دورية أكاديمية
ВЫБОР ТЕРАПИИ НИТРАТАМИ У БОЛЬНЫХ СТАБИЛЬНОЙ СТЕНОКАРДИЕЙ НАПРЯЖЕНИЯ: СРАВНИТЕЛЬНОЕ ИССЛЕДОВАНИЕ ОБЫЧНЫХ ТАБЛЕТОК ИЗОСОРБИДА ДИНИТРАТА И РАЗЛИЧНЫХ ЛЕКАРСТВЕННЫХ ФОРМ ИЗОСОРБИД-5-МОНОНИТРАТА
| العنوان: | ВЫБОР ТЕРАПИИ НИТРАТАМИ У БОЛЬНЫХ СТАБИЛЬНОЙ СТЕНОКАРДИЕЙ НАПРЯЖЕНИЯ: СРАВНИТЕЛЬНОЕ ИССЛЕДОВАНИЕ ОБЫЧНЫХ ТАБЛЕТОК ИЗОСОРБИДА ДИНИТРАТА И РАЗЛИЧНЫХ ЛЕКАРСТВЕННЫХ ФОРМ ИЗОСОРБИД-5-МОНОНИТРАТА |
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| المؤلفون: | Egorov, V., Shilova, E., Martsevich, S. |
| بيانات النشر: | Общество с ограниченной ответственностью «Столичная издательская компания» |
| سنة النشر: | 2008 |
| المجموعة: | CyberLeninka (Scientific Electronic Library) / Научная электронная библиотека «Киберленинка» |
| مصطلحات موضوعية: | СТАБИЛЬНАЯ СТЕНОКАРДИЯ, ИЗОСОРБИДА ДИНИТРАТ, ИЗОСОРБИД-5-МОНОНИТРАТ, ISOSORBIDE-5-MONONITRATE. RATIONAL PHARMACOTHER |
| الوصف: | Aim. To study efficacy and tolerability of isosorbide-5-mononitrate (IMN) in various presentations in comparison with isosorbide dinitrate (IDN) in usual tablets in patients with stable angina. Material and Methods. 22 patients (5 women and 17 men) with stable angina of II-III functional class were involved into open randomized comparative crossover study. Patients were splitin 3groups and received each of studied drugs during 4 weeks. IDN (Nitrosorbide, Nizpharm, Russia) in usual tablets10 mg prescribed for 3 times a day administration; IMN (Monocinque,Berlin-Chemie, German) in tablets 20 mg prescribed for 2 times a day administration. After 1 week therapy the doses of IDN or IMN doubled if it was clinically necessary. Retarded presentation of IMN (Monocinque Retard, Berlin-Chemie, German) in capsules 50 mg prescribed once daily. Drug efficacy was evaluated by changes in clinical symptoms, number of angina attacks, demand in short-acting sublingual nitroglycerin as well as physical activity tolerance. Results. After4 weeks18patients completed study, 2patients dropped out becauseofprotocol nonobservance and2patients dropped out becauseofside effects (headache). IDN therapy in adjusted dose provided antianginal effect in 15 (83,3%) patients: a number of angina attacks decreased in 39,6%, short-acting nitroglycerin demand reduced in 47,7%. Monocinque in adjusted dose provided antianginal effect in 16 (88,9%) patients: a number of angina attacks decreased in 60%, short-acting nitroglycerin demand reduced in 63%. Monocinque Retard provided good antianginal effect in 18 (100%) patients: a number of angina attacks decreased in 72%, short-acting nitroglycerin demand reduced in 84,8%. There were not significant differences in frequency and severity of headache between studied drugs. Conclusion. IMN therapy with both presentations (administrated 1 or 2 times a day) was more convenient and effective than IDN (administrated 3 times a day). |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | unknown |
| الإتاحة: | http://cyberleninka.ru/article/n/vybor-terapii-nitratami-u-bolnyh-stabilnoy-stenokardiey-napryazheniya-sravnitelnoe-issledovanie-obychnyh-tabletok-izosorbidaTest http://cyberleninka.ru/article_covers/9415836.pngTest |
| رقم الانضمام: | edsbas.9E51C619 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |