Justification of Genetic Factors for Predicting the Risk of Acute Bleeding in Peptic Ulcer Disease
| العنوان: | Justification of Genetic Factors for Predicting the Risk of Acute Bleeding in Peptic Ulcer Disease |
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| المؤلفون: | Yuriy Mykolayovych Myshkovskii, Ihor Ivanovich Bilyk, Michael Ivanovich Sheremet, Volodymyr Volodymyrovich Tarabanchuk, Ivan Ivanovich Dutka, Fedir Vasilyevich Grynchuk, Iryna Ihorivna Panchuk, Vitaliy Vasilyevich Maksymyuk, R. A. Volkov |
| المصدر: | Journal of Medicine and Life |
| بيانات النشر: | Carol Davila University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Peptic Ulcer, Perforation (oil well), ulcer bleeding, Hemorrhage, Disease, 030204 cardiovascular system & hematology, Gastroenterology, Polymorphism, Single Nucleotide, predictors of recurrent ulcerative bleeding, 03 medical and health sciences, Young Adult, 0302 clinical medicine, gene PAI-1 (SERPINE 1), Risk Factors, Internal medicine, Genotype, Plasminogen Activator Inhibitor 1, medicine, Humans, In patient, Genetic Predisposition to Disease, Allele, Genotyping, Aged, Aged, 80 and over, peptic ulcer disease, business.industry, General Medicine, prediction, Acute bleeding, Middle Aged, medicine.disease, digestive system diseases, Peptic ulcer, Acute Disease, recurrent ulcerative bleeding, 030211 gastroenterology & hepatology, Original Article, Female, business, Gastrointestinal Hemorrhage |
| الوصف: | PAI genotyping for the G43A and 4G/5G polymorphisms was performed in 60 patients with peptic ulcer disease: 12 with an uncomplicated ulcer, 5 with perforation, the rest with ongoing bleeding. Fourteen patients had recurrent bleeding. The 5G/5G and G43A genotypes were not detected in patients with uncomplicated ulcers. All patients with ulcer perforation had the G43G genotype, 60% of patients had the 4G/4G genotype, and the rest of them had the 4G/5G and 5G/5G genotypes. The number of carriers of the 5G allele (86.05%) was higher in patients with bleeding than in ones with ulcer perforation (p=0.036) and ulcer without bleeding (p=0.021, χ2=5.32). The number of carriers of the 5G allele was higher in patients with recurrent bleeding (92.86%) than those without any relapses (82.76%) but there were no statistically significant differences (p=0.27, χ2=0.802). The G43G homozygous genotype was found in 94.12% of patients with peptic ulcer without bleeding, which was statistically significantly higher (p=0.02) than the ones with bleeding. The A allele was observed in 27.91% of patients with bleeding and 8.33% patients without any bleeding (p=0.05). The number of carriers of the A allele in patients with recurrent bleeding was statistically significantly higher than in ones without any bleeding (p=0.046). The 5G and A alleles in patients with a peptic ulcer can be used to predict the course of peptic ulcer disease and can be regarded as a predictor of the risk of bleeding relapse. |
| اللغة: | English |
| تدمد: | 1844-3117 1844-122X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031064fab120b81823836c8030f274f1Test http://europepmc.org/articles/PMC7378332Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....031064fab120b81823836c8030f274f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18443117 1844122X |
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