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Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19

التفاصيل البيبلوغرافية
العنوان: Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19
المؤلفون: Konstantinos Leventogiannis, Vasiliki Lygoura, Anastasia Michail, Anna Samakidou, Nikolaos K. Gatselis, Evangelos J. Giamarellos-Bourboulis, Stella Gabeta, Efthymia Petinaki, Marianna Vlychou, Sarah P. Georgiadou, Aggelos Stefos, George N. Dalekos, George Ntaios, George Giannoulis
المصدر: European Journal of Internal Medicine
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Male, BMI, body mass index, medicine.medical_treatment, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Intubation, 030212 general & internal medicine, Respiratory system, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2-related, COVID-19, coronavirus disease 2019, Respiratory Distress Syndrome, LDH, lactate dehydrogenase, Mortality rate, Middle Aged, Tocilizumab, IVIG, intravenous infusions of γ-globulins, Treatment Outcome, Anakinra, CRP, C-reactive protein, Female, Original Article, Respiratory Insufficiency, JAK, Janus kinase, medicine.drug, medicine.medical_specialty, Secondary infection, TNF-α, tumor necrosis factor-α, sHLH, haemophagocytic lymphohistiocytosis, 03 medical and health sciences, Internal medicine, Internal Medicine, medicine, Humans, RCTs, randomized controlled trials, Adverse effect, Aged, IL-6, SARS-CoV-2, IL-1, business.industry, COVID-19, HR, hazard ratio, IL, interleukin, MAS, macrophage activation syndrome, OR, odds ratio, Interleukin 1 Receptor Antagonist Protein, chemistry, Respiratory failure, business
الوصف: Aims Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may lead to the development of severe respiratory failure. In hospitalized-patients, prompt interruption of the virus-driven inflammatory process by using combination treatments seems theoretically of outmost importance. Our aim was to investigate the hypothesis of multifaceted management of these patients. Methods A treatment algorithm based on ferritin was applied in 311 patients (67.2% males; median age 63-years; moderate disease, n=101; severe, n=210). Patients with ferritin
تدمد: 0953-6205
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeb4d901f0603ee9f7a8f8a76a3ddcfTest
https://doi.org/10.1016/j.ejim.2021.03.026Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....9eeb4d901f0603ee9f7a8f8a76a3ddcf
قاعدة البيانات: OpenAIRE
الوصف
تدمد:09536205