المؤلفون: Harsunen, Minna, Kettunen, Jarno L.T., Härkönen, Taina, Dwivedi, Om, Lehtovirta, Mikko, Vähäsalo, Paula, Veijola, Riitta, Ilonen, Jorma, Miettinen, Päivi J., Knip, Mikael, Tuomi, Tiinamaija

المصدر: Diabetologia EXODIAB: Excellence of Diabetes Research in Sweden. 66(3):438-449

مصطلحات موضوعية: Diabetes in childhood, Finnish Pediatric Diabetes Register, Islet cell autoantibodies, MODY, Monogenic forms of diabetes, Next generation sequencing gene panel, Type 1 diabetes-related autoantibodies, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

الوصول الحر: https://lup.lub.lu.se/record/e2f243f0-1b86-4662-870f-6b1646dce6f6Test
http://dx.doi.org/10.1007/s00125-022-05834-yTest

المؤلفون: Starskaia, Inna, Valta, Milla, Pietilä, Sami, Suomi, Tomi, Pahkuri, Sirpa, Kalim, Ubaid Ullah, Rasool, Omid, Rydgren, Emilie, Hyöty, Heikki, Knip, Mikael, Veijola, Riitta, Ilonen, Jorma, Toppari, Jorma, Lempainen, Johanna, Elo, Laura L., Lahesmaa, Riitta

المساهمون: Tampere University, Biosciences, LAST, Paediatrics

مصطلحات موضوعية: 3123 Gynaecology and paediatrics, 3111 Biomedicine

وصف الملف: fulltext

العلاقة: 3810; 15; https://trepo.tuni.fi/handle/10024/159192Test; URN:NBN:fi:tuni-202407087544

الإتاحة: https://doi.org/10.1038/s41467-024-47918-wTest
https://trepo.tuni.fi/handle/10024/159192Test

المؤلفون: Pahkuri, Sirpa, Katayama, Shintaro, Valta, Milla, Nygård, Lucas, Knip, Mikael, Kere, Juha, Ilonen, Jorma, Lempainen, Johanna

المساهمون: Sigrid Juséliuksen Säätiö, Päivikki ja Sakari Sohlbergin Säätiö, Medicinska Understödsföreningen Liv och Hälsa, Hjärnfonden

المصدر: HLA ; volume 103, issue 6 ; ISSN 2059-2302 2059-2310

الإتاحة: https://doi.org/10.1111/tan.15548Test

المؤلفون: HEDIMED Investigator group, Hakola, Leena, Lund-Blix, Nicolai A., Takkinen, Hanna Mari, Tapanainen, Heli, Niinistö, Sari, Korhonen, Tuuli E., Stene, Lars C., Hyöty, Heikki, Toppari, Jorma, Ilonen, Jorma, Knip, Mikael, Veijola, Riitta, Virtanen, Suvi M., Anna, Eurén, Heikki, Hyöty, Kalle, Kurppa, Jutta, Laiho, Olli, Laitinen, Jussi, Lehtonen, Katri, Lindfors, Maria, Lönnrot, Johannes, Malkamäki, Noora, Nurminen, Matti, Nykter, Sami, Oikarinen, Leena, Puustinen, Amirbabak, Sioofy Khojine, Keijo, Viiri, Daniel, Agardh, Andrén, Aronsson Carin, Markus, Lundgren, Iida, Mäkelä, Martin, Romantschuk, Laura, Soininen, Nicolai A, Lund Blix, Maria, Magnus, Aino-Kaisa, Rantala, Lars, Stene, Ketil, Størdal, German, Tapia, Laura, Elo, Sini, Junttila, Riitta, Lahesmaa, Johanna, Lempainen, Robert, Moulder, Omid, Rasool, Tomi, Suomi, Jorma, Toppari, Ubaid, Ullah, Riitta, Veijola

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents

مصطلحات موضوعية: Cohort study, Diabetes mellitus, Type 1, Dietary intake, Gluten, Pregnancy, Prenatal exposure delayed effects, Gynaecology and paediatrics, 3143 Nutrition

وصف الملف: application/pdf

العلاقة: Supported by the Research Council of Finland (grants 63 672, 68 292, 79 685, 79 686, 80 846, 114 666, 126 813, 129 492, 139 391, 201 988, 210 632, 250 114, 276 475, 308 066, 339 922); European Foundation for the Study of Diabetes award supported by EFSD/JDRF/Lilly; the Diabetes Research Foundation; the Juho Vainio Foundation; Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital (grants 9E082, 9F089, 9G087, 9H092, 9J147, 9K149, 9L042, 9L117, 9M036, 9M114, 9N086, 9P057, 9R055, 9S074, 9T072, 9U065, 9V072, 9X062, 9AA084, 9AB083); the Juvenile Diabetes Research Foundation (grants 4-1998-274, 4-1999-731, 4-2001-435, 1-SRA-2016-342-M-R, 1-SRA-2019-732-M-B, and 3-SRA-2020-955-S-B); the Novo Nordisk Foundation; the European Union Biomed 2 Program (BMH4-CT98-3314). This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 874864 HEDIMED.; HEDIMED Investigator group , Hakola , L , Lund-Blix , N A , Takkinen , H M , Tapanainen , H , Niinistö , S , Korhonen , T E , Stene , L C , Hyöty , H , Toppari , J , Ilonen , J , Knip , M , Veijola , R , Virtanen , S M , Anna , E , Heikki , H , Kalle , K , Jutta , L , Olli , L , Jussi , L , Katri , L , Maria , L , Johannes , M , Noora , N , Matti , N , Sami , O , Leena , P , Amirbabak , S K , Keijo , V , Daniel , A , Andrén , A C , Markus , L , Iida , M , Martin , R , Laura , S , Nicolai A , L B , Maria , M , Aino-Kaisa , R , Lars , S , Ketil , S , German , T , Laura , E , Sini , J , Riitta , L , Johanna , L , Robert , M , Omid , R , Tomi , S , Jorma , T , Ubaid , U & Riitta , V 2024 , ' Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child ' , Clinical nutrition espen , vol. 62 , pp. 22-27 . https://doi.org/10.1016/j.clnesp.2024.05.001Test; http://hdl.handle.net/10138/575899Test; 496d44fc-88e5-4b28-96f5-13623a043574; 85192760911

الإتاحة: http://hdl.handle.net/10138/575899Test

المؤلفون: Ludvigsson, Johnny, Von Herrath, Matthias G., Mallone, Roberto, Buschard, Karsten, Cilio, Corrado, Craig, Maria, Ilonen, Jorma, Leslie, David, Mcgeoch, Julie E. M., Schneider, Darius, Skyler, Jay S., Tullberg, Malin Flodström, Hober, Didier

المساهمون: Université de Lille, CHU Lille, Linköping university hospital, La Jolla Institute for Immunology La Jolla, CA, États-Unis, Institut Cochin IC UM3 (UMR 8104 / U1016), Hôpital national = Rigshospitalet Copenhagen, Denmark HNC, Lund University, The University of Sydney, University of Turku, Harvard University, University of Miami, Karolinska Institutet Stockholm, Laboratoire de virologie - ULR 3610

مصطلحات موضوعية: COVID19, public health, economic depression, vulnerable groups, isolation, corona

وصف الملف: application/octet-stream; application/pdf

العلاقة: Frontiers in Public Health; Front. Public Health; http://hdl.handle.net/20.500.12210/102842Test

الإتاحة: https://doi.org/20.500.12210/102842Test
https://hdl.handle.net/20.500.12210/102842Test

المؤلفون: Kyronniemi, Anni, Valtanen, Toni, Koskenniemi, Jaakko, Vähäsalo, Paula, Härkönen, Taina, Ilonen, Jorma, Toppari, Jorma, Knip, Mikael, Veijola, Riitta

المساهمون: Research Programs Unit, Research Group Knip, Molecular and Integrative Biosciences Research Programme, HUS Children and Adolescents, CAMM - Research Program for Clinical and Molecular Metabolism, Lastentautien yksikkö, Children's Hospital, Clinicum

مصطلحات موضوعية: Diabetes autoimmunity, Risk children, Type-1, Antibodies, Birth, Age, Seasonality, Progression, Childhood, Iddm, 3123 Gynaecology and paediatrics

وصف الملف: application/pdf

العلاقة: This study was supported by the Alma and K.A. Snellman Foundation, Oulu, Finland and the Foundation for Pediatric Research, Helsinki, Finland. The DIPP study was supported by the following grants: JDRF (grants 1-SRA-2016-342-M-R, 1-SRA-2019-732-M-B, and 3-SRA-2020-955-S-B); European Commission (grant BMH4-CT98-3314); Novo Nordisk Foundation; Academy of Finland (Decision No. 292538), and Centre of Excellence in Molecular Systems Immunology and Physiology Research 2012-2017 (Decision No. 250114); Special Research Funds for University Hospitals in Finland; Diabetes Research Foundation, Finland; and Sigrid Juselius Foundation, Finland. Authors warmly thank Tytti Pokka from Oulu University Hospital, Department of Pediatrics, for her contribution in data processing. We are grateful to Taru Karjalainen and Mia Laakso for their major contribution in organizing and processing the data on first-degree relatives. All families participating in the DIPP study are acknowledged for their valuable contribution. We also thank the personnel in the clinical study centers and in the genetic and islet autoantibody laboratories for their contribution to the success of the DIPP study.; Kyronniemi , A , Valtanen , T , Koskenniemi , J , Vähäsalo , P , Härkönen , T , Ilonen , J , Toppari , J , Knip , M & Veijola , R 2023 , ' Extremely Early Appearance of Islet Autoantibodies in Genetically Susceptible Children ' , Pediatric Diabetes , vol. 2023 , 9973135 . https://doi.org/10.1155/2023/9973135Test; http://hdl.handle.net/10138/569427Test; 53cf0174-3497-497c-b536-c445aa12a884; 001129213000001

الإتاحة: http://hdl.handle.net/10138/569427Test

المؤلفون: Metsälä, Johanna, Vuorinen, Anna Leena, Takkinen, Hanna Mari, Peltonen, Essi J., Ahonen, Suvi, Åkerlund, Mari, Tapanainen, Heli, Mattila, Markus, Toppari, Jorma, Ilonen, Jorma, Veijola, Riitta, Haahtela, Tari, Knip, Mikael, Kaila, Minna, Virtanen, Suvi M.

المساهمون: Faculty of Social Sciences, Department of Food and Nutrition, HUS Inflammation Center, CAMM - Research Program for Clinical and Molecular Metabolism, University of Helsinki, HUS Children and Adolescents, Children's Hospital, Department of Public Health, Cyanobacteria research

مصطلحات موضوعية: Asthma, Birth cohort, Child, Fruits, Vegetables, 3121 General medicine, internal medicine and other clinical medicine, 3123 Gynaecology and paediatrics

وصف الملف: application/pdf

العلاقة: The study was supported by the Academy of Finland (grants 63672,79685, 79686, 80846, 201988, 210632, 129492, 126813, 276475), the Yrjö Jahnsson Foundation, the Competitive Research Funding of the Tampere University Hospital (grants 9L035, 9M029, 9P017, 9P057, 9R012, 9R055, 9S015, 9S074, 9T072, 9U016, 9U065, 9V012, 9X062, 9AA020), the Medical Research Funds of Turku and Oulu University Hospitals, the European Foundation for the Study of Diabetes (supported by EFSD/JDRF/Lilly, the Juvenile Diabetes Research Foundation (grants 197032, 4–1998‐274, 4–1999‐731, 4–2001‐435, 1‐SRA‐2016‐342‐M‐R, 1–41 SRA‐2019‐732‐M‐B), the Novo Nordisk Foundation and EU Biomed 2 (BMH4‐CT98‐3314), the Sigrid Juselius Foundation, the Doctoral Programs for Public Health, the Foundation for Allergy Research, the Research Foundation of Orion Corporation, the Tampere Tuberculosis Foundation, the Päivikki and Sakari Sohlberg Foundation, and the Jalmari and Rauha Ahokas Foundation. ); Metsälä , J , Vuorinen , A L , Takkinen , H M , Peltonen , E J , Ahonen , S , Åkerlund , M , Tapanainen , H , Mattila , M , Toppari , J , Ilonen , J , Veijola , R , Haahtela , T , Knip , M , Kaila , M & Virtanen , S M 2023 , ' Longitudinal consumption of fruits and vegetables and risk of asthma by 5 years of age ' , Pediatric Allergy and Immunology , vol. 34 , no. 3 , e13932 . https://doi.org/10.1111/pai.13932Test; ORCID: /0000-0002-5658-1305/work/136650438; ORCID: /0000-0002-2779-3384/work/142010643; 85150990023; 546864eb-054e-40a5-a047-6cc0378eb7e2; http://hdl.handle.net/10138/573031Test; 000947729100001

الإتاحة: http://hdl.handle.net/10138/573031Test

المؤلفون: Helminen, Olli, Pokka, Tytti, Aspholm, Susanna, Ilonen, Jorma, Simell, Olli G., Knip, Mikael, Veijola, Riitta

المساهمون: HUS Children and Adolescents, Children's Hospital, Research Programs Unit, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism

مصطلحات موضوعية: Dysglycemia, Glucose metabolism, Islet autoantibodies, Preclinical type 1 diabetes, Type 1 diabetes, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: Helminen , O , Pokka , T , Aspholm , S , Ilonen , J , Simell , O G , Knip , M & Veijola , R 2022 , ' First-emerging islet autoantibody and glucose metabolism : search for type 1 diabetes subtypes ' , Endocrine Connections , vol. 11 , no. 9 , e210632 . https://doi.org/10.1530/EC-21-0632Test; 3cff51be-80a4-4f7c-a6a8-73fe2f6a3976; http://hdl.handle.net/10138/571870Test; 000874901200006

الإتاحة: http://hdl.handle.net/10138/571870Test

المؤلفون: The TEDDY Study Group, Af Segerstad, Elin M. Hard, Liu, Xiang, Uusitalo, Ulla, Toppari, Jorma, Simell, Olli G., Aaltonen, Sanna-Mari, Adamsson, Annika, Ahonen, Suvi, Åkerlund, Mari, Hakola, Leena, Hekkala, Anne, Holappa, Henna, Hyöty, Heikki, Ikonen, Anni, Ilonen, Jorma, Jokipuu, Sanna, Kähönen, Miia, Karlsson, Leena, Kero, Jukka, Knip, Mikael, Koivikko, Minna-Liisa, Kokkonen, Katja, Koreasalo, Mirva, Koskenniemi, Jaakko J., Koskinen, Merja, Kurppa, Kalle, Kuusela, Salla

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents

مصطلحات موضوعية: Hla, Teddy, Celiac disease, Children, Gluten foods, 3143 Nutrition

وصف الملف: application/pdf

العلاقة: Supported in part by NIH/National Center forAdvancing Translational Sciences (NCATS) Clinical and Translational Science Awards UL1 TR000064 (to the University of Florida) and UL1 TR002535 (to the University of Colorado). The TEDDY Study is funded by grants U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, U01 DK124166, and U01 DK128847 and contract no. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases, EuniceKennedy ShriverNational Institute of Child Health and Human Development, National Institute of Environmental Health Sciences, CDC, and JDRF. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.; The TEDDY Study Group , Af Segerstad , E M H , Liu , X , Uusitalo , U , Toppari , J , Simell , O G , Aaltonen , S-M , Adamsson , A , Ahonen , S , Åkerlund , M , Hakola , L , Hekkala , A , Holappa , H , Hyöty , H , Ikonen , A , Ilonen , J , Jokipuu , S , Kähönen , M , Karlsson , L , Kero , J , Knip , M , Koivikko , M-L , Kokkonen , K , Koreasalo , M , Koskenniemi , J J , Koskinen , M , Kurppa , K & Kuusela , S 2022 , ' Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children : The Environmental Determinants of Diabetes in the Young (TEDDY) study ' , American Journal of Clinical Nutrition , vol. 116 , no. 2 , pp. 394-403 . https://doi.org/10.1093/ajcn/nqac086Test; 4f38116e-5ceb-432d-a98c-ad33b3fa5e2f; http://hdl.handle.net/10138/570135Test; 000796675300001

الإتاحة: http://hdl.handle.net/10138/570135Test

المؤلفون: Hirvonen, M. Karoliina, Lietzén, Niina, Moulder, Robert, Bhosale, Santosh D., Koskenniemi, Jaakko, Vähä-Mäkilä, Mari, Nurmio, Mirja, Orešič, Matej, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyöty, Heikki, Lähdesmäki, Harri, Knip, Mikael, Cheng, Lu, Lahesmaa, Riitta

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital

مصطلحات موضوعية: Gynaecology and paediatrics

وصف الملف: application/pdf

العلاقة: The authors are grateful to the DIPP families for their participation and the clinical personnel for excellent collaboration, working with the families and obtaining the samples and clinical data for the study. We also thank the staff of the DIPP Immunogenetics laboratory at University of Turku and the DIPP autoantibody laboratory at University of Oulu. The mass spectrometry analyses presented in this work were performed at the Proteomics Core Facility of the Turku Bioscience Centre that belongs to Biocenter Finland infrastructure network. We thank Pekka Haapaniemi (Proteomics Facility, Turku Bioscience Centre, Finland) for his invaluable help in sample preparation, and also other facility members for the excellent technical support. L. C. and H. L. acknowledges the computational resources provided by the Aalto Science-IT project and CSC—IT Center for Science, Finland. Figure was created with Biorender.com. The authors are grateful to the DIPP families for their participation and the clinical personnel for excellent collaboration, working with the families and obtaining the samples and clinical data for the study. We also thank the staff of the DIPP Immunogenetics laboratory at University of Turku and the DIPP autoantibody laboratory at University of Oulu. The mass spectrometry analyses presented in this work were performed at the Proteomics Core Facility of the Turku Bioscience Centre that belongs to Biocenter Finland infrastructure network. We thank Pekka Haapaniemi (Proteomics Facility, Turku Bioscience Centre, Finland) for his invaluable help in sample preparation, and also other facility members for the excellent technical support. L. C. and H. L. acknowledges the computational resources provided by the Aalto Science-IT project and CSC—IT Center for Science, Finland. Figure 1 was created with Biorender.com.; Hirvonen , M K , Lietzén , N , Moulder , R , Bhosale , S D , Koskenniemi , J , Vähä-Mäkilä , M , Nurmio , M , Orešič , M , Ilonen , J , Toppari , J , Veijola , R , Hyöty , H , Lähdesmäki , H , Knip , M , Cheng , L & Lahesmaa , R 2023 , ' Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes ' , Scientific Reports , vol. 13 , no. 1 , 15941 . https://doi.org/10.1038/s41598-023-43039-4Test; http://hdl.handle.net/10138/569639Test; f7c92475-6b63-441d-90c6-f70646434629; 85171842365

الإتاحة: http://hdl.handle.net/10138/569639Test