المؤلفون: Yajian Duan, Wenyi Wu, Jing Cui, Joanne Aiko Matsubara, Andrius Kazlauskas, Gaoen Ma, Xiaorong Li, Hetian Lei

المصدر: BMC Ophthalmology, Vol 23, Iss 1, Pp 1-12 (2023)

مصطلحات موضوعية: Vitreous, Indirect activation, PDGFRβ, Akt, Retinal pigment epithelial cells, Proliferation, Ophthalmology, RE1-994

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2415Test

الوصول الحر: https://doaj.org/article/57d4d7414a144c54ae9ff57857f0c767Test

المؤلفون: Xiang-Yu Lin, Jing-Yu Li, Ming-Yu Qi, Zi-Rong Tang, Yi-Jun Xu

المصدر: Catalysis Communications, Vol 159, Iss , Pp 106346- (2021)

مصطلحات موضوعية: Methane conversion, Photocatalysis, Direct activation, Indirect activation, Chemistry, QD1-999

العلاقة: http://www.sciencedirect.com/science/article/pii/S1566736721000698Test; https://doaj.org/toc/1873-3905Test; https://doaj.org/article/08a542e081f54a8a9aea83caa1651903Test

الإتاحة: https://doi.org/10.1016/j.catcom.2021.106346Test
https://doaj.org/article/08a542e081f54a8a9aea83caa1651903Test

المؤلفون: Ming-Yu Qi, Jing-Yu Li, Yi-Jun Xu, Xiang-Yu Lin, Zi-Rong Tang

المصدر: Catalysis Communications, Vol 159, Iss, Pp 106346-(2021)

مصطلحات موضوعية: Reaction conditions, Reaction mechanism, Materials science, Process Chemistry and Technology, Dry gas, Direct activation, General Chemistry, Energy consumption, Indirect activation, Catalysis, Methane, chemistry.chemical_compound, Chemistry, chemistry, Chemical engineering, Photocatalysis, Partial oxidation, Methane conversion, QD1-999

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e702b022e90bfa250caff07e8fb3782Test
http://www.sciencedirect.com/science/article/pii/S1566736721000698Test

المؤلفون: Xu Luo, Katelyn L. O'Neill, Kai Huang

المصدر: F1000Research

مصطلحات موضوعية: BH3 mimetics, Cell, Apoptosis, Bcl-xL, Review, Mutually exclusive events, General Biochemistry, Genetics and Molecular Biology, Membrane-mediated Spontaneous activation, Bid, Bcl-2 family, medicine, Bad, Activator, Humans, Bim, General Pharmacology, Toxicology and Pharmaceutics, retro-translocation, bcl-2-Associated X Protein, Mitochondrial outer membrane permeabilization, General Immunology and Microbiology, biology, Effector, Chemistry, Activator (genetics), BH3-only proteins, Bak, Direct activation, Mcl-1, Articles, General Medicine, Indirect activation, Cell biology, Sensitizer, de novo activation, Mitochondrial outer membrane, bcl-2 Homologous Antagonist-Killer Protein, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, Bax, biology.protein, biological phenomena, cell phenomena, and immunity, auto-activation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0434affb0eb4fe195a5c3717977f4b7cTest
https://doi.org/10.12688/f1000research.25607.1Test

المؤلفون: Ana Cabranes, Javier Fernández-Ruiz, Leyre Mestre, Filomena Fezza, Marta Valenti, Vincenzo Di Marzo, Katerina Venderova, Antonio García-Merino, Eva de Lago, José A. Ramos, Antonio Sánchez

المساهمون: Instituto de Salud Carlos III, Ministerio de Ciencia y Tecnología (España), Fundación Centro de Investigación de Enfermedades Neurológicas, Ministero dell'Istruzione, dell'Università e della Ricerca, Fondazione Italiana Sclerosi Multipla, Comunidad de Madrid, Universidad Complutense de Madrid

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Neurobiology of Disease, Vol 20, Iss 2, Pp 207-217 (2005)

مصطلحات موضوعية: the direct or indirect activation of vanilloid or cannabinoid receptors may reduce the neurological impairment experienced by EAE rats, Male, Cannabinoid receptor, we explored the potential changes in several neurotransmitters in the basal ganglia that might be associated with the motor disturbances described in these rats, Phosphodiesterase Inhibitors, medicine.medical_treatment, Gene Expression, we examined whether EAE rats also exhibited changes in endocannabinoid levels as shown for CB1 receptors. Anandamide and 2-arachidonoylglycerol levels decreased in motor related regions (striatum, although the efficacy of the different compounds examined seems to be determined by their particular pharmacodynamic and pharmacokinetic characteristics, and OMDM2 were effective to reduce the magnitude of the neurological impairment in EAE rats, a role for CB1 receptors is supported by additional data showing that CP55, but not by blocking CB1 receptors with SR141716, Basal Ganglia, arvanil, an inhibitor of type IV phosphodiesterase able to supress EAE in different species. Rolipram attenuated clinical decline, chemistry.chemical_compound, Receptor, Cannabinoid, CB1, pain, Receptors, Cannabinoid, although the pattern of changes for each endocannabinoid was different. Finally, EAE, musculoskeletal, neural, and ocular physiology, as a way to explain the efficacy of cannabinoid compounds to alleviate spasticity, Experimental autoimmune encephalomyelitis, Brain, we hypothesized that the elevation of the endocannabinoid activity, and normalized CB1 receptor gene expression in the basal ganglia. As a third objective, an animal model of multiple sclerosis, reduced motor inhibition, Endocannabinoid system, Neurology, AM404, following inhibition of endocannabinoid uptake, lipids (amino acids, peptides, and proteins), might be beneficial in EAE rats. AM404, Rolipram, medicine.drug, medicine.medical_specialty, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Polyunsaturated Alkamides, using the same model, TRPV1, TRPV Cation Channels, and other signs of this autoimmune disease. Using Lewis rats with experimental autoimmune encephalomyelitis (EAE), Arachidonic Acids, Biology, Depolarization-induced suppression of inhibition, Recent studies have addressed the changes in endocannabinoid ligands and receptors that occur in multiple sclerosis, as a way to explain the efficacy of cannabinoid compounds to alleviate spasticity, pain, tremor, and other signs of this autoimmune disease. Using Lewis rats with experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, we recently found a decrease in cannabinoid CB1 receptors mainly circumscribed to the basal ganglia, which could be related to the motor disturbances characteristic of these rats. In the present study, using the same model, we explored the potential changes in several neurotransmitters in the basal ganglia that might be associated with the motor disturbances described in these rats, but we only found a small increase in glutamate contents in the globus pallidus. We also examined whether the motor disturbances and the changes of CB1 receptors found in the basal ganglia of EAE rats disappear after the treatment with rolipram, an inhibitor of type IV phosphodiesterase able to supress EAE in different species. Rolipram attenuated clinical decline, reduced motor inhibition, and normalized CB1 receptor gene expression in the basal ganglia. As a third objective, we examined whether EAE rats also exhibited changes in endocannabinoid levels as shown for CB1 receptors. Anandamide and 2-arachidonoylglycerol levels decreased in motor related regions (striatum, midbrain) but also in other brain regions, although the pattern of changes for each endocannabinoid was different. Finally, we hypothesized that the elevation of the endocannabinoid activity, following inhibition of endocannabinoid uptake, might be beneficial in EAE rats. AM404, arvanil, and OMDM2 were effective to reduce the magnitude of the neurological impairment in EAE rats, whereas VDM11 did not produce any effect. The beneficial effects of AM404 were reversed by blocking TRPV1 receptors with capsazepine, but not by blocking CB1 receptors with SR141716, thus indicating the involvement of endovanilloid mechanisms in these effects. However, a role for CB1 receptors is supported by additional data showing that CP55,940 delayed EAE progression. In summary, our data suggest that reduction of endocannabinoid signaling is associated with the development of EAE in rats. We have also proved that the reduction of CB1 receptors observed in these rats is corrected following treatment with a compound used in EAE such as rolipram. In addition, the direct or indirect activation of vanilloid or cannabinoid receptors may reduce the neurological impairment experienced by EAE rats, although the efficacy of the different compounds examined seems to be determined by their particular pharmacodynamic and pharmacokinetic characteristics, lcsh:RC321-571, Glycerides, Multiple sclerosis, Internal medicine, Cannabinoid Receptor Modulators, medicine, Animals, Settore BIO/10, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Cannabinoids, whereas VDM11 did not produce any effect. The beneficial effects of AM404 were reversed by blocking TRPV1 receptors with capsazepine, thus indicating the involvement of endovanilloid mechanisms in these effects. However, our data suggest that reduction of endocannabinoid signaling is associated with the development of EAE in rats. We have also proved that the reduction of CB1 receptors observed in these rats is corrected following treatment with a compound used in EAE such as rolipram. In addition, medicine.disease, tremor, Endocannabinoid uptake inhibitors, but we only found a small increase in glutamate contents in the globus pallidus. We also examined whether the motor disturbances and the changes of CB1 receptors found in the basal ganglia of EAE rats disappear after the treatment with rolipram, Cyclic Nucleotide Phosphodiesterases, Type 4, Rats, we recently found a decrease in cannabinoid CB1 receptors mainly circumscribed to the basal ganglia, Disease Models, Animal, Endocrinology, nervous system, chemistry, 940 delayed EAE progression. In summary, 3',5'-Cyclic-AMP Phosphodiesterases, Rats, Inbred Lew, Recent studies have addressed the changes in endocannabinoid ligands and receptors that occur in multiple sclerosis, which could be related to the motor disturbances characteristic of these rats. In the present study, Cannabinoid, Capsaicin, CB1 receptors, midbrain) but also in other brain regions, Endocannabinoids

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a283f02c528dda2cbfe2f82bbd4ed1c2Test
https://pubmed.ncbi.nlm.nih.gov/16242629Test

المؤلفون: P. Marini, P. Tucci, ROMANELLI, LUCA, VALERI, Daniela, VALERI, Pacifico, PALMERY, Maura

المساهمون: P., Marini, Romanelli, Luca, Valeri, Daniela, P., Tucci, Valeri, Pacifico, Palmery, Maura

مصطلحات موضوعية: acute withdrawal, adenosine a(1)-receptor, adenosine a1-receptor, cholecystokinin, guinea-pig ileum, indirect activation, opioid receptor

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/20609065; info:eu-repo/semantics/altIdentifier/wos/WOS:000278158000010; volume:62; issue:5; firstpage:622; lastpage:632; numberofpages:11; journal:JOURNAL OF PHARMACY AND PHARMACOLOGY; http://hdl.handle.net/11573/366325Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-77952761252; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000278158000010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest; http://www.scopus.com/inward/record.url?eid=2-s2.0-77952761252&partnerID=65&md5=4c74bd56a0a2e9526531d4b050e637a5Test

الإتاحة: https://doi.org/10.1211/jpp/62.05.0010Test
http://hdl.handle.net/11573/366325Test
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000278158000010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest
http://www.scopus.com/inward/record.url?eid=2-s2.0-77952761252&partnerID=65&md5=4c74bd56a0a2e9526531d4b050e637a5Test

المؤلفون: Marini, P., Romanelli, Luca, Valeri, Daniela, Tucci, P., Valeri, Pacifico, Palmery, Maura

مصطلحات موضوعية: acute withdrawal, adenosine a(1)-receptor, adenosine a1-receptor, cholecystokinin, guinea-pig ileum, indirect activation, opioid receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______3686::a618578fdeeb09efc617be97683197f4Test
http://hdl.handle.net/11573/366325Test