التفاصيل البيبلوغرافية
| العنوان: |
Association between Interleukin-19 Concentration and Degree of Severity of Acne Vulgaris. |
| المؤلفون: |
Albalat, Waleed Mohamed, Elsaid, Hanaa Hosny, Ibrahim, Hadeer Helmy |
| المصدر: |
Zagazig University Medical Journal; 2024 Supplement, Vol. 30, p232-237, 6p |
| مصطلحات موضوعية: |
ACNE, HUMAN chromosomes, GENOMICS, AGE of onset, GENE clusters |
| مستخلص: |
Background: Acne vulgaris is a multifactorial disease associated with pilosebaceous follicle and results in inflammatory and non-inflammatory lesions. Interleukin-19 was identified for the first time in 2000 by analysis of genomic sequences for IL-10 homologues, the genetic location for IL-19 on human chromosome 1q32, and is closely linked to IL-10 as part of a gene cluster with IL-20 and IL-24. The study aimed to measure serum IL-19 levels in different degrees of severity of acne vulgaris patients for better understanding of its role in the etiopathogenesis of acne, and to prove if there is a possible correlation between serum Interleukin 19 level and the degree of severity of the acne. Methods: Our study was a case control study done at out-patient clinic of Dermatology, Venereology and Andrology Department at Zagazig University Hospitals. The study included 48 individuals divided into 2 groups: Patient group: 36 patients with acne vulgaris (12 mild, 12 moderate, 12 severe) Control group: 12 healthy persons. All subjects in this study were subjected to history taking and assessment of the severity of acne using acne staging and laboratory investigation (IL-19). Results: There was statistically significant difference in serum IL-19 between the different grades of the disease severity. Analysis revealed significant difference in IL19 serum concentration between (mild and moderate group) and (moderate and severe group), While highly significant difference was found between IL-19 serum concentration of mild cases group and severe cases group. Serum IL-19 level was not statistically related to the age of onset, family history, gender, and previous treatment. Conclusions: From this study we could prove that IL-19 is related to the inflammatory etiopathogenesis of mild, moderate and severe acne vulgaris. Also, Serum IL-19 level has significant statistical difference between the different grades of acne vulgaris severity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
