التفاصيل البيبلوغرافية
| العنوان: |
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells. |
| المؤلفون: |
Colli, Maikel Luis, Ramos-Rodríguez, Mireia, Nakayasu, Ernesto Satoshi, Alvelos, Maria Inês, Lopes, Miguel, Hill, Jessica L E, Turatsinze, Jean Valéry, Coomans De Brachene, Alexandra, Russell, Mark M.A., Raurell-Vila, Helena, Castela, Angela, Juan-Mateu, Jonàs, Webb-Robertson, Bobbie-Jo M., Krogvold, Lars, Dahl-Jorgensen, Knut, Marselli, L, Marchetti, P., Richardson, Sarah J, Morgan, Noel G, Metz, Thomas O., Pasquali, Lorenzo, Eizirik, Decio L. |
| المصدر: |
Nature communications, 11 (1 |
| سنة النشر: |
2020 |
| المجموعة: |
DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: |
Sciences bio-médicales et agricoles, Alternative Splicing -- drug effects, Cells, Cultured, Chromatin -- drug effects -- metabolism, Data Mining, Diabetes Mellitus, Type 1 -- genetics, Gene Expression Regulation -- drug effects, Gene Regulatory Networks, Humans, Insulin-Secreting Cells -- drug effects -- physiology, Interferon-alpha -- metabolism -- pharmacology, Protein Interaction Maps, Proteomics, Transcription Factors -- genetics -- metabolism, Transcription Initiation Site |
| الوصف: |
Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We presently characterize human beta cell responses to IFNα by combining ATAC-seq, RNA-seq and proteomics assays. The initial response to IFNα is characterized by chromatin remodeling, followed by changes in transcriptional and translational regulation. IFNα induces changes in alternative splicing (AS) and first exon usage, increasing the diversity of transcripts expressed by the beta cells. This, combined with changes observed on protein modification/degradation, ER stress and MHC class I, may expand antigens presented by beta cells to the immune system. Beta cells also up-regulate the checkpoint proteins PDL1 and HLA-E that may exert a protective role against the autoimmune assault. Data mining of the present multi-omics analysis identifies two compound classes that antagonize IFNα effects on human beta cells. ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
1 full-text file(s): application/pdf |
| اللغة: |
English |
| العلاقة: |
uri/info:doi/10.1038/s41467-020-16327-0; uri/info:pii/10.1038/s41467-020-16327-0; uri/info:pmid/32444635; uri/info:scp/85085264347; uri/info:pmcid/PMC7244579; https://dipot.ulb.ac.be/dspace/bitstream/2013/341152/1/doi_324796.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/341152Test |
| الإتاحة: |
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/341152Test |
| رقم الانضمام: |
edsbas.C2BA466F |
| قاعدة البيانات: |
BASE |
