التفاصيل البيبلوغرافية
| العنوان: |
Prognostic histological markers in oral tongue squamous cell carcinoma patients treated with (chemo)radiotherapy |
| المؤلفون: |
Hyytiainen, Aini, Mroueh, Rayan, Peltonen, Johanna, Wennerstrand, Pia, Mäkitie, Antti, Al-Samadi, Ahmed, Ventelä, Sami, Salo, Tuula |
| المساهمون: |
Research Programs Unit, Department of Oral and Maxillofacial Diseases, TRIMM - Translational Immunology Research Program, HUS Head and Neck Center, Clinicum, Korva-, nenä- ja kurkkutautien klinikka, Research Program in Systems Oncology, HUSLAB |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Oral cancer, Chemoresistance, High-endothelial venules, Hypoxia-inducible factor-1 alpha, Octamer-binding transcription factor 4, Prognostic marker, Radioresistance, 3111 Biomedicine, 11832 Microbiology and virology |
| الوصف: |
Treatment of oral tongue squamous cell carcinoma (OTSCC) frequently includes surgery with postoperative radiotherapy (RT) or chemoradiotherapy (CRT). Resistance to RT or CRT remains a major clinical challenge and highlights the need to identify predictive markers for it. We included 71 OTSCC patients treated with surgery combined with RT or CRT. We evaluated the association between tumor budding, tumor-stroma ratio (TSR), depth of invasion (DOI), tumor-infiltrating lymphocytes (TILs), hypoxia-inducible factor-1alpha (HIF-1alpha) expression, octamer-binding transcription factor 4 (OCT4) expression, high-endothelial venules (HEVs), and disease-free survival (DFS) using uni- and multivariate analyses. No significant association was observed between the different histological and molecular markers (TSR, DOI, TILs, HEV, HIF-1alph, OCT4) and DFS. However, an associative trend between DOI, budding, and DFS was noted. Further studies with larger cohorts are needed to explore the prognostic value of DOI and budding for OTSCC patients treated with postoperative RT or CRT. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Hyytiainen , A , Mroueh , R , Peltonen , J , Wennerstrand , P , Mäkitie , A , Al-Samadi , A , Ventelä , S & Salo , T 2023 , ' Prognostic histological markers in oral tongue squamous cell carcinoma patients treated with (chemo)radiotherapy ' , APMIS , vol. 131 , no. 4 , pp. 142-151 . https://doi.org/10.1111/apm.13298Test; ORCID: /0000-0001-6039-0088/work/131540867; a0558ff9-f59a-46c2-90da-026a1322226e; http://hdl.handle.net/10138/570154Test; 000930530300001 |
| الإتاحة: |
http://hdl.handle.net/10138/570154Test |
| حقوق: |
unspecified ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.F3DDBA65 |
| قاعدة البيانات: |
BASE |
