المؤلفون: Henk M.W. Verheul, Danielle J. Vugts, Liangfu Chen, Adam McGeoch, Matthew Cleveland, Sean Zhang, Wasfi Al-Azzam, Deborah A. Smith, Iain McSherry, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman, Otto S. Hoekstra, I. Freedman, Mats Bergström, Chris Matheny, Guus A.M.S. van Dongen

المساهمون: CCA - Imaging and biomarkers, Medical oncology, AII - Cancer immunology, CCA - Cancer biology and immunology, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, ACS - Heart failure & arrhythmias

المصدر: Journal of Nuclear Medicine, 60(7), 902-909. Society of Nuclear Medicine Inc.
Journal of Nuclear Medicine
The Journal of Nuclear Medicine (1978), 60, 902-909
The Journal of Nuclear Medicine (1978), 60, 7, pp. 902-909
Willemien Menke-van der Houven van Oordt, C, McGeoch, A, Bergstrom, M, McSherry, I, Smith, D A, Cleveland, M, Al-Azzam, W, Chen, L, Verheul, H, Hoekstra, O S, Vugts, D J, Freedman, I, Huisman, M, Matheny, C, van Dongen, G & Zhang, S 2019, ' Immuno-PET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors ', Journal of Nuclear Medicine, vol. 60, no. 7, pp. 902-909 . https://doi.org/10.2967/jnumed.118.214726Test

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Biodistribution, Receptor, ErbB-3, medicine.drug_class, Dose-Response Relationship, Immunologic, Pharmacology, Monoclonal antibody, Antibodies, Monoclonal, Humanized, Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2], 03 medical and health sciences, Clinical, 0302 clinical medicine, HER3, antibody, Neoplasms, medicine, Distribution (pharmacology), Humans, Radiology, Nuclear Medicine and imaging, Tissue Distribution, Epidermal growth factor receptor, Receptor, Radioisotopes, dose selection, biology, business.industry, target engagement, Standard treatment, Target engagement, Middle Aged, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Positron-Emission Tomography, immuno-PET, biology.protein, Female, Zirconium, Antibody, Safety, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68275d66b8158227b35257ae3aad65e1Test
https://research.vumc.nl/en/publications/6be6979d-ecb2-4d23-9e0c-1a8d863331d4Test

المؤلفون: Lynda J. Haberer, Iain McSherry, Linda McCarthy, Anna Cargill

المصدر: European Journal of Clinical Pharmacology

مصطلحات موضوعية: Adult, Male, CYP2C8, CYP3A4, Midazolam, Drug interaction, Organic Anion Transporters, CYP2C19, Pharmacology, Cytochrome P-450 CYP2C8, Receptors, CCR, Young Adult, medicine, ATP Binding Cassette Transporter, Subfamily G, Member 2, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Pharmacology (medical), Rosuvastatin, Rosuvastatin Calcium, Omeprazole, Sulfonamides, Vercirnon, Pioglitazone, Liver-Specific Organic Anion Transporter 1, Chemistry, OATP1B1, General Medicine, Middle Aged, Clinical Trial, Neoplasm Proteins, Cytochrome P-450 CYP2C19, Fluorobenzenes, Pyrimidines, ATP-Binding Cassette Transporters, Female, Thiazolidinediones, BCRP, Aryl Hydrocarbon Hydroxylases, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aec583b5a5ec1e91d450b9bd00d22aTest
https://doi.org/10.1007/s00228-013-1592-7Test

المؤلفون: Simon J. Potocnik, Iain McSherry, Hong Ding, Timothy V. Murphy, Neela Kotecha, Kim A. Dora, Kathryn H. Yuill, Chris R. Triggle, Michael A. Hill

المصدر: Microcirculation. 16:377-390

مصطلحات موضوعية: Male, medicine.medical_specialty, Small-Conductance Calcium-Activated Potassium Channels, Physiology, Vasodilator Agents, Myogenic contraction, Muscle Proteins, Vasodilation, Apamin, Membrane Potentials, Microcirculation, Mice, chemistry.chemical_compound, Physiology (medical), Internal medicine, medicine, Animals, Vasoconstrictor Agents, Muscle, Skeletal, Molecular Biology, Mice, Inbred BALB C, Chemistry, Skeletal muscle, Anatomy, Hyperpolarization (biology), Potassium channel, Arterioles, medicine.anatomical_structure, Endocrinology, Endothelium, Vascular, medicine.symptom, Cardiology and Cardiovascular Medicine, Vasoconstriction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea5700a5a68a2176a18ce3199c5cef4Test
https://doi.org/10.1080/10739680902804042Test

المؤلفون: Hiroko Ino, Noriaki Kanemoto, Iain McSherry, Takashi Sakamoto, Toshiyasu Hirama, Lynda J. Haberer, Kimberley Hacquoil

المصدر: Clinical pharmacology in drug development. 2(4)

مصطلحات موضوعية: business.industry, medicine.drug_class, Significant difference, Cmax, Area under the curve, Pharmaceutical Science, CCR9, Pharmacology, Receptor antagonist, Crossover study, Bioavailability, Pharmacokinetics, Medicine, Pharmacology (medical), business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b4fb631bad9aa91a7b2187ca0457baTest
https://pubmed.ncbi.nlm.nih.gov/27121943Test