Involvement of INF-γ functional single nucleotide polymorphism +874 T/A (rs2430561) in breast cancer risk
| العنوان: | Involvement of INF-γ functional single nucleotide polymorphism +874 T/A (rs2430561) in breast cancer risk |
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| المؤلفون: | Hanan E. Al-Rashidi, Dalia T Hussein, Sherif Refaat, Enas Ahmed, Fatma M. El-Tantawy, Sahar Hamed |
| المصدر: | Saudi Journal of Biological Sciences Saudi Journal of Biological Sciences, Vol 28, Iss 11, Pp 6289-6296 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, ARMS-PCR, amplification refractory mutation system, polymerase chain reaction method, ER, estrogen receptor, BC, Breast cancer, medicine.disease_cause, 01 natural sciences, Gastroenterology, TNF-α, tumor necrosis factor-α, Breast cancer, Polymorphism (computer science), Genotype, HER2, human epidermal growth factor receptor 2, Biology (General), INF-γ, CI, 95% confidence intervals, PPI, poor prognostic index, C, controls, PAM50, Prediction Analysis of Microarray 50, Original Article, ICB, inflamed cells of breast, General Agricultural and Biological Sciences, INF-γ, Interferon-γ, TNBC, Triple Negative BC, medicine.medical_specialty, IRB, Institutional Review Board, QH301-705.5, Genotypes, CD, cluster of differentiation, Single-nucleotide polymorphism, NPI, the mandatory prognostic index, NK, natural killer cells, 03 medical and health sciences, Internal medicine, TGF-β, transforming growth factor-β, medicine, Allele, Polymorphism, GPI, good prognostic index, business.industry, Cancer, PR, progesterone receptor, medicine.disease, IL, interleukin, OR, odds ratio, 030104 developmental biology, SNPs, single nucleotide polymorphism, ISGs, INF-stimulated genes, MPI, moderate prognostic index, Gene polymorphism, Risk factor, Carcinogenesis, business, Th1, T helper1, 010606 plant biology & botany |
| الوصف: | According Global Cancer Statistics 2020 GLOBOCAN estimates female breast cancer was found as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), and the fourth leading cause (6.9%) of cancer death among women worldwide. Identification of new diagnostic marker sharply characterize the tumor feature is intensive need. The present work was performed to investigate the involvement of the INF-γ + 874 T/A gene polymorphism in different breast cancer prognostic factors. Polymorphism detection analysis was performed on 163 subjects from breast cancer patients, 79 with inflamed cells of breast patients and 144 controls. The gene polymorphism was detected using the amplification refractory mutation system- polymerase chain reaction method (ARMS-PCR). The distribution of INF-γ T + 874A gene polymorphism shows strong significant association between INF-γ + 874 T/A genotypes TT in BC patients (ORTT: 6.41 [95% CI = 2.72–15.1] P |
| اللغة: | English |
| تدمد: | 2213-7106 1319-562X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb25f5926719ed18f82fc75955e0093dTest http://europepmc.org/articles/PMC8568710Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bb25f5926719ed18f82fc75955e0093d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22137106 1319562X |
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