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المؤلفون: Ravlo, Erlend, Ianevski, Aleksandr, Starheim, Eirin, Wang, Wei, Ji, Ping, Lysvand, Hilde, Smura, Teemu, Kivi, Gaily, Voolaid, Maia-Liisa, Plaan, Kati, Ustav, Mart, Zusinaite, Eva, Tenson, Tanel, Kurg, Reet, Oksenych, Valentyn, Walstad, Kirsti, Nordbø, Svein Arne, Kaarbø, Mari, Ernits, Karin, Bjørås, Magnar, Kainov, Denis E, Høysæter Fenstad, Mona
المصدر: International Journal of Infectious Diseases. 137:75-78
مصطلحات موضوعية: Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Immunologi inom det medicinska området, Medical and Health Sciences, Basic Medicine, Immunology in the medical area
الوصول الحر: https://lup.lub.lu.se/record/eb8c0341-cabe-4400-804f-6c10528b84b8Test
http://dx.doi.org/10.1016/j.ijid.2023.10.011Test -
2دورية أكاديمية
المؤلفون: Adnan Awad, Shady, Dufva, Olli, Klievink, Jay, Karjalainen, Ella, Ianevski, Aleksandr, Pietarinen, Paavo, Kim, Daehong, Potdar, Swapnil, Wolf, Maija, Lotfi, Kourosh, Aittokallio, Tero, Wennerberg, Krister, Porkka, Kimmo, Mustjoki, Satu
المصدر: Cell Reports Medicine ; page 101521 ; ISSN 2666-3791
الإتاحة: https://doi.org/10.1016/j.xcrm.2024.101521Test
https://api.elsevier.com/content/article/PII:S2666379124001903?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666379124001903?httpAccept=text/plainTest -
3دورية أكاديمية
المؤلفون: Ianevski, Aleksandr, Frøysa, Irene Trøen, Lysvand, Hilde, Calitz, Carlemi, Smura, Teemu, Schjelderup Nilsen, Hans-Johnny, Høyer, Erling, Afset, Jan Egil, Sridhar, Adithya, Wolthers, Katja C., Zusinaite, Eva, Tenson, Tanel, Kurg, Reet, Oksenych, Valentyn, Galabov, Angel S., Stoyanova, Adelina, Bjørås, Magnar, Kainov, Denis E.
المساهمون: Helse Midt-Norge RHF
المصدر: Antiviral Research ; volume 224, page 105842 ; ISSN 0166-3542
مصطلحات موضوعية: Virology, Pharmacology
الإتاحة: https://doi.org/10.1016/j.antiviral.2024.105842Test
https://api.elsevier.com/content/article/PII:S0166354224000500?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0166354224000500?httpAccept=text/plainTest -
4تقرير
المؤلفون: Benjakul, Sopisa, Anthi, Aina Karen, Kolderup, Anette, Vaysburd, Marina, Lode, Heidrun Elisabeth, Mallery, Donna, Fossum, Even, Vikse, Elisabeth Lea, Albecka, Anna, Ianevski, Aleksandr, Kainov, Denis, Karlsen, Karine Flem, Sakya, Siri Aastedatter, Nyquist-Andersen, Mari, Gjolberg, Torleif Tollefsrud, Moe, Morten C., Bjoras, Magnar, Sandlie, Inger, James, Leo C., Andersen, Jan Terje
المساهمون: Institute for Molecular Medicine Finland, Doctoral Programme in Integrative Life Science, Department of Computer Science, Doctoral Programme in Drug Research
مصطلحات موضوعية: Ace2, FcRn, SARS-CoV-2, Half-life, Mucosal delivery, 3111 Biomedicine
وصف الملف: application/pdf
العلاقة: This work was partially supported by the Research Council of Norway through its Centres of Excellence scheme (Project number 332727). The authors are grateful to Dr Wayne I. Lencer (Boston Children's Hospital, Harvard Medical School and Harvard Digestive Diseases Center, United States) for providing us with the HMEC-1-FcRn cell line, and Dr Alexander Haas and Dr Jens Fischer (pRED Roche Innovation Center Munich, Germany) for the MDCKII-FcRn cell line.; Benjakul , S , Anthi , A K , Kolderup , A , Vaysburd , M , Lode , H E , Mallery , D , Fossum , E , Vikse , E L , Albecka , A , Ianevski , A , Kainov , D , Karlsen , K F , Sakya , S A , Nyquist-Andersen , M , Gjolberg , T T , Moe , M C , Bjoras , M , Sandlie , I , James , L C & Andersen , J T 2023 , ' A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery ' . https://doi.org/10.1093/pnasnexus/pgad403Test; d7eb90f2-dc6d-4fdb-ba0d-e642cb6debb3; http://hdl.handle.net/10138/569342Test; 001124580500005
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5دورية أكاديمية
المؤلفون: Ianevski, Aleksandr, Simonsen, Ronja M., Myhre, Vegard, Tenson, Tanel, Oksenych, Valentyn, Bjorås, Magnar, Kainov, Denis E.
المساهمون: Institute for Molecular Medicine Finland, University of Helsinki
مصطلحات موضوعية: RESOURCE, 1182 Biochemistry, cell and molecular biology
وصف الملف: application/pdf
العلاقة: European Regional Development Fund; Mobilitas Pluss Project [MOBTT39 to D.K.]; South-Eastern Norway Regional Health Authority Open Project Fund [2021076 to M.B.]; Research Council of Norway, Large Interdisciplinary Researcher project [326101 to M.B.]. Funding for open access charge: Mobilitas Pluss Project [MOBTT39].; Ianevski , A , Simonsen , R M , Myhre , V , Tenson , T , Oksenych , V , Bjorås , M & Kainov , D E 2022 , ' DrugVirus.info 2.0 : an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs) ' , Nucleic Acids Research , vol. 50 , no. W1 , pp. W272-W275 . https://doi.org/10.1093/nar/gkac348Test; ORCID: /0000-0002-7780-482X/work/130605543; 05ea36d3-541d-42e8-9bca-34e5a6368bbd; http://hdl.handle.net/10138/355841Test; 000799563500001
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6دورية أكاديمية
المساهمون: Carugo, Oliviero, Eisenhaber, Frank, Institute for Molecular Medicine Finland, Computational Systems Medicine, Helsinki Institute for Information Technology, Tero Aittokallio / Principal Investigator, Bioinformatics
مصطلحات موضوعية: Drug combinations, High-throughput screening, Precision oncology, Predictive modeling, Synergy scoring, Toxic effects, 3111 Biomedicine
وصف الملف: application/pdf
العلاقة: The authors thank the High-Throughput Chemical Biology Screening Platform at the Centre for Molecular Medicine Norway (NCMM) for assistance with the combination screening experiments. The work was supported by the grants from Helse Sør-Øst (2020026 to TA), the Norwegian Cancer Society (216104 to TA), the Radium Hospital Foundation (TA), the Academy of Finland (310507, 313267, 326238, and 344698 to TA), the Sigrid Jusélius Foundation (TA), the Finnish Cancer Foundation (TA), and the ERANET PerMed Co-Fund (projects JAKSTAT-TARGET to TA and CLL-CLUE to TA and SS).; Data Mining Techniques for the Life Sciences; Methods in Molecular Biology; Athanasiadis , P , Ianevski , A , Skånland , S S & Aittokallio , T 2022 , Computational Pipeline for Rational Drug Combination Screening in Patient-Derived Cells . in O Carugo & F Eisenhaber (eds) , Data Mining Techniques for the Life Sciences . Methods in Molecular Biology , vol. 2449 , Humana press , New York , pp. 327-348 . https://doi.org/10.1007/978-1-0716-2095-3_14Test; ORCID: /0000-0002-0886-9769/work/130150962; ORCID: /0000-0002-7780-482X/work/130151784; 85129417015; 2059d8dd-09f8-4f0f-b7ca-984ec868b5ec; http://hdl.handle.net/10138/565416Test
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7دورية أكاديمية
المؤلفون: Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Arjama, Mariliina, Välimäki, Katja, Ianevski, Aleksandr, Ianevski, Philipp, Bergstrom, Rebecka, Dini, Alice, Kanerva, Anna, Koivisto-Korander, Riitta, Tapper, Johanna, Lassus, Heini, Loukovaara, Mikko, Mägi, Andrus, Hirasawa, Akira, Aoki, Daisuke, Pietiäinen, Vilja, Pellinen, Teijo, Butzow, Ralf, Aittokallio, Tero, Kallioniemi, Olli
المساهمون: Institute for Molecular Medicine Finland, Precision Systems Medicine, University of Helsinki, Helsinki Institute of Life Science HiLIFE, ATG - Applied Tumor Genomics, Research Programs Unit, Department of Computer Science, Computational Systems Medicine, HUS Gynecology and Obstetrics, Akseli Eetu Hemminki / Principal Investigator, Clinicum, Department of Obstetrics and Gynecology, Digital Precision Cancer Medicine (iCAN), Department of Pathology, HUSLAB, Helsinki Institute for Information Technology, Tero Aittokallio / Principal Investigator, Bioinformatics
مصطلحات موضوعية: Reprogrammed cells, Sensitivity, Resistant, 3122 Cancers
وصف الملف: application/pdf
العلاقة: Murumägi , A , Ungureanu , D , Khan , S , Arjama , M , Välimäki , K , Ianevski , A , Ianevski , P , Bergstrom , R , Dini , A , Kanerva , A , Koivisto-Korander , R , Tapper , J , Lassus , H , Loukovaara , M , Mägi , A , Hirasawa , A , Aoki , D , Pietiäinen , V , Pellinen , T , Butzow , R , Aittokallio , T & Kallioniemi , O 2023 , ' Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer : real-time therapy tailoring for a patient with low-grade serous carcinoma ' , British Journal of Cancer , vol. 128 , no. 4 , pp. 678–690 . https://doi.org/10.1038/s41416-022-02067-zTest; ORCID: /0000-0003-3125-2406/work/130599883; ORCID: /0000-0002-7797-188X/work/130600057; ORCID: /0000-0002-0886-9769/work/130604458; ORCID: /0000-0003-0598-5147/work/130604861; ORCID: /0000-0002-7780-482X/work/130605544; ORCID: /0000-0003-1627-9571/work/130605742; ORCID: /0000-0002-9314-4972/work/130606286; 82a46ff4-7660-4e79-9f40-fd864405dcb7; http://hdl.handle.net/10138/355840Test; 000894989800004
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8دورية أكاديمية
المؤلفون: Ravlo, Erlend, Ianevski, Aleksandr, Starheim, Eirin, Wang, Wei, Ji, Ping, Lysvand, Hilde, Smura, Teemu, Kivi, Gaily, Voolaid, Maia-Liisa, Plaan, Kati, Ustav, Mart, Ustav Jr, Mart, Zusinaite, Eva, Tenson, Tanel, Kurg, Reet, Oksenych, Valentyn, Walstad, Kirsti, Nordba, Svein Arne, Kaarba, Mari, Ernits, Karin, Bjaras, Magnar, Kainov, Denis E., Fenstad, Mona Haysaeter
المساهمون: Department of Virology, HUSLAB, HUS Diagnostic Center, Institute for Molecular Medicine Finland, Department of Computer Science, University of Helsinki
مصطلحات موضوعية: Covid-19, Immune response, Neutralizing antibody, SARS-CoV-2, mRNA vaccination, 3121 General medicine, internal medicine and other clinical medicine
وصف الملف: application/pdf
العلاقة: Ravlo , E , Ianevski , A , Starheim , E , Wang , W , Ji , P , Lysvand , H , Smura , T , Kivi , G , Voolaid , M-L , Plaan , K , Ustav , M , Ustav Jr , M , Zusinaite , E , Tenson , T , Kurg , R , Oksenych , V , Walstad , K , Nordba , S A , Kaarba , M , Ernits , K , Bjaras , M , Kainov , D E & Fenstad , M H 2023 , ' Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study ' , International Journal of Infectious Diseases , vol. 137 , pp. 75-78 . https://doi.org/10.1016/j.ijid.2023.10.011Test; 9b050f05-220d-4220-9fd6-8793004b5265; http://hdl.handle.net/10138/568052Test; 001104000200001
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9دورية أكاديمية
المؤلفون: Potdar, Swapnil, Ianevski, Filipp, Ianevski, Aleksandr, Tanoli, Ziaurrehman, Wennerberg, Krister, Seashore-Ludlow, Brinton, Kallioniemi, Olli, Östling, Päivi, Aittokallio, Tero, Saarela, Jani
المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Computational Systems Medicine, Divisions of Faculty of Pharmacy, Helsinki Institute for Information Technology, Tero Aittokallio / Principal Investigator, Bioinformatics, Research Programs Unit
مصطلحات موضوعية: 1182 Biochemistry, cell and molecular biology
وصف الملف: application/pdf
العلاقة: Potdar , S , Ianevski , F , Ianevski , A , Tanoli , Z , Wennerberg , K , Seashore-Ludlow , B , Kallioniemi , O , Östling , P , Aittokallio , T & Saarela , J 2023 , ' Breeze 2.0 : an interactive web-tool for visual analysis and comparison of drug response data ' , Nucleic Acids Research , vol. 51 , no. W1 , pp. W57-W61 . https://doi.org/10.1093/nar/gkad390Test; ORCID: /0000-0001-7306-7175/work/139503792; ORCID: /0000-0002-0886-9769/work/139506256; ORCID: /0000-0003-2435-9862/work/139506581; ORCID: /0000-0002-7780-482X/work/139506805; ORCID: /0000-0002-2778-6918/work/139507073; 4dfe9088-49ec-46fa-b4ec-2833910f42bb; http://hdl.handle.net/10138/563604Test; 000985764300001
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10دورية أكاديمية
المؤلفون: Wagoner, Jessica, Herring, Shawn, Hsiang, Tien-Ying, Ianevski, Aleksandr, Biering, Scott B., Xu, Shuang, Hoffmann, Markus, Poehlmann, Stefan, Gale, Michael, Aittokallio, Tero, Schiffer, Joshua T., White, Judith M., Polyak, Stephen J.
المساهمون: Helsinki Institute of Life Science HiLIFE, Joint Activities, Institute for Molecular Medicine Finland, Computational Systems Medicine, Helsinki Institute for Information Technology, Tero Aittokallio / Principal Investigator, Bioinformatics
مصطلحات موضوعية: SARS-CoV-2, coronavirus, host-targeting antiviral, HTA, directly acting antiviral, DAA, combination, synergy, molnupiravir, camostat, paxlovid, Calu-3, antiviral, drug combinations, variant(s) of concern, Ebola, ANTIRETROVIRAL THERAPY, INHIBITION, TMPRSS2, 11832 Microbiology and virology
وصف الملف: application/pdf
العلاقة: J.M.W. was partially supported by NIH grant AI114776. S.J.P. was partially supported by a Washington Research Foundation Technology Commercialization Grant and the Department of Laboratory Medicine and Pathology (University of Washington). T.A. was partially supported by Academy of Finland grants 345803 and 340141. S.B.B. was partially supported as an Open Philanthropy Awardee of the Life Sciences Research Foundation. M.G. and T.-Y.H. were supported by NIH/NIAID grant AI151698. S.P. was supported by BMBF grants (01KI2006D, 01KI20328A, and 01KX2021), by the Ministry for Science and Culture of Lower Saxony (14-76103-184, MWK HZI COVID-19), and by the German Research Foundation (DFG; PO 716/11-1 and PO 716/14-1).; Wagoner , J , Herring , S , Hsiang , T-Y , Ianevski , A , Biering , S B , Xu , S , Hoffmann , M , Poehlmann , S , Gale , M , Aittokallio , T , Schiffer , J T , White , J M & Polyak , S J 2022 , ' Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2 ' , Microbiology Spectrum , vol. 10 , no. 5 , ARTN e03331-22 . https://doi.org/10.1128/spectrum.03331-22Test; ORCID: /0000-0002-0886-9769/work/129059996; ORCID: /0000-0002-7780-482X/work/129063791; de0f82ed-4af1-4d6e-bd65-516d46ca1062; http://hdl.handle.net/10138/354520Test; 000864093700001
