دورية أكاديمية
Oxidative Stress, Mutations and Chromosomal Aberrations Induced by In Vitro and In Vivo Exposure to Furan
| العنوان: | Oxidative Stress, Mutations and Chromosomal Aberrations Induced by In Vitro and In Vivo Exposure to Furan |
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| المؤلفون: | Russo M. T., De Luca G., Palma N., Leopardi P., Degan P., Cinelli S., Pepe G., Mosesso P., Di Carlo E., Sorrentino C., Musiani P., Crebelli R., Bignami M., Dogliotti E. |
| المساهمون: | Russo, M. T., De Luca, G., Palma, N., Leopardi, P., Degan, P., Cinelli, S., Pepe, G., Mosesso, P., Di Carlo, E., Sorrentino, C., Musiani, P., Crebelli, R., Bignami, M., Dogliotti, E. |
| سنة النشر: | 2021 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | Clastogenicity, Furan, Inter-strand cross-link, Mutagenicity, Oxidative DNA base damage, Animal, Carcinogen, Cell Line, Chromosome Aberration, DNA Damage, Dose-Response Relationship, Drug, Human, Liver, Mice, Micronuclei, Chromosome-Defective, Mutagen, Mutation, Oxidation-Reduction, Oxidative Stress |
| الوصف: | Furan is a volatile compound that is formed in foods during thermal processing. It is classified as a possible human carcinogen by international authorities based on sufficient evidence of carcinogenicity from studies in experimental animals. Although a vast number of studies both in vitro and in vivo have been performed to investigate furan genotoxicity, the results are inconsistent, and its carcinogenic mode of action remains to be clarified. Here, we address the mutagenic and clastogenic activity of furan and its prime reactive metabolite cis-2 butene-1,4-dial (BDA) in mammalian cells in culture and in mouse animal models in a search for DNA lesions responsible of these effects. To this aim, Fanconi anemia-derived human cell lines defective in the repair of DNA inter-strand crosslinks (ICLs) and Ogg1−/− mice defective in the removal of 8-hydroxyguanine from DNA, were used. We show that both furan and BDA present a weak (if any) mutagenic activity but are clear inducers of clastogenic damage. ICLs are strongly indicated as key lesions for chromosomal damage whereas oxidized base lesions are unlikely to play a critical role. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34575853; info:eu-repo/semantics/altIdentifier/wos/WOS:000700780400001; volume:22; issue:18; firstpage:9687; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11564/763948Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85114319125; https://www.mdpi.com/1422-0067/22/18/9687Test |
| DOI: | 10.3390/ijms22189687 |
| الإتاحة: | https://doi.org/10.3390/ijms22189687Test http://hdl.handle.net/11564/763948Test https://www.mdpi.com/1422-0067/22/18/9687Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BED27810 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms22189687 |
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