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المؤلفون: Walker, RG, Thomson, G, Malone, K, Nowicki, MW, Brown, E, Blake, DG, Turner, NJ, Walkinshaw, MD, Grant, KM, Mottram, JC, Kita, K
المساهمون: Kita, K
المصدر: PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1033 (2011)
PLoS Neglected Tropical Diseases
Walker, R G, Thomson, G, Malone, K, Nowicki, M W, Brown, E, Blake, D G, Turner, N J, Walkinshaw, M D, Grant, K M & Mottram, J C 2011, ' High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase ', PLoS Neglected Tropical Diseases, vol. 5, no. 4, e1033, pp.-. https://doi.org/10.1371/journal.pntd.0001033Testمصطلحات موضوعية: Protein kinase complex, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Antiprotozoal Agents, Drug Evaluation, Preclinical, Chemical library, Pharmacology, Toxicology and Pharmaceutics(all), Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Parasitic Sensitivity Tests, Cyclin-dependent kinase, Animals, Humans, Leishmania major, Amastigote, Protein Kinase Inhibitors, 030304 developmental biology, Mice, Inbred BALB C, 0303 health sciences, Cyclin-dependent kinase 1, Infectious Diseases/Antimicrobials and Drug Resistance, biology, lcsh:Public aspects of medicine, Cyclin-dependent kinase 2, Infectious Diseases/Protozoal Infections, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, biology.organism_classification, Small molecule, Cyclin-Dependent Kinases, High-Throughput Screening Assays, 3. Good health, Cell biology, Infectious Diseases, Infectious Diseases/Neglected Tropical Diseases, Biochemistry, chemistry, Biochemistry/Small Molecule Chemistry, 030220 oncology & carcinogenesis, biology.protein, Research Article, Pharmacology/Drug Development
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https://ora.ox.ac.uk/objects/uuid:b7ac0f17-98da-41fb-a2d5-8f53ae85b653Test -
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المؤلفون: Makie Taal, David J. Conway, Climent Casals-Pascual, Davis Nwakanma, Aja Adam Jagne Sonko, Kalifa Bojang, Serign J. Ceesay, Sarah I. Nogaro, Natalia Gomez-Escobar, Tumani Corrah, Ebako N. Takem, Michael Walther, Momodou Cherno Jaye, Anthony J. C. Fulford
المصدر: PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12242 (2010)مصطلحات موضوعية: Male, Veterinary medicine, Time Factors, Endemic Diseases, Psychological intervention, lcsh:Medicine, Public Health and Epidemiology/Infectious Diseases, 0302 clinical medicine, Epidemiology, 030212 general & internal medicine, Socioeconomics, lcsh:Science, Child, Malarial parasites, Multidisciplinary, Data Collection, 1. No poverty, Public Health and Epidemiology/Global Health, Disease control, 3. Good health, Child, Preschool, Female, Gambia, Seasons, Research Article, Infectious Diseases/Tropical and Travel-Associated Diseases, Adult, Infectious Diseases/Epidemiology and Control of Infectious Diseases, medicine.medical_specialty, Adolescent, 030231 tropical medicine, Disease distribution, 03 medical and health sciences, Young Adult, parasitic diseases, medicine, Humans, business.industry, lcsh:R, Infectious Diseases/Protozoal Infections, Infant, medicine.disease, Malaria, lcsh:Q, Public Health and Epidemiology/Epidemiology, Rural area, Endemic diseases, business, Laboratories
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https://ora.ox.ac.uk/objects/uuid:4ed14527-6bbb-4f21-878e-4f93542cd4baTest -
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المؤلفون: Bui H. Manh, Rosalind E. Howes, Andrew J. Tatem, Thomas P. Van Boeckel, William H. Temperley, Anand P. Patil, J. Kevin Baird, Carlos A Guerra, Peter W. Gething, Robert W. Snow, Simon I. Hay, Iqbal R. F. Elyazar, Caroline W Kabaria
المصدر: PLoS Neglected Tropical Diseases, Vol 4, Iss 8, p e774 (2010)
PLoS neglected tropical diseases, 4 (8
PLoS Neglected Tropical Diseasesمصطلحات موضوعية: medicine.medical_specialty, Asia, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Population, 030231 tropical medicine, Plasmodium vivax, Risk Assessment, Plasmodium, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, parasitic diseases, Epidemiology, Malaria, Vivax, medicine, Humans, education, 030304 developmental biology, 0303 health sciences, education.field_of_study, Geography, Ecologie, biology, lcsh:Public aspects of medicine, Infectious Diseases/Protozoal Infections, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Public Health and Epidemiology/Global Health, biology.organism_classification, medicine.disease, 3. Good health, Infectious Diseases, Transmission (mechanics), Vector (epidemiology), Africa, Americas, Risk assessment, Malaria, Research Article, Demography
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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f334da912b88c33135b8393a572b5c1fTest
https://doi.org/10.1371/journal.pntd.0000774Test -
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المؤلفون: Dominic P. Kwiatkowski, Conor P. Doherty, Sarah H. Atkinson, Chidi V. Nweneka, Sharon E. Cox, Hala Ghattas, Kirk A. Rockett, Anthony J. C. Fulford, Andrew M. Prentice
المصدر: PLoS ONE, Vol 2, Iss 4, p e362 (2007)
PLoS ONEمصطلحات موضوعية: 030231 tropical medicine, Public Health and Epidemiology/Infectious Diseases, lcsh:Medicine, Medical sciences, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Tropical medicine, Immunology/Immunity to Infections, Genotype, medicine, Humans, Genetic Predisposition to Disease, Longitudinal Studies, Allele, Promoter Regions, Genetic, lcsh:Science, Genetics and Genomics/Genetics of Disease, 030304 developmental biology, Nutrition, 0303 health sciences, Sickle cell trait, Likelihood Functions, Multidisciplinary, biology, Haptoglobins, Haptoglobin, Haplotype, lcsh:R, Acute-phase protein, Infectious Diseases/Protozoal Infections, medicine.disease, Haemolysis, 3. Good health, Malaria, Haplotypes, Child, Preschool, Immunology, biology.protein, lcsh:Q, Research Article
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المصدر: PloS Pathogens
PLOS Pathogens, Vol. 6, No 10 (2010)
PLoS Pathogens, Vol 6, Iss 10, p e1001132 (2010)
PLoS Pathogensمصطلحات موضوعية: Fetal Proteins, lcsh:Immunologic diseases. Allergy, Gliding motility, Movement, Amino Acid Motifs, Molecular Sequence Data, Immunology, Formins, Motility, macromolecular substances, Biology, Models, Biological, Microbiology, Host-Parasite Interactions, 03 medical and health sciences, Cell Biology/Cytoskeleton, Virology, Genetics, Tissue Distribution, Amino Acid Sequence, Molecular Biology, lcsh:QH301-705.5, Actin, 030304 developmental biology, ddc:616, 0303 health sciences, Microscopy, Video, Microfilament Proteins, 030302 biochemistry & molecular biology, Infectious Diseases/Protozoal Infections, Nuclear Proteins, Actin remodeling, Microfilament Protein, Actins, Protein Structure, Tertiary, Cell biology, Profilin, lcsh:Biology (General), biology.protein, Mutant Proteins, Parasitology, MDia1, Protein Multimerization, Microbiology/Cellular Microbiology and Pathogenesis, lcsh:RC581-607, Toxoplasma, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d61054b1ded49e55a0e41e35871fedeTest
http://www.ncbi.nlm.nih.gov/pubmed/20949068Test -
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المؤلفون: Renato Sathler-Avelar, Juliana A. S. Gomes, Manoel Otávio da Costa Rocha, Fernanda Fortes de Araújo, Rodrigo Correa-Oliveira, Andréa Teixeira-Carvalho, Paulo R. Z. Antas, R.T. Pinho, Danielle Marquete Vitelli-Avelar, Olindo Assis Martins-Filho, Silvana Maria Elói-Santos
المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 5, Iss 5, p e992 (2011)مصطلحات موضوعية: lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Trypanosoma cruzi, Population, Immunology/Immunomodulation, chemical and pharmacologic phenomena, Review, Biology, T-Lymphocytes, Regulatory, Immune tolerance, Immunophenotyping, Immune system, Antigen, Antigens, CD, Immune Tolerance, Cytotoxic T cell, Humans, Chagas Disease, education, education.field_of_study, CD40, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, Infectious Diseases/Protozoal Infections, FOXP3, lcsh:RA1-1270, hemic and immune systems, Infectious Diseases, Immunology, biology.protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c1eed8da7fed5a8d8f217512daf8a9Test
https://pubmed.ncbi.nlm.nih.gov/21655351Test -
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المؤلفون: Daniel L. Hartl, Daria Van Tyne, Elaine Angelino, Kayla G. Barnes, Nicholas A. Furlotte, Bruce W. Birren, David M. B. Rosen, Dyann F. Wirth, Souleymane Mboup, Daniel L. K. Yamins, Ilya Shlyakhter, Charles A. Johnson, Rachel F. Daniels, Sarah K. Volkman, Joseph F. Cortese, Eleazar Eskin, Justin S. Becker, Sharon R. Grossman, Christian T. Happi, Elinor K. Karlsson, Daniel E. Neafsey, Daouda Ndiaye, Pardis C. Sabeti, Ousmane Sarr, Hyun Min Kang, Danny A. Milner, Eric S. Lander, Stephen F. Schaffner, Amanda K. Lukens, Daniel J. Park, Roger C. Wiegand
المساهمون: Moran, Nancy A, Whitaker College of Health Sciences and Technology, Broad Institute of MIT and Harvard, Massachusetts Institute of Technology. Department of Biology, Lander, Eric S., Park, Daniel J., Schaffner, Stephen F., Neafsey, Daniel E., Cortese, Joseph F., Daniels, Rachel F., Johnson, Charles A., Shlyakhter, Ilya, Grossman, Sharon Rachel, Karlsson, Elinor K., Birren, Bruce W., Wiegand, Roger C., Wirth, Dyann F., Volkman, Sarah K., Sabeti, Pardis C.
المصدر: PLoS Genetics, Vol 7, Iss 4, p e1001383 (2011)
PLoS Genetics
PLoS genetics, vol 7, iss 4
PLoSمصطلحات موضوعية: Cancer Research, Linkage disequilibrium, Drug Resistance, Gene Dosage, Gene Expression, Genome-wide association study, Linkage Disequilibrium, chemistry.chemical_compound, 2.2 Factors relating to the physical environment, Copy-number variation, Aetiology, Malaria, Falciparum, Genetics (clinical), Genetics, biology, Mefloquine, Single Nucleotide, Genetics and Genomics/Microbial Evolution and Genomics, Infectious Diseases, Ethanolamines, HIV/AIDS, Genetics and Genomics/Gene Discovery, Infection, medicine.drug, Research Article, Falciparum, Genotype, lcsh:QH426-470, Plasmodium falciparum, Locus (genetics), Polymorphism, Single Nucleotide, Antimalarials, Rare Diseases, Halofantrine, Genetic, Genetics and Genomics/Population Genetics, medicine, Polymorphism, Selection, Genetic, Molecular Biology, Selection, Ecology, Evolution, Behavior and Systematics, Genetic Association Studies, Fluorenes, Lumefantrine, Prevention, Human Genome, Infectious Diseases/Protozoal Infections, Genetic Variation, Phenanthrenes, medicine.disease, biology.organism_classification, Malaria, Vector-Borne Diseases, lcsh:Genetics, Orphan Drug, Good Health and Well Being, chemistry, Haplotypes, Genetic Loci, Antimicrobial Resistance, Developmental Biology
وصف الملف: application/pdf
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http://europepmc.org/articles/PMC3080868?pdf=renderTest -
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المؤلفون: Tatiana M. Lopera-Mesa, Hisashi Fujioka, Nathaniel J. Brittain, Rick M. Fairhurst, Chanaki Amaratunga, Rushina Cholera, Takayuki Arie, Jeffrey R. Keefer
المصدر: PLoS ONE, Vol 6, Iss 4, p e14798 (2011)
PLoS ONEمصطلحات موضوعية: Erythrocytes, Plasmodium falciparum, lcsh:Medicine, Parasitemia, Plasmodium, Immunoglobulin G, Immune system, Immunity, Immunology/Immunity to Infections, hemic and lymphatic diseases, Fetal hemoglobin, parasitic diseases, medicine, Animals, Humans, Malaria, Falciparum, lcsh:Science, Cells, Cultured, Fetal Hemoglobin, Multidisciplinary, biology, lcsh:R, Infant, Newborn, Infectious Diseases/Protozoal Infections, Infant, medicine.disease, biology.organism_classification, Immunology, biology.protein, Female, lcsh:Q, Disease Susceptibility, Hematology/Hemoglobinopathies, Immunity, Maternally-Acquired, Malaria, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e46c76a96ccb9bd100338ecbccb42deTest
http://europepmc.org/articles/PMC3075246?pdf=renderTest -
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المؤلفون: Takeshi Hatta, Yasunobu Matsumoto, M. Abdul Alim, Takeharu Miyoshi, Anisuzzaman, Naotoshi Tsuji, Kayoko Yamaji, M. Khyrul Islam, Kozo Fujisaki
المصدر: PLoS Pathogens, Vol 7, Iss 3, p e1001312 (2011)
PLoS Pathogensمصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, Ixodidae, Plasmin, Immunology, Protozoan Proteins, Tick, Fibrinogen, Microbiology, Fibrin, Host-Parasite Interactions, Plasminogen Activators, Virology, Genetics, medicine, Animals, Microbiology/Parasitology, Fibrinolysin, RNA, Messenger, Salivary Proteins and Peptides, Molecular Biology, lcsh:QH301-705.5, RNA, Double-Stranded, biology, Reverse Transcriptase Polymerase Chain Reaction, Calcium-Binding Proteins, Infectious Diseases/Protozoal Infections, Microbiology/Medical Microbiology, Anticoagulants, Feeding Behavior, biology.organism_classification, Blood, Biochemistry, lcsh:Biology (General), biology.protein, Parasitology, Haemaphysalis longicornis, Microbiology/Cellular Microbiology and Pathogenesis, lcsh:RC581-607, Plasminogen activator, medicine.drug, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8943b8f94d67b049c02e7220af4fc40Test
http://europepmc.org/articles/PMC3053353?pdf=renderTest -
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المؤلفون: Agnès Hovasse, Christine Schaeffer-Reiss, Alain Van Dorsselaer, Thomas Mouveaux, Alejandro Olguin-Lamas, Stanislas Tomavo, Edwige Madec, Christian Slomianny, Elisabeth Werkmeister, Stéphane Delhaye, Isabelle Callebaut
المساهمون: Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de minéralogie et de physique des milieux condensés (IMPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate, Université de Lille, Sciences et Technologies-Institut National de la Santé et de la Recherche Médicale (INSERM), This research was funded by the Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante et de la Recherche Medicale(INSERM), Institut Pasteur de Lille (IPL). The funders had no role in study design, data collection and analysis, decision to publish, or preparationof the manuscript., We would like to thank Dewailly E and Mortuaire M for excellent technical assistance, especially in the earlier phase of this study. We acknowledge Drs Harb O and Roos DS (University of Pennsylvania) for providing the nucleotide sequence of T. gondii rDNA 18S. We are indebted to Drs Hakimi A and Leprince D for providing nucleosome and antibodies specific to core histones, respectively. Special thanks to Drs Gordon Langsley and Robert Walker for critical reading the manuscript and all members of the lab for fruitful discussions., Centre d’Infection et d’Immunité de Lille (CIIL) - U1019 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Thomas, Danielle
المصدر: PLoS Pathogens
PLoS Pathogens, Vol 7, Iss 3, p e1001328 (2011)
PLoS Pathogens, Public Library of Science, 2011, 7 (3), pp.e1001328. ⟨10.1371/journal.ppat.1001328⟩
PLoS Pathogens, 2011, 7 (3), pp.e1001328. ⟨10.1371/journal.ppat.1001328⟩مصطلحات موضوعية: Proteomics, MESH: Sequence Analysis, Protein, Protozoan Proteins, Antibodies, Protozoan, MESH: Toxoplasma/pathogenicity, MESH: DNA-Binding Proteins/chemistry, Regulatory Sequences, Nucleic Acid, Mass Spectrometry, MESH: Protozoan Proteins/chemistry, Histones, MESH: Cell Nucleolus/metabolism, Sequence Analysis, Protein, MESH: Reverse Transcriptase Polymerase Chain Reaction, Transcriptional regulation, MESH: Gene Silencing, Nuclear protein, MESH: Ribosomes/metabolism, Promoter Regions, Genetic, MESH: High-Throughput Nucleotide Sequencing, lcsh:QH301-705.5, MESH: Promoter Regions, Genetic, Regulation of gene expression, MESH: Chromatin Immunoprecipitation, MESH: Nuclear Proteins/metabolism, 0303 health sciences, MESH: Histones/metabolism, Reverse Transcriptase Polymerase Chain Reaction, MESH: Proteomics, 030302 biochemistry & molecular biology, High-Throughput Nucleotide Sequencing, Nuclear Proteins, Chromatin, 3. Good health, DNA-Binding Proteins, MESH: Staining and Labeling, Histone, Toxoplasma, MESH: Nuclear Proteins/genetics, Cell Nucleolus, Research Article, lcsh:Immunologic diseases. Allergy, Chromatin Immunoprecipitation, Immunology, MESH: Protozoan Proteins/genetics, MESH: Microscopy, Electron, Biology, MESH: DNA-Binding Proteins/metabolism, Microbiology, MESH: Toxoplasma/metabolism, Tacrolimus Binding Proteins, 03 medical and health sciences, Virology, Genetics, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Nucleosome, MESH: Antibodies, Protozoan, MESH: Regulatory Sequences, Nucleic Acid, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Gene Silencing, Molecular Biology/Chromatin Structure, Molecular Biology, MESH: Protozoan Proteins/metabolism, 030304 developmental biology, MESH: Protozoan Proteins/biosynthesis, MESH: Mass Spectrometry, MESH: DNA-Binding Proteins/genetics, Staining and Labeling, MESH: Nuclear Proteins/biosynthesis, Infectious Diseases/Protozoal Infections, Promoter, Molecular biology, MESH: Tacrolimus Binding Proteins/chemistry, MESH: Cell Nucleolus/genetics, MESH: Nuclear Proteins/chemistry, Microscopy, Electron, lcsh:Biology (General), Molecular Biology/Nucleolus and Nuclear Bodies, MESH: Chromatin/metabolism, biology.protein, Parasitology, MESH: Toxoplasma/genetics, lcsh:RC581-607, Chromatin immunoprecipitation, Ribosomes
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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329b799eb81cff83b5f39da58b88ce5bTest
http://europepmc.org/articles/PMC3068996Test
