lower KL-6 at admission, patients with a higher KL-6 were associated with a higher mortality risk during follow-up (risk ratio: 2.18, 95% confidence interval: 1.66 to 2.87, P < 0.001; I2 = 20%). Subgroup analysis showed a significant association in studies from Asian countries, but not in those from non-Asian countries; in studies with cutoff of KL-6 derived in receiver operating characteristic (ROC) curve analysis, but not in those derived from other methods; in studies with multivariate analysis, but not in those with univariate analysis (P for subgroup difference all < 0.05). The association was not significantly affected by different CTDs or methods for measuring serum KL-6. In conclusion, a high serum KL-6 may be a risk factor of increased mortality in patients with CTD-ILD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2831-0896 2831-090X |
| العلاقة: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/10368Test; https://doaj.org/toc/2831-0896Test; https://doaj.org/toc/2831-090XTest |
| DOI: | 10.17305/bb.2024.10368 |
| الوصول الحر: | https://doaj.org/article/4c991e79b7ac47b08d41f7a9f55198d8Test |
| رقم الانضمام: | edsdoj.4c991e79b7ac47b08d41f7a9f55198d8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 28310896 2831090X |
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| DOI: | 10.17305/bb.2024.10368 |