المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/journal_contribution/S1_Raw_images_-/24887834Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.s003Test
https://figshare.com/articles/journal_contribution/S1_Raw_images_-/24887834Test

المؤلفون: Vakkilainen, Svetlana, Skoog, Tiina, Einarsdottir, Elisabet, Middleton, Anna, Pekkinen, Minna, Öhman, Tiina, Katayama, Shintaro, Krjutškov, Kaarel, Kovanen, Panu E., Varjosalo, Markku, Lindqvist, Arne, Kere, Juha, Mäkitie, Outi

المساهمون: HUS Children and Adolescents, Children's Hospital, University of Helsinki, Research Programme of Molecular Medicine, Päivi Marjaana Saavalainen / Principal Investigator, Research Programs Unit, Clinicum, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Medicum, HUSLAB, Molecular Systems Biology, STEMM - Stem Cells and Metabolism Research Program, Juha Kere / Principal Investigator, Lastentautien yksikkö

مصطلحات موضوعية: 1184 Genetics, developmental biology, physiology, CARTILAGE-HAIR HYPOPLASIA, LYMPHOCYTE DYSFUNCTION, INCREASED APOPTOSIS, MOLECULAR-BASIS, T-LYMPHOCYTES, EXPRESSION, MUTATIONS, TRANSCRIPTOME, REVEALS, DEFECT

وصف الملف: application/pdf

العلاقة: Vakkilainen , S , Skoog , T , Einarsdottir , E , Middleton , A , Pekkinen , M , Öhman , T , Katayama , S , Krjutškov , K , Kovanen , P E , Varjosalo , M , Lindqvist , A , Kere , J & Mäkitie , O 2019 , ' The human long non-coding RNA gene RMRP has pleiotropic effects and regulates cell-cycle progression at G2 ' , Scientific Reports , vol. 9 , no. 1 , 13758 . https://doi.org/10.1038/s41598-019-50334-6Test; RIS: urn:D9DF1CCEEB50F07347797119C7FC1D6D; RIS: Vakkilainen2019; ORCID: /0000-0001-6647-8873/work/63999380; ORCID: /0000-0002-1340-9732/work/64000610; ORCID: /0000-0002-4573-3297/work/67134146; ORCID: /0000-0002-4547-001X/work/155651923; http://hdl.handle.net/10138/306670Test; b7678bfa-876c-4832-9445-3e69afc6ff50; 000487365300033

الإتاحة: http://hdl.handle.net/10138/306670Test

المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/figure/Influence_of_ionizing_radiation_on_the_activity_of_Atox1_at_different_status_WT_and_KO_of_the_TP53_gene_in_A549_and_HCT116_cell_lines_24h_after_ionizing_irradiation_10Gy_exposure_/24887828Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.s001Test
https://figshare.com/articles/figure/Influence_of_ionizing_radiation_on_the_activity_of_Atox1_at_different_status_WT_and_KO_of_the_TP53_gene_in_A549_and_HCT116_cell_lines_24h_after_ionizing_irradiation_10Gy_exposure_/24887828Test

المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/figure/Analyzing_the_effect_of_ATOX1_and_TP53_gene_siRNA-mediated_knockdown_on_mutual_expression_HCT116_cell_line_/24887831Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.s002Test
https://figshare.com/articles/figure/Analyzing_the_effect_of_ATOX1_and_TP53_gene_siRNA-mediated_knockdown_on_mutual_expression_HCT116_cell_line_/24887831Test

المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/figure/Influence_of_cytotoxic_agents_on_the_activity_of_Atox1_at_different_status_WT_and_KO_of_the_i_TP53_i_gene_in_A549_and_HCT116_cell_lines_24h_after_drugs_exposure_/24887840Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.g002Test
https://figshare.com/articles/figure/Influence_of_cytotoxic_agents_on_the_activity_of_Atox1_at_different_status_WT_and_KO_of_the_i_TP53_i_gene_in_A549_and_HCT116_cell_lines_24h_after_drugs_exposure_/24887840Test

المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/figure/The_effect_of_cytostatic_agents_on_the_intracellular_localization_of_the_Atox1_protein_at_different_statuses_WT_and_KO_of_the_TP53_gene_in_the_A549_24_hours_after_drugs_exposure_/24887843Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.g003Test
https://figshare.com/articles/figure/The_effect_of_cytostatic_agents_on_the_intracellular_localization_of_the_Atox1_protein_at_different_statuses_WT_and_KO_of_the_TP53_gene_in_the_A549_24_hours_after_drugs_exposure_/24887843Test

المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/figure/Dependence_of_Atox1_and_p53_levels_in_HCT116_and_A549_cell_lines_with_different_TP53_status_/24887837Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.g001Test
https://figshare.com/articles/figure/Dependence_of_Atox1_and_p53_levels_in_HCT116_and_A549_cell_lines_with_different_TP53_status_/24887837Test

المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/figure/Hypothetical_concept_of_Atox1-mediated_cell_cycle_regulation_via_cyclin_D1_and_p53_influence_on_the_process_under_genotoxic_stress_/24887855Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.g007Test
https://figshare.com/articles/figure/Hypothetical_concept_of_Atox1-mediated_cell_cycle_regulation_via_cyclin_D1_and_p53_influence_on_the_process_under_genotoxic_stress_/24887855Test

المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/dataset/List_of_PCR_primers_/24887858Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.t001Test
https://figshare.com/articles/dataset/List_of_PCR_primers_/24887858Test

المؤلفون: Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchur

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, potential therapeutic applications, regulating cell survival, cell signaling pathways, a549 cell lines, significantly higher levels, combined antitumor therapy, particularly copper since, tumor cell survival, atox1 may act, atox1 expression decreased, promote dna repair, moderate genotoxic stress, increased p53 activity, genes increased apoptosis, div >< p, atox1 copper chaperon, genotoxic stress, cell cycle, translational levels, metallochaperone atox1, inhibiting atox1, atox1 <, wild type

العلاقة: https://figshare.com/articles/figure/Analyzing_the_effect_of_i_ATOX1_i_and_i_TP53_i_gene_siRNA-mediated_knockdown_on_mutual_expression_A549_cell_line_/24887849Test

الإتاحة: https://doi.org/10.1371/journal.pone.0295944.g005Test
https://figshare.com/articles/figure/Analyzing_the_effect_of_i_ATOX1_i_and_i_TP53_i_gene_siRNA-mediated_knockdown_on_mutual_expression_A549_cell_line_/24887849Test