المؤلفون: A. L. Ilyushin, I. V. Bogdashin, A. Z. Aleksanyan, V. V. Novikov, L. A. Ashrafyan, А. Л. Илюшин, И. В. Богдашин, А. З. Алексанян, В. В. Новиков, Л. А. Ашрафян

المصدر: Siberian journal of oncology; Том 22, № 4 (2023); 118-127 ; Сибирский онкологический журнал; Том 22, № 4 (2023); 118-127 ; 2312-3168 ; 1814-4861

مصطلحات موضوعية: PD-1, immune response, antitumor therapy, immuno-oncological drugs, tumor growth control, tumor immuno-editing, antitumor immunity, immunotherapy, иммунный ответ, противоопухолевая терапия, иммуноонкологические препараты, контроль опухолевого роста, иммуноредактирование опухоли, противоопухолевый иммунитет, иммунотерапия

وصف الملف: application/pdf

العلاقة: https://www.siboncoj.ru/jour/article/view/2687/1146Test; Mandai M., Hamanishi J., Abiko K., Matsumura N., Baba T., Konishi I. Dual Faces of IFNγ in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity. Clin Cancer Res. 2016; 22(10): 2329–34. doi:10.1158/1078-0432.CCR-16-0224.; Mendoza J.L., Escalante N.K., Jude K.M., Sotolongo Bellon J., Su L., Horton T.M., Tsutsumi N., Berardinelli S.J., Haltiwanger R.S., Piehler J., Engleman E.G., Garcia K.C. Structure of the IFNγ receptor complex guides design of biased agonists. Nature. 2019; 567 (7746): 56–60. doi:10.1038/s41586-019-0988-7.; Burke J.D., Young H.A. IFN-γ: A cytokine at the right time, is in the right place. Semin Immunol. 2019; 43. doi:10.1016/j.smim.2019.05.002.; Alspach E., Lussier D.M., Schreiber R.D. Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity. Cold Spring Harb Perspect Biol. 2019; 11(3): 1–20. doi:10.1101/cshperspect.a028480.; Schmiedel B.J., Singh D., Madrigal A., Valdovino-Gonzalez A.G., White B.M., Zapardiel-Gonzalo J., Ha B., Altay G., Greenbaum J.A., McVicker G., Seumois G., Rao A., Kronenberg M., Peters B., Vijayanand P. Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression. Cell. 2018; 175(6): 1701–15. doi:10.1016/j.cell.2018.10.022.; Negishi H., Tadatsugu T., Yanai H. The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family. Cold Spring Harb Perspect Biol. 2017; 10(11): 1–15. doi:10.1101/cshperspect.a028423.; Jorgovanovic D., Song M., Wang L., Zhang Y. Roles of IFN-γ in tumor progression and regression: a review. Biomark Res. 2020; 8; 49. doi:10.1186/s40364-020-00228-x.; Song M., Ping Y., Zhang K., Yang L., Li F., Zhang C., Cheng S., Yue D., Maimela N.R., Qu J., Liu S., Sun T., Li Z., Xia J., Zhang B., Wang L., Zhang Y. Low-Dose IFNγ Induces Tumor Cell Stemness in Tumor Microenvironment of Non-Small Cell Lung Cancer. Cancer Res. 2019; 79(14): 3737–48. doi:10.1158/0008-5472.CAN-19-0596.; Zaidi M.R. The Interferon-Gamma Paradox in Cancer. J Interferon Cytokine Res. 2019; 39(1): 30–8. doi:10.1089/jir.2018.0087.; Mojic M., Takeda K., Hayakawa Y. The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion. Int J Mol Sci. 2018; 19(1): 89. doi:10.3390/ijms19010089.; Kang K., Park S.H., Chen J., Qiao Y., Giannopoulou E., Berg K., Hanidu A., Li J., Nabozny G., Kang K., Park-Min K.H., Ivashkiv L.B. Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF. Immunity. 2017; 47(2): 235–50. doi:10.1016/j.immuni.2017.07.017.; Bhat P., Leggatt G., Waterhouse N., Frazer I.H. Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Cell Death Dis. 2017; 8(6). doi:10.1038/cddis.2017.67.; Paul S., Chhatar S., Mishra A., Lal G. Natural killer T cell activation increases iNOS+CD206-M1 macrophage and controls the growth of solid tumor. J Immunother Canc. 2019; 7(1): 1–13. doi:10.1186/s40425-019-0697-7.; Fang P., Li X., Dai J., Cole L., Camacho J.A., Zhang Y., Ji Y., Wang J., Yang X.F., Wang H. Immune cell subset diferentiation and tissue infammation. J Hematol Oncol. 2018; 11(1): 97. doi:10.1186/s13045-018-0637-x.; Ni L., Lu J. Interferon gamma in cancer immunotherapy. Cancer Med. 2018; 7: 4509–16. doi:10.1002/cam4.1700.; Gocher A.M., Workman C.J., Vignali D.A.A. Interferon-γ: teammate or opponent in the tumour microenvironment? Nat Rev Immunol. 2022; 22(3): 158–72. doi:10.1038/s41577-021-00566-3.; Ong C., Lyons A.B., Woods G.M., Flies A.S. Inducible IFN- γ expression for MHC-I upregulation in devil facial tumor cells. Front Immunol. 2019; 9: 1–9. doi:10.3389/fmmu.2018.03117.; Wang Q.S., Shen S.Q., Sun H.W., Xing Z.X., Yang H.L. Interferongamma induces autophagy-associated apoptosis through in-duction of cPLA2- dependent mitochondrial ROS generation in colorectal cancer cells. Biochem Biophys Res Commun. 2018; 498(4): 1058–65. doi:10.1016/j.bbrc.2018.03.118.; Spear P., Barber A., Rynda-Apple A., Sentman C.L. Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-gamma and GM-CSF. J Immunol. 2012; 188: 6389‐98. doi:10.4049/jimmunol.1103019.; Fang C., Weng T., Hu S., Yuan Z., Xiong H., Huang B., Cai Y., Li L., Fu X. IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells. Oncoimmunology. 2021; 10(1). doi:10.1080/2162402X.2021.1962591.; Kammertoens T., Friese C., Arina A., Idel C., Briesemeister D., Rothe M., Ivanov A., Szymborska A., Patone G., Kunz S., Sommermeyer D., Engels B., Leisegang M., Textor A., Fehling H.J., Fruttiger M., Lohoff M., Herrmann A., Yu H., Weichselbaum R., Uckert W., Hübner N., Gerhardt H., Beule D., Schreiber H., Blankenstein T. Tumour ischaemia by interferon-γ resembles physiological blood vessel regression. Nature. 2017; 545(7652): 98–102. doi:10.1038/nature22311.; Liu Y., Liang X., Yin X., Lv J., Tang K., Ma J., Ji T., Zhang H., Dong W., Jin X., Chen D., Li Y., Zhang S., Xie H.Q., Zhao B., Zhao T., Lu J., Hu Z.W., Cao X., Qin F.X., Huang B. Blockade of IDO-kynurenineAhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Nat Commun. 2017; 8. doi:10.1038/ncomms15207.; Glasner A., Levi A., Enk J., Isaacson B., Viukov S., Orlanski S., Scope A., Neuman T., Enk C.D., Hanna J.H., Sexl V., Jonjic S., Seliger B., Zitvogel L., Mandelboim O. NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Immunity. 2018; 48(1): 107–19. doi:10.1016/j.immuni.2017.12.007. Erratum in: Immunity. 2018; 48(2): 396–8.; Исаева В.Г., Гривцова Л.Ю., Жовтун Л.П., Самборский С.М., Фалалеева Н.А. Противоопухолевый эффект рекомбинантного интерферона гамма в экспериментальной модели билатеральной солидной карциномы Эрлиха. Успехи молекулярной онкологии. 2022; 9(2): 111–9. doi: 10.10.17650/2313-805X-2022‑9‑2‑111‑119.; Kaplan D.H., Shankaran V., Dighe A.S., Stockert E., Aguet M., Old L.J., Schreiber R.D. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA. 1998; 95(13): 7556–61. doi:10.1073/pnas.95.13.7556.; Mucci A., Antonarelli G., Caserta C., Vittoria F.M., Desantis G., Pagani R., Greco Be, Casucci M., Escobar G., Passerini L., Lachmann N., Sanvito F., Barcella M., Merelli I., Naldini L., Gentner B. Myeloid cellbased delivery of IFN-γ reprograms the leukemia microenvironment and induces anti-tumoral immune responses. EMBO Mol Med. 2021; 13(10). doi:10.15252/emmm.202013598.; Lo U.G., Pong R.C., Yang D., Gandee L., Hernandez E., Dang A., Lin C.J., Santoyo J., Ma S., Sonavane R., Huang J., Tseng S.F., Moro L., Arbini A.A., Kapur P., Raj G.V., He D., Lai C.H., Lin H., Hsieh J.T. IFNγInduced IFIT5 Promotes Epithelial-to-Mesenchymal Transition in Prostate Cancer via miRNA Processing. Cancer Res. 2019; 79(6): 1098–112. doi:10.1158/0008-5472.CAN-18-2207.; Lo U.G., Bao J., Cen J., Yeh H.C., Luo J., Tan W., Hsieh J.T. Interferon-induced IFIT5 promotes epithelial-to-mesenchymal transition leading to renal cancer invasion. Am J Clin Exp Urol. 2019; 7(1): 31–45.; Korentzelos D., Wells A., Clark A.M. Interferon-γ increases sensitivity to chemotherapy and provides immunotherapy targets in models of metastatic castration-resistant prostate cancer. Sci Rep. 2022; 12(1): 6657. doi:10.1038/s41598-022-10724-9.; Xu Y.H., Li Z.L., Qiu S.F. IFN-γ Induces Gastric Cancer Cell Proliferation and Metastasis Through Upregulation of Integrin β3-Mediated NF-κB Signaling. Transl Oncol. 2018; 11(1): 182–92. doi:10.1016/j.tranon.2017.11.008.; Dillinger B., Ahmadi-Erber S., Lau M., Hoelzl M.A., Erhart F., Juergens B., Fuchs D., Heitger A., Ladisch S., Dohnal A.M. IFN-γ and tumor gangliosides: implications for the tumor microenvironment. Cell Immunol. 2018; 325: 33–40. doi:10.1016/j.cellimm.2018.01.014.; Tong S., Cinelli M.A., El-Sayed N.S., Huang H., Patel A., Silverman R.B., Yang S. Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS). Sci Rep. 2022; 12(1): 1701. doi:10.1038/s41598-022-05394-6.; Talmadge J.E., Black P.L., Tribble H., Pennington R., Bowersox O., Schneider M., Phillips H. Preclinical approaches to the treatment of metastatic disease: therapeutic properties of rH TNF, rM IFN-gamma, and rH IL-2. Drugs Exp Clin Res. 1987; 13(6): 327–37.; Giannopoulos A., Constantinides C., Fokaeas E., Stravodimos C., Giannopoulou M., Kyroudi A., Gounaris A. The immunomodulating efect of interferon-gamma intravesical instillations in preventing bladder cancer recurrence. Clin Cancer Res. 2003; 9(15): 5550–8.; Marth C., Windbichler G.H., Hausmaninger H., Petru E., Estermann K., Pelzer A., Mueller-Holzner E. Interferon-gamma in combination with carboplatin and paclitaxel as a safe and efective frst-line treatment option for advanced ovarian cancer: results of a phase I/II study. Int J Gynecol Cancer. 2006; 16(4): 1522–8. doi:10.1111/j.1525-1438.2006.00622.x.; Пыльцин С.П., Златник Е.Ю., Лазутин Ю.Н., Сергостьянц Г.З., Закора Г.И., Лейман И.А., Анистратов П.А. Влияние ингарона на иммунный статус больных аденокарциномой легкого в процессе адъювантного лечения. Медицинская иммунология. 2014; 16(6): 559–66. doi:10.15789/1563-0625-2014-6-559-566.; Арджа А.Ю., Непомнящая Е.М., Златник Е.Ю., Ульянова Е.П., Вереникина Е.В., Женило О.Е., Никитина В.П., Меньшенина А.П., Сагакянц А.Б., Черникова Е.Н., Якубова Д.Ю., Шульгина О.Г. Особенности экспрессии некоторых иммуногистохимических маркеров у больных раком яичников IIIC-IV стадии как критерий эффективности применения химиоиммунотерапии. Наука молодых. 2020; 8(4): 582–90. doi:10.23888/HMJ202084582-590.; Thibaut R., Bost P., Milo I., Cazaux M., Lemaître F., Garcia Z., Amit I., Breart B., Cornuot C., Schwikowski B., Bousso P. Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment. Nat Cancer. 2020; 1(3): 302–14. doi:10.1038/s43018-020-0038-2.; Garris C.S., Arlauckas S.P., Kohler R.H., Trefny M.P., Garren S., Piot C., Engblom C., Pfrschke C., Siwicki M., Gungabeesoon J., Freeman G.J., Warren S.E., Ong S., Browning E., Twitty C.G., Pierce R.H., Le M.H., Algazi A.P., Daud A.I., Pai S.I., Zippelius A., Weissleder R., Pittet M.J. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018; 49(6): 1148–61. doi:10.1016/j.immuni.2018.09.024.; Park A., Yang Y., Lee Y., Kim M.S., Park Y.J., Jung H., Kim T.D., Lee H.G., Choi I., Yoon S.R. Indoleamine-2,3-Dioxygenase in Thyroid Cancer Cells Suppresses Natural Killer Cell Function by Inhibiting NKG2D and NKp46 Expression via STAT Signaling Pathways. J Clin Med. 2019; 8(6): 842. doi:10.3390/jcm8060842.; Xu Y.P., Lv L., Liu Y., Smith M.D., Li W.C., Tan X.M., Cheng M., Li Z., Bovino M., Aubé J., Xiong Y. Tumor suppressor TET2 promotes cancer immunity and immunotherapy efcacy. J Clin Invest. 2019; 129(10): 4316–31. doi:10.1172/JCI129317.; Mimura K., Teh J.L., Okayama H., Shiraishi K., Kua L.F., Koh V., Smoot D.T., Ashktorab H., Oike T., Suzuki Y., Fazreen Z., Asuncion B.R., Shabbir A., Yong W.P., So J., Soong R., Kono K. PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci. 2018; 109(1): 43–53. doi:10.1111/cas.13424.; Sceneay J., Goreczny G.J., Wilson K., Morrow S., DeCristo M.J., Ubellacker J.M., Qin Y., Laszewski T., Stover D.G., Barrera V., Hutchinson J.N., Freedman R.A., Mittendorf E.A., McAllister S.S. Interferon Signaling Is Diminished with Age and Is Associated with Immune Checkpoint Blockade Efcacy in Triple-Negative Breast Cancer. Cancer Discov. 2019; 9(9): 1208–27. doi:10.1158/2159-8290.CD-18-1454.; Gao J., Shi L.Z., Zhao H., Chen J., Xiong L., He Q., Chen T., Roszik J., Bernatchez C., Woodman S.E., Chen P.L., Hwu P., Allison J.P., Futreal A., Wargo J.A., Sharma P. Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell. 2016; 167(2): 397–404. doi:10.1016/j.cell.2016.08.069.; Grasso C.S., Tsoi J., Onyshchenko M., Abril-Rodriguez G., Ross-Macdonald P., Wind-Rotolo M., Champhekar A., Medina E., Torrejon D.Y., Shin D.S., Tran P., Kim Y.J., Puig-Saus C., Campbell K., Vega-Crespo A., Quist M., Martignier C., Luke J.J., Wolchok J.D., Johnson D.B., Chmielowski B., Hodi F.S., Bhatia S., Sharfman W., Urba W.J., Slingluff C.L. Jr., Diab A., Haanen J.B.A.G., Algarra S.M., Pardoll D.M., Anagnostou V., Topalian S.L., Velculescu V.E., Speiser D.E., Kalbasi A., Ribas A. Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma. Cancer Cell. 2020; 38(4): 500–15. doi:10.1016/j.ccell.2020.08.005.; Zhang M., Huang L., Ding G., Huang H., Cao G., Sun X., Lou N., Wei Q., Shen T., Xu X., Cao L., Yan Q. Interferon gamma inhibits CXCL8-CXCR2 axis mediated tumor-associated macrophages tumor trafcking and enhances anti-PD1 efcacy in pancreatic cancer. J Immunother Cancer. 2020; 8(1). doi:10.1136/jitc-2019-000308.; Zhang S., Kohli K., Black R.G., Yao L., Spadinger S.M., He Q., Pillarisetty V.G., Cranmer L.D., Van Tine B.A., Yee C., Pierce R.H., Riddell S.R., Jones R.L., Pollack S.M. Systemic Interferon-γ Increases MHC Class I Expression and T-cell Infltration in Cold Tumors: Results of a Phase 0 Clinical Trial. Cancer Immunol Res. 2019; 7(8): 1237–43. doi:10.1158/2326-6066.CIR-18-0940.; Ayers M., Lunceford J., Nebozhyn M., Murphy E., Loboda A., Kaufman D.R., Albright A., Cheng J.D., Kang S.P., Shankaran V., Piha-Paul S.A., Yearley J., Seiwert T.Y., Ribas A., McClanahan T.K. IFN-γ-related mRNA profle predicts clinical response to PD-1 blockade. J Clin Invest. 2017; 127(8): 2930–40. doi:10.1172/JCI91190.; Higgs B.W., Morehouse C.A., Streicher K., Brohawn P.Z., Pilataxi F., Gupta A., Ranade K. Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab. Clin Cancer Res. 2018; 24(16): 3857–66. doi:10.1158/1078-0432.CCR-17-3451.; Liu L., Du X., Fang J., Zhao J., Guo Y., Zhao Y., Zou C., Yan X., Li W. Development of an Interferon Gamma Response-Related Signature for Prediction of Survival in Clear Cell Renal Cell Carcinoma. J Infamm Res. 2021; 14: 4969–85. doi:10.2147/JIR.S334041.; Reijers I.L.M., Dimitriadis P., Rozeman E.A., Krijgsman O., Cornelissen S., Bosch L.J.W., Broeks A., Menzies A., van de Wiel B.A., Scolyer R.A., Long G.V., Blank C.U. The interferon-gamma (IFN-y) signature from baseline tumor material predicts pathologic response after neoadjuvant ipilimumab (IPI) + nivolumab (NIVO) in stage III melanoma. J Clin Oncol. 2022; 40(16): 9539. doi:10.1200/JCO.2022.40.16_suppl.9539.; Cui C., Xu C., Yang W., Chi Z., Sheng X., Si L., Xie Y., Yu J., Wang S., Yu R., Guo J., Kong Y. Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma. NPJ Genom Med. 2021; 6(1): 7. doi:10.1038/s41525-021-00169-w.; Tecalco-Cruz A.C., Macías-Silva M., Ramírez-Jarquín J.O., Méndez-Ambrosio B. Identifcation of genes modulated by interferon gamma in breast cancer cells. Biochem Biophys Rep. 2021; 27. doi:10.1016/j.bbrep.2021.101053.; Boutsikou E., Domvri K., Hardavella G., Tsiouda D., Zarogoulidis K., Kontakiotis T. Tumour necrosis factor, interferon-gamma and interleukins as predictive markers of antiprogrammed cell-death protein-1 treatment in advanced non-small cell lung cancer: a pragmatic approach in clinical practice. Ther Adv Med Oncol. 2018; 10: 1–8. doi:10.1177/1758835918768238.; https://www.siboncoj.ru/jour/article/view/2687Test

الإتاحة: https://doi.org/10.21294/1814-4861-2023-22-4-118-127Test
https://doi.org/10.1158/1078-0432.CCR-16-0224Test
https://doi.org/10.1038/s41586-019-0988-7Test
https://doi.org/10.1016/j.smim.2019.05.002Test
https://doi.org/10.1101/cshperspect.a028480Test
https://doi.org/10.1016/j.cell.2018.10.022Test
https://doi.org/10.1101/cshperspect.a028423Test
https://doi.org/10.1186/s40364-020-00228-xTest
https://doi.org/10.1158/0008-5472.CAN-19-0596Test
https://doi.org/10.1089/jir.2018.0087Test

المؤلفون: Richa Gulati, Dhruva Nandi, Koustav Sarkar, P. Venkataraman, K. M. Ramkumar, Priya Ranjan, Rajiv Janardhanan

المصدر: Frontiers in Molecular Biosciences, Vol 9 (2022)

مصطلحات موضوعية: exosomes, tumour etiopathology, cancer immuno-editing, theranostics (combined therapeutic and diagnostic technology), clinical prognosis, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmolb.2022.890768/fullTest; https://doaj.org/toc/2296-889XTest

الوصول الحر: https://doaj.org/article/981fd549d67346dc86a0a780c164dadeTest

المؤلفون: Morten Orebo Holmström, Mads Hald Andersen

المصدر: Cancers; Volume 12; Issue 10; Pages: 3045

مصطلحات موضوعية: RAS, immuno-editing, immune surveillance, T cell memory, neo-antigens

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/cancers12103045Test

الإتاحة: https://doi.org/10.3390/cancers12103045Test

المؤلفون: Holmström, Morten Orebo, Andersen, Mads Hald

المصدر: Holmström , M O & Andersen , M H 2020 , ' Healthy donors harbor memory T cell responses to RAS neo-antigens ' , Cancers , vol. 12 , no. 10 , 3045 , pp. 1-16 . https://doi.org/10.3390/cancers12103045Test

مصطلحات موضوعية: Immune surveillance, Immuno-editing, Neo-antigens, RAS, T cell memory

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.3390/cancers12103045Test
https://curis.ku.dk/portal/da/publications/healthy-donors-harbor-memory-t-cell-responses-to-ras-neoantigensTest(f90a572b-5e9d-49f7-9116-b87d20abe702).html
https://curis.ku.dk/ws/files/256216075/cancers_12_03045_v2.pdfTest

المؤلفون: Davide Valentini, Martin Rao, Lalit Rane, Sayma Rahman, Rebecca Axelsson-Robertson, Rainer Heuchel, Matthias Löhr, Daniel Hoft, Susanna Brighenti, Alimuddin Zumla, Markus Maeurer

المصدر: International Journal of Infectious Diseases, Vol 56, Iss C, Pp 140-154 (2017)

مصطلحات موضوعية: Peptide microarray, Bacille Calmette–Guérin, Immuno-editing, Immunoglobulin gamma, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1201971217300309Test; https://doaj.org/toc/1201-9712Test; https://doaj.org/toc/1878-3511Test

الوصول الحر: https://doaj.org/article/99991500ccf84e228d53eb86783f4dedTest

المؤلفون: Valentini, D, Rao, M, Rane, L, Rahman, S, Axelsson-Robertson, R, Heuchel, R, Lohr, M, Hoft, D, Brighenti, S, Zumla, A, Maeurer, M

المصدر: International Journal of Infectious Diseases , 56 pp. 140-154. (2017)

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Peptide Microarray, Bacille Calmette-Guerin, Immuno-Editing, Immunoglobulin Gamma, Growth-Factor-Beta, Mycobacterium-Tuberculosis Infection, T-Cells, B-Cells, Pulmonary Tuberculosis, Immune-Responses, Bcg Vaccination, Expression, Recognition, Profiles

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/1551434/1/Zumla__Zumla_1-s2.0-S1201971217300309-main%20%281%29.pdfTest; https://discovery.ucl.ac.uk/id/eprint/1551434Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/1551434/1/Zumla__Zumla_1-s2.0-S1201971217300309-main%20%281%29.pdfTest
https://discovery.ucl.ac.uk/id/eprint/1551434Test/

المؤلفون: Holmström, Morten Orebo, Cordua, Sabrina, Skov, Vibe, Kjær, Lasse, Pallisgaard, Niels, Ellervik, Christina, Hasselbalch, Hans Carl, Andersen, Mads Hald

المصدر: Holmström , M O , Cordua , S , Skov , V , Kjær , L , Pallisgaard , N , Ellervik , C , Hasselbalch , H C & Andersen , M H 2020 , ' Evidence of immune elimination, immuno-editing and immune escape in patients with hematological cancer ' , Cancer Immunology, Immunotherapy , vol. 69 , pp. 315–324 . https://doi.org/10.1007/s00262-019-02473-yTest

مصطلحات موضوعية: CALR, CITIM 2019, Immuno-editing, Myeloproliferative neoplasms, Neo-antigen, T cell memory

الإتاحة: https://doi.org/10.1007/s00262-019-02473-yTest
https://curis.ku.dk/portal/da/publications/evidence-of-immune-elimination-immunoediting-and-immune-escape-in-patients-with-hematological-cancerTest(a3de1ffd-44fd-4024-ad1e-67b5997bd1b7).html

المؤلفون: Al-Tameemi Mohannad, Chaplain Mark, d’Onofrio Alberto

المصدر: Biology Direct, Vol 7, Iss 1, p 31 (2012)

مصطلحات موضوعية: Tumour growth, Immune response, Cytotoxic T-lymphocytes, Immuno-evasion, Mathematical models, Chemotaxis, Diffusion, Immuno-editing, Biology (General), QH301-705.5

العلاقة: https://doaj.org/toc/1745-6150Test; https://doaj.org/article/b55cced618b14e1ebe93ef2d825d9eddTest

الإتاحة: https://doi.org/10.1186/1745-6150-7-31Test
https://doaj.org/article/b55cced618b14e1ebe93ef2d825d9eddTest

المؤلفون: Rainer Heuchel, Daniel F. Hoft, Lalit Rane, Alimuddin Zumla, Sayma Rahman, Martin Rao, Davide Valentini, Markus Maeurer, Rebecca Axelsson-Robertson, Matthias Löhr, Susanna Brighenti

المصدر: International Journal of Infectious Diseases, Vol 56, Iss C, Pp 140-154 (2017)

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), medicine.medical_treatment, Protein Array Analysis, Immuno-editing, lcsh:Infectious and parasitic diseases, Immunoglobulin gamma, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cell surface receptor, Interleukin-4 receptor, medicine, Humans, Tuberculosis, lcsh:RC109-216, Amino Acid Sequence, Receptor, Autoantibodies, Peptide microarray, biology, Vaccination, Bacille Calmette–Guérin, General Medicine, Immunotherapy, Mycobacterium bovis, Immunity, Humoral, 030104 developmental biology, Infectious Diseases, Antibody Formation, Immunology, BCG Vaccine, biology.protein, Antibody, Peptides, BCG vaccine, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ab580de21f7a5b06cee6a276d28f97Test
https://doi.org/10.1016/j.ijid.2017.01.027Test

المؤلفون: Gasparri, Maria Luisa, Ruscito, Ilary, Taghavi, Katayoun, Farooqi, Ammad Ahmad, Papadia, Andrea, Focaccetti, Chiara, Barnaba, Vincenzo, Panici, Pierluigi Benedetti, Mueller, Michael D.

المساهمون: Gasparri, Maria Luisa, Ruscito, Ilary, Taghavi, Katayoun, Farooqi, Ammad Ahmad, Papadia, Andrea, Focaccetti, Chiara, Barnaba, Vincenzo, Panici, Pierluigi Benedetti, Mueller, Michael D.

مصطلحات موضوعية: Gynecologic malignancie, Tumor escape, Immuno-editing, Immunotherapy, Monoclonal antibodie, Cancer vaccine, Checkpoint inhibitor, Cytokines

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-3-319-53081-9; info:eu-repo/semantics/altIdentifier/isbn/978-3-319-53082-6; info:eu-repo/semantics/altIdentifier/wos/WOS:000423235204182; ispartofbook:Molecular Oncology: Underlying Mechanisms and Translational Advancements; firstpage:193; lastpage:204; numberofpages:12; http://hdl.handle.net/11573/1080324Test; https://link.springer.com/content/pdf/10.1007/978-3-319-53082-6_9.pdfTest

الإتاحة: https://doi.org/10.1007/978-3-319-53082-6_9Test
http://hdl.handle.net/11573/1080324Test