المؤلفون: Krogvold, Lars, Mynarek, Ida Maria, Ponzi, Erica, Mork, Freja Barrett, Hessel, Trine Witzner, Roald, Trine, Lindblom, Nina, Westman, Jacob, Barker, Peter, Hyoety, Heikki, Ludvigsson, Johnny, Hanssen, Kristian F., Johannesen, Jesper, Dahl-Jorgensen, Knut

المصدر: Nature Medicine. 29:2902-2908

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198659Test
https://doi.org/10.1038/s41591-023-02576-1Test
https://liu.diva-portal.org/smash/get/diva2:1806609/FULLTEXT01.pdfTest

المؤلفون: HEDIMED Investigator group, Hakola, Leena, Lund-Blix, Nicolai A., Takkinen, Hanna Mari, Tapanainen, Heli, Niinistö, Sari, Korhonen, Tuuli E., Stene, Lars C., Hyöty, Heikki, Toppari, Jorma, Ilonen, Jorma, Knip, Mikael, Veijola, Riitta, Virtanen, Suvi M., Anna, Eurén, Heikki, Hyöty, Kalle, Kurppa, Jutta, Laiho, Olli, Laitinen, Jussi, Lehtonen, Katri, Lindfors, Maria, Lönnrot, Johannes, Malkamäki, Noora, Nurminen, Matti, Nykter, Sami, Oikarinen, Leena, Puustinen, Amirbabak, Sioofy Khojine, Keijo, Viiri, Daniel, Agardh, Andrén, Aronsson Carin, Markus, Lundgren, Iida, Mäkelä, Martin, Romantschuk, Laura, Soininen, Nicolai A, Lund Blix, Maria, Magnus, Aino-Kaisa, Rantala, Lars, Stene, Ketil, Størdal, German, Tapia, Laura, Elo, Sini, Junttila, Riitta, Lahesmaa, Johanna, Lempainen, Robert, Moulder, Omid, Rasool, Tomi, Suomi, Jorma, Toppari, Ubaid, Ullah, Riitta, Veijola

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents

مصطلحات موضوعية: Cohort study, Diabetes mellitus, Type 1, Dietary intake, Gluten, Pregnancy, Prenatal exposure delayed effects, Gynaecology and paediatrics, 3143 Nutrition

وصف الملف: application/pdf

العلاقة: Supported by the Research Council of Finland (grants 63 672, 68 292, 79 685, 79 686, 80 846, 114 666, 126 813, 129 492, 139 391, 201 988, 210 632, 250 114, 276 475, 308 066, 339 922); European Foundation for the Study of Diabetes award supported by EFSD/JDRF/Lilly; the Diabetes Research Foundation; the Juho Vainio Foundation; Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital (grants 9E082, 9F089, 9G087, 9H092, 9J147, 9K149, 9L042, 9L117, 9M036, 9M114, 9N086, 9P057, 9R055, 9S074, 9T072, 9U065, 9V072, 9X062, 9AA084, 9AB083); the Juvenile Diabetes Research Foundation (grants 4-1998-274, 4-1999-731, 4-2001-435, 1-SRA-2016-342-M-R, 1-SRA-2019-732-M-B, and 3-SRA-2020-955-S-B); the Novo Nordisk Foundation; the European Union Biomed 2 Program (BMH4-CT98-3314). This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 874864 HEDIMED.; HEDIMED Investigator group , Hakola , L , Lund-Blix , N A , Takkinen , H M , Tapanainen , H , Niinistö , S , Korhonen , T E , Stene , L C , Hyöty , H , Toppari , J , Ilonen , J , Knip , M , Veijola , R , Virtanen , S M , Anna , E , Heikki , H , Kalle , K , Jutta , L , Olli , L , Jussi , L , Katri , L , Maria , L , Johannes , M , Noora , N , Matti , N , Sami , O , Leena , P , Amirbabak , S K , Keijo , V , Daniel , A , Andrén , A C , Markus , L , Iida , M , Martin , R , Laura , S , Nicolai A , L B , Maria , M , Aino-Kaisa , R , Lars , S , Ketil , S , German , T , Laura , E , Sini , J , Riitta , L , Johanna , L , Robert , M , Omid , R , Tomi , S , Jorma , T , Ubaid , U & Riitta , V 2024 , ' Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child ' , Clinical nutrition espen , vol. 62 , pp. 22-27 . https://doi.org/10.1016/j.clnesp.2024.05.001Test; http://hdl.handle.net/10138/575899Test; 496d44fc-88e5-4b28-96f5-13623a043574; 85192760911

الإتاحة: http://hdl.handle.net/10138/575899Test

المؤلفون: Hyöty, Heikki, Kääriäinen, Susanna, Laiho, Jutta E., Comer, Gail M., Tian, Wei, Härkönen, Taina, Lehtonen, Jussi P., Oikarinen, Sami, Puustinen, Leena, Snyder, Michele, León, Francisco, Scheinin, Mika, Knip, Mikael, Sanjuan, Miguel

المساهمون: Tampere University, Biosciences, LAST, Paediatrics, Department of Clinical Microbiology, Laboratory Services

مصطلحات موضوعية: 3121 Internal medicine

وصف الملف: fulltext

العلاقة: 67; ORCID: /0000-0002-6677-8654/work/157764125; https://trepo.tuni.fi/handle/10024/156237Test; URN:NBN:fi:tuni-202404163604

الإتاحة: https://doi.org/10.1007/s00125-024-06092-wTest
https://trepo.tuni.fi/handle/10024/156237Test

المؤلفون: Saarenpää, Mika, Roslund, Marja I., Nurminen, Noora, Puhakka, Riikka, Kummola, Laura, Laitinen, Olli H., Hyöty, Heikki, Sinkkonen, Aki

المساهمون: Tampere University, Biotieteet

مصطلحات موضوعية: 3111 Biomedicine

وصف الملف: fulltext

العلاقة: 108705; 187; ORCID: /0000-0003-3285-3668/work/158518502; https://trepo.tuni.fi/handle/10024/157618Test; URN:NBN:fi:tuni-202405075497

الإتاحة: https://doi.org/10.1016/j.envint.2024.108705Test
https://trepo.tuni.fi/handle/10024/157618Test

المؤلفون: Laajala, Mira, Zwaagstra, Marleen, Martikainen, Mari, Nekoua, Magloire Pandoua, Benkahla, Mehdi, Sane, Famara, Gervais, Emily, Campagnola, Grace, Honkimaa, Anni, Sioofy-Khojine, Amir-Babak, Hyöty, Heikki, Ojha, Ravi, Bailliot, Marie, Balistreri, Giuseppe, Peersen, Olve, Hober, Didier, van Kuppeveld, Frank, Marjomäki, Varpu

المساهمون: Department of Virology, Helsinki Institute of Sustainability Science (HELSUS)

مصطلحات موضوعية: Acute infection, Antiviral, Chronic infection, Drug repurposing, Enterovirus, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: This work was supported by FiDiPro and the Jane & Aatos and Erkko Foundation (M.L. and V.M.). Parts of this project were supported by the University of Helsinki Doctoral Program in Microbiology and Biotechnology (R.O.) and the Academy of Finland Research Grant 318434 (G.B. and R.O.) and NIH grant R01 AI059130 (O.P.).& nbsp; Laajala , M , Zwaagstra , M , Martikainen , M , Nekoua , M P , Benkahla , M , Sane , F , Gervais , E , Campagnola , G , Honkimaa , A , Sioofy-Khojine , A-B , Hyöty , H , Ojha , R , Bailliot , M , Balistreri , G , Peersen , O , Hober , D , van Kuppeveld , F & Marjomäki , V 2023 , ' Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type III β ' , Microbiology Spectrum , vol. 11 , no. 4 . https://doi.org/10.1128/spectrum.00552-23Test; 85168256092; dd53bbee-818e-42c4-81de-d38a13427dd1; http://hdl.handle.net/10138/570987Test; 001026451700001

الإتاحة: http://hdl.handle.net/10138/570987Test

المؤلفون: The TEDDY Study Group, Af Segerstad, Elin M. Hard, Liu, Xiang, Uusitalo, Ulla, Toppari, Jorma, Simell, Olli G., Aaltonen, Sanna-Mari, Adamsson, Annika, Ahonen, Suvi, Åkerlund, Mari, Hakola, Leena, Hekkala, Anne, Holappa, Henna, Hyöty, Heikki, Ikonen, Anni, Ilonen, Jorma, Jokipuu, Sanna, Kähönen, Miia, Karlsson, Leena, Kero, Jukka, Knip, Mikael, Koivikko, Minna-Liisa, Kokkonen, Katja, Koreasalo, Mirva, Koskenniemi, Jaakko J., Koskinen, Merja, Kurppa, Kalle, Kuusela, Salla

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents

مصطلحات موضوعية: Hla, Teddy, Celiac disease, Children, Gluten foods, 3143 Nutrition

وصف الملف: application/pdf

العلاقة: Supported in part by NIH/National Center forAdvancing Translational Sciences (NCATS) Clinical and Translational Science Awards UL1 TR000064 (to the University of Florida) and UL1 TR002535 (to the University of Colorado). The TEDDY Study is funded by grants U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, U01 DK124166, and U01 DK128847 and contract no. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases, EuniceKennedy ShriverNational Institute of Child Health and Human Development, National Institute of Environmental Health Sciences, CDC, and JDRF. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.; The TEDDY Study Group , Af Segerstad , E M H , Liu , X , Uusitalo , U , Toppari , J , Simell , O G , Aaltonen , S-M , Adamsson , A , Ahonen , S , Åkerlund , M , Hakola , L , Hekkala , A , Holappa , H , Hyöty , H , Ikonen , A , Ilonen , J , Jokipuu , S , Kähönen , M , Karlsson , L , Kero , J , Knip , M , Koivikko , M-L , Kokkonen , K , Koreasalo , M , Koskenniemi , J J , Koskinen , M , Kurppa , K & Kuusela , S 2022 , ' Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children : The Environmental Determinants of Diabetes in the Young (TEDDY) study ' , American Journal of Clinical Nutrition , vol. 116 , no. 2 , pp. 394-403 . https://doi.org/10.1093/ajcn/nqac086Test; 4f38116e-5ceb-432d-a98c-ad33b3fa5e2f; http://hdl.handle.net/10138/570135Test; 000796675300001

الإتاحة: http://hdl.handle.net/10138/570135Test

المؤلفون: Hirvonen, M. Karoliina, Lietzén, Niina, Moulder, Robert, Bhosale, Santosh D., Koskenniemi, Jaakko, Vähä-Mäkilä, Mari, Nurmio, Mirja, Orešič, Matej, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyöty, Heikki, Lähdesmäki, Harri, Knip, Mikael, Cheng, Lu, Lahesmaa, Riitta

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital

مصطلحات موضوعية: Gynaecology and paediatrics

وصف الملف: application/pdf

العلاقة: The authors are grateful to the DIPP families for their participation and the clinical personnel for excellent collaboration, working with the families and obtaining the samples and clinical data for the study. We also thank the staff of the DIPP Immunogenetics laboratory at University of Turku and the DIPP autoantibody laboratory at University of Oulu. The mass spectrometry analyses presented in this work were performed at the Proteomics Core Facility of the Turku Bioscience Centre that belongs to Biocenter Finland infrastructure network. We thank Pekka Haapaniemi (Proteomics Facility, Turku Bioscience Centre, Finland) for his invaluable help in sample preparation, and also other facility members for the excellent technical support. L. C. and H. L. acknowledges the computational resources provided by the Aalto Science-IT project and CSC—IT Center for Science, Finland. Figure was created with Biorender.com. The authors are grateful to the DIPP families for their participation and the clinical personnel for excellent collaboration, working with the families and obtaining the samples and clinical data for the study. We also thank the staff of the DIPP Immunogenetics laboratory at University of Turku and the DIPP autoantibody laboratory at University of Oulu. The mass spectrometry analyses presented in this work were performed at the Proteomics Core Facility of the Turku Bioscience Centre that belongs to Biocenter Finland infrastructure network. We thank Pekka Haapaniemi (Proteomics Facility, Turku Bioscience Centre, Finland) for his invaluable help in sample preparation, and also other facility members for the excellent technical support. L. C. and H. L. acknowledges the computational resources provided by the Aalto Science-IT project and CSC—IT Center for Science, Finland. Figure 1 was created with Biorender.com.; Hirvonen , M K , Lietzén , N , Moulder , R , Bhosale , S D , Koskenniemi , J , Vähä-Mäkilä , M , Nurmio , M , Orešič , M , Ilonen , J , Toppari , J , Veijola , R , Hyöty , H , Lähdesmäki , H , Knip , M , Cheng , L & Lahesmaa , R 2023 , ' Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes ' , Scientific Reports , vol. 13 , no. 1 , 15941 . https://doi.org/10.1038/s41598-023-43039-4Test; http://hdl.handle.net/10138/569639Test; f7c92475-6b63-441d-90c6-f70646434629; 85171842365

الإتاحة: http://hdl.handle.net/10138/569639Test

المؤلفون: Vatanen, Tommi, Jabbar, Karolina S., Ruohtula, Terhi, Honkanen, Jarno, Avila-Pacheco, Julian, Siljander, Heli, Stražar, Martin, Oikarinen, Sami, Hyöty, Heikki, Ilonen, Jorma, Mitchell, Caroline M., Yassour, Moran, Virtanen, Suvi M., Clish, Clary B., Plichta, Damian R., Vlamakis, Hera, Knip, Mikael, Xavier, Ramnik J.

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, Faculty Common Matters (Faculty of Medicine), University of Helsinki, Children's Hospital, Helsinki University Hospital Area, HUS Children and Adolescents, Clinicum

مصطلحات موضوعية: gut metabolome, horizontal gene transfer, infant gut microbiome, mother-to-infant microbiome transmission, 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health ( P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation ( 2-SRA-2016-247-S-B ), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. We thank Tiffany Poon, Luke Besse, and Timothy Arthur for sample and data management and Theresa Reimels for editorial assistance and figure preparation. This work was funded by the National Institutes of Health (P30 DK043351 to R.J.X.), Juvenile Diabetes Research Foundation (2-SRA-2016-247-S-B), Center for Microbiome Informatics and Therapeutics, and Wallenberg Foundations (to K.S.J.). M.Y. is the Rosalind, Paul and Robin Berlin Faculty Development Chair in Perinatal Research. T.V. H.V. M.K. and R.J.X. served as principal investigators. T.V. and K.S.J. analyzed metagenomic data. T.V. K.S.J. J.A.-P. M.S. C.B.C. and D.R.P. analyzed metabolomic data. T.R. analyzed intestinal biomarkers. J.H. analyzed cytokines. T.R. J.H. H.S. S.O. H.H. J.I. S.M.V. and M.K. contributed to collection of stool and blood samples and patient information. M.Y. and C.M.M. collected breast milk samples. T.V. K.S.J. D.R.P. H.V. and R.J.X. drafted the manuscript. All authors discussed the results, critically reviewed the text, and approved the final manuscript. R.J.X. is co-founder of Jnana Therapeutics and Celsius Therapeutics, board director at MoonLake Immunotherapeutics, and consultant to Nestlé; these organizations had no role in the study.; Vatanen , T , Jabbar , K S , Ruohtula , T , Honkanen , J , Avila-Pacheco , J , Siljander , H , Stražar , M , Oikarinen , S , Hyöty , H , Ilonen , J , Mitchell , C M , Yassour , M , Virtanen , S M , Clish , C B , Plichta , D R , Vlamakis , H , Knip , M & Xavier , R J 2022 , ' Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism ' , Cell , vol. 185 , no. 26 , pp. 4921-4936.e15 . https://doi.org/10.1016/j.cell.2022.11.023Test , https://doi.org/10.1016/j.cell.2022.11.023Test; ORCID: /0000-0002-2779-3384/work/128032679; ORCID: /0000-0003-0949-1291/work/128033162; 85144246023; b361273f-28e6-4eab-a116-e5c6f415caea; http://hdl.handle.net/10138/569828Test; 000910695500001

الإتاحة: http://hdl.handle.net/10138/569828Test

المؤلفون: Meinhardt, Andrea, Reilly, Liam, Kaliakatsos, Marios, Abdel-Aziz, Khaled, Alsharidah, Sondus, Bodi, Istvan, Booth, Claire, Chetty, Kritika, Evans, Jennifer, Ferreras-Antolín, Laura, Froude, Susannah, Galtrey, Clare M., Guruprasad, Suba, Hadden, Robert D., Hassell, Jane, Hyöty, Heikki, Kreins, Alexandra Y., Laiho, Jutta E., Lowe, David M., Lunn, Michael P., Mankad, Kshitij, Struik, Siske, Whittaker, Elizabeth, Worth, Austen, Yong, Patrick, Zhang, Liqun, Breuer, Judith, Kadambari, Seilesh

المصدر: Journal of Infection ; volume 88, issue 5, page 106142 ; ISSN 0163-4453

مصطلحات موضوعية: Infectious Diseases, Microbiology (medical)

الإتاحة: https://doi.org/10.1016/j.jinf.2024.106142Test
https://api.elsevier.com/content/article/PII:S0163445324000768?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0163445324000768?httpAccept=text/plainTest

المؤلفون: Laajala, Mira, Zwaagstra, Marleen, Martikainen, Mari, Nekoua, Magloire Pandoua, Benkahla, Mehdi, Sane, Famara, Gervais, Emily, Campagnola, Grace, Honkimaa, Anni, Sioofy-Khojine, Amir-Babak, Hyöty, Heikki, Ojha, Ravi, Bailliot, Marie, Balistreri, Giuseppe, Peersen, Olve, Hober, Didier, Van Kuppeveld, Frank, Marjomäki, Varpu

المساهمون: Virologie

مصطلحات موضوعية: acute infection, antiviral, chronic infection, drug repurposing, enterovirus, Microbiology (medical), Infectious Diseases, Genetics, General Immunology and Microbiology, Physiology, Cell Biology, Ecology

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/430524Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/430524Test