Randomized GH trial with two different dosages in combination with a GnRH analogue in short small for gestational age children: effects on metabolic profile and serum GH, IGF1, and IGFBP3 levels
| العنوان: | Randomized GH trial with two different dosages in combination with a GnRH analogue in short small for gestational age children: effects on metabolic profile and serum GH, IGF1, and IGFBP3 levels |
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| المؤلفون: | Inge Rowaan, Jaap Mulder, Merel Willeboer, Danielle C. M. van der Kaay, Maria A. J. de Ridder, Flip J. P. C. M. van der Hulst, Denise van Elswijk, Dick Mul, Boudewijn Bakker, Anita C. S. Hokken-Koelega, E J Schroor |
| المساهمون: | Pediatrics, Neurology, Department of Psychology, Education and Child Studies |
| المصدر: | European Journal of Endocrinology, 162(5), 887-895. Bioscientifica Ltd |
| بيانات النشر: | Bioscientifica Ltd, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Dose, Adolescent, Endocrinology, Diabetes and Metabolism, IGFBP3, Blood Pressure, law.invention, Endocrinology, Insulin resistance, Randomized controlled trial, law, Internal medicine, medicine, Humans, Insulin-Like Growth Factor I, Child, Growth Disorders, medicine.diagnostic_test, business.industry, Human Growth Hormone, Infant, Newborn, General Medicine, medicine.disease, Insulin-Like Growth Factor Binding Proteins, Blood pressure, Insulin-Like Growth Factor Binding Protein 3, Adipose Tissue, Infant, Small for Gestational Age, Lean body mass, Body Composition, Small for gestational age, Female, Insulin Resistance, Leuprolide, Lipid profile, business |
| الوصف: | BackgroundGnRH analogue (GnRHa) combined with GH treatment has been proposed to increase adult height. Effect on metabolic profile and GH, IGF1, and IGFBP3 levels in short small for gestational age (SGA) children is unknown.ObjectiveTo assess fat mass and lean body mass SDS, percentage trunk fat, blood pressure (BP), insulin sensitivity (Si), β-cell function (disposition index, DI), lipid profile, and GH, IGF1, and IGFBP3 levels during 2 years of combined treatment.SubjectsForty-one pubertal short SGA children with a mean (±s.d.) age of 12.1 (±1.0) years.DesignChildren received 3.75 mg of leuprolide acetate depot subcutaneously every 4 weeks, and they were randomly assigned to receive 1 mg (group A) or 2 mg (group B) of GH/m2per day.ResultsPercentage trunk fat increased in both groups, but to a lower extent in group B. Lean body mass SDS increased only in group B. Changes in BP, Si, DI, and lipids were similar in both groups. Si significantly decreased, but DI remained unchanged. Lipids remained normal. GH and IGF1 levels were significantly higher in group B.ConclusionOur study is the first to report that 2 years of combined treatment with a GnRHa and either 1 or 2 mg GH/m2per day does not adversely affect body composition and metabolic profile of short SGA children who come under medical attention at the onset of puberty. There was a dose-dependent effect on fat mass SDSheight, percentage trunk fat, lean body mass SDSheight, and GH and IGF1 levels in favor of treatment with GnRHa and the higher GH dose of 2 mg/m2per day. |
| تدمد: | 1479-683X 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeba17850b9c94ef8761b041653b6d6Test https://doi.org/10.1530/EJE-09-1113Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4aeba17850b9c94ef8761b041653b6d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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