Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo
| العنوان: | Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo |
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| المؤلفون: | Helen Budge, James Law, Hannah Scotney, Michael E. Symonds, Don Sharkey, Konstantinos N. Manolopoulos |
| المصدر: | Metabolism |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Brown adipose tissue, Body Temperature, AUC, area under the curve, 0302 clinical medicine, Endocrinology, Adipose Tissue, Brown, TREF, reference point temperature, DXA, dual energy x-ray absorptiometry, HOMA, homeostatic model assessment, Thermogenesis, Clinical Science, NRES, National Research Ethics Service, TSCR, supraclavicular temperature, Thermogenin, medicine.anatomical_structure, Thermography, HC, hydrocortisone, Glucocorticoid, medicine.drug, Adult, medicine.medical_specialty, ATP, adenosine triphosphate, Adolescent, 030209 endocrinology & metabolism, Biology, 18FDG-PET/CT, 18F-fluorodeoxyglucose-positron emission tomography/computed tomography, ISO, isoprenaline, IT, infrared thermography, Young Adult, 03 medical and health sciences, Double-Blind Method, In vivo, tAUC, time-averaged area under the curve, Internal medicine, Receptors, Adrenergic, beta, UCP1, uncoupling protein 1, NEFA, non-esterified fatty acids, medicine, Animals, Humans, Endocrine system, Glucocorticoids, Hydrocortisone, CRF, clinical research facility, Isoproterenol, β-AR, beta adrenoceptor, Metabolism, REC, research ethics committee, BAT, brown adipose tissue, 030104 developmental biology, NIHR, National Institute for Health Research, Infrared thermography, Beta adrenoceptor |
| الوصف: | © 2017 The Authors Introduction Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adrenoceptor (β-AR) pathway. The in vivo endocrine regulation of this pathway in humans is unknown. The objective of our study was to assess the in vivo BAT temperature responses to acute glucocorticoid administration. Methods We studied 8 healthy male volunteers, not pre-selected for BAT presence or activity and without prior BAT cold-activation, on two occasions, following an infusion with hydrocortisone (0.2 mg.kg− 1.min− 1 for 14 h) and saline, respectively. Infusions were given in a randomized double-blind order. They underwent assessment of supraclavicular BAT temperature using infrared thermography following a mixed meal, and during β-AR stimulation with isoprenaline (25 ng.kg fat-free mass− 1.min− 1 for 60 min) in the fasting state. Results During hydrocortisone infusion, BAT temperature increased both under fasting basal conditions and during β-AR stimulation. We observed a BAT temperature threshold, which was not exceeded despite maximal β-AR activation. We conclude that BAT thermogenesis is present in humans under near-normal conditions. Glucocorticoids modulate BAT function, representing important physiological endocrine regulation of body temperature at times of acute stress. |
| وصف الملف: | application/pdf; PDF |
| تدمد: | 0026-0495 1532-8600 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576a3ea2d6ce0eb57eeb1eff634c9bccTest https://doi.org/10.1016/j.metabol.2017.01.024Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....576a3ea2d6ce0eb57eeb1eff634c9bcc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00260495 15328600 |
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