المؤلفون: Jiyung Shin, Ming He, Yufei Liu, Silvana Paredes, Lidia Villanova, Katharine Brown, Xiaolei Qiu, Noushin Nabavi, Mary Mohrin, Kathleen Wojnoonski, Patrick Li, Hwei-Ling Cheng, Andrew J. Murphy, David M. Valenzuela, Hanzhi Luo, Pankaj Kapahi, Ronald Krauss, Raul Mostoslavsky, George D. Yancopoulos, Frederick W. Alt, Katrin F. Chua, Danica Chen

المصدر: Cell Reports, Vol 5, Iss 3, Pp 654-665 (2013)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2211124713005767Test; https://doaj.org/toc/2211-1247Test

الوصول الحر: https://doaj.org/article/998f1e97082c46e383fcf42ca235d917Test

المؤلفون: Hwei-Ling Cheng, Mengting Qiu, Frederick W. Alt, Yiwei Chen, Elizabeth Cantor, Mai Dao, Michael T. Kimble, Ming Tian, Peyton Waddicor, Kelly McGovern, Marie-Elen Tuchel

المصدر: Proc Natl Acad Sci U S A

مصطلحات موضوعية: 0301 basic medicine, Surface Immunoglobulin, T cell, Antibody Affinity, Receptors, Antigen, B-Cell, Somatic hypermutation, Immunoglobulin light chain, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, medicine, Animals, Multidisciplinary, biology, Germinal center, Biological Sciences, Primary and secondary antibodies, V(D)J Recombination, Cell biology, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Humanized mouse, biology.protein, Immunoglobulin Light Chains, Somatic Hypermutation, Immunoglobulin, Antibody, Immunoglobulin Heavy Chains

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060d4c8c876f7fb18b2721d78834a93bTest
https://doi.org/10.1101/2020.12.12.421834Test

المؤلفون: Kelly McGovern, Nicole Manfredonia, Rachael Judson, Hwei-Ling Cheng, Mai Dao, Michael T. Kimble, Peyton Waddicor, Ming Tian, Elizabeth Cantor, Barton F. Haynes, Derek W. Cain, Lisa Rieble, Yiwei Chen, Aimee Chapdelaine-Williams, Frederick W. Alt

المصدر: Proc Natl Acad Sci U S A

مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Central B cell deletion, HIV Infections, HIV Antibodies, Immunoglobulin light chain, Lymphocyte Activation, Affinity maturation, 03 medical and health sciences, Negative selection, Mice, 0302 clinical medicine, HIV Seropositivity, medicine, Animals, Humans, Progenitor cell, B cell, AIDS Vaccines, B-Lymphocytes, Multidisciplinary, biology, env Gene Products, Human Immunodeficiency Virus, Biological Sciences, Virology, Antibodies, Neutralizing, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, biology.protein, HIV-1, Antibody, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090ce5f96564c2f360c725e20d3eac51Test
https://europepmc.org/articles/PMC7149231Test/

المؤلفون: Nicole Manfredonia, Barton F. Haynes, Rachael Judson, Frederick W. Alt, Peyton Waddicor, Michael T. Kimble, Hwei-Ling Cheng, Ming Tian, Lisa Rieble, Yiwei Chen, Aimee Chapdelaine-Williams, Elizabeth Cantor, Derek W. Cain, Kelly McGovern, Mai Dao

مصطلحات موضوعية: Genetically modified mouse, Affinity maturation, Negative selection, medicine.anatomical_structure, biology, Central B cell deletion, biology.protein, medicine, Antibody, Progenitor cell, Immunoglobulin light chain, Virology, B cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7f499dfc38633558a6f15192f22112Test
https://doi.org/10.1101/2020.01.03.894279Test

المؤلفون: Haiyan Chen, David Easterhoff, Todd Bradley, Peyton Waddicor, Robert J. Edwards, Rory Henderson, Laurent Verkoczy, Heather Desaire, Ming Tian, Frederick W. Alt, Kevin O. Saunders, Barton F. Haynes, Mattia Bonsignori, Aimee M. Chapdelaine-Williams, Wes Rountree, Richard M. Scearce, Allen L. Hsu, Nelson R. Wu, David C. Montefiori, Amanda Eaton, Xiaozhi Lu, Kevin Wiehe, Brian E. Watts, Hwei-Ling Cheng, Mark G. Lewis, Laura L. Sutherland, Mario J. Borgnia, Kelly McGovern, Eden P. Go, Chuancang Jiang, Priyamvada Acharya, Mark A. Tomai, Jinsong Zhang, S. Munir Alam, Derek W. Cain

المصدر: Science (New York, N.Y.). 366(6470)

مصطلحات موضوعية: 0301 basic medicine, Lineage (genetic), Immunogen, medicine.drug_class, Antibody Affinity, HIV Infections, HIV Antibodies, Monoclonal antibody, medicine.disease_cause, Article, Affinity maturation, 03 medical and health sciences, Epitopes, Mice, 0302 clinical medicine, medicine, Animals, Humans, Gene Knock-In Techniques, Selection, Genetic, Neutralizing antibody, AIDS Vaccines, Mutation, B-Lymphocytes, Multidisciplinary, biology, env Gene Products, Human Immunodeficiency Virus, Cytidine deaminase, Antibodies, Neutralizing, Virology, Mice, Mutant Strains, 030104 developmental biology, biology.protein, HIV-1, Macaca, Antibody, Broadly Neutralizing Antibodies, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5d2f9ecc587086b72b0d4b9f7bcf1bTest
https://pubmed.ncbi.nlm.nih.gov/31875058Test

المؤلفون: Ming Tian¹, Hwei-Ling Cheng¹, Kimble, Michael T.¹, McGovern, Kelly¹, Waddicor, Peyton¹, Yiwei Chen¹, Cantor, Elizabeth¹, Mengting Qiu¹, Tuchel, Marie-Elen¹, Mai Dao¹, Alt, Frederick W.¹ alt@enders.tch.harvard.edu

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 3/9/2021, Vol. 118 Issue 10, p1-11. 11p.

مصطلحات موضوعية: *B cell receptors, *IMMUNOGLOBULINS, *GERMINAL centers, *IMMUNOGLOBULIN genes, *B cells

المؤلفون: Hwei-Ling Cheng, Frederick W. Alt, William R. Schief, Barton F. Haynes, Eric Georgeson, Suvi Jain, Yiwei Chen, John R. Mascola, Wei Shi, Mai Dao, Michael T. Kimble, Zhou Du, Pei-Yi Huang, M. Gordon Joyce, Andrew T. McGuire, Ming Tian, Zizhang Sheng, Nicole A. Doria-Rose, Rita E. Chen, Sherry Lin, Yi Zhang, Leonidas Stamatatos, Sergey Menis, Erica Normandin, Farida Laboune, Amy R. Henry, Daniel C. Douek, Yimin Chen, Stephen D. Schmidt, Lawrence Shapiro, Lingshu Wang, Wing-Pui Kong, Hongying Duan, Elizabeth Cantor, Ivelin S. Georgiev, Brandon J. DeKosky, Misook Choe, Peter D. Kwong, Cheng Cheng, Xuejun Chen

مصطلحات موضوعية: 0301 basic medicine, HIV Infections, HIV Antibodies, Immunoglobulin light chain, General Biochemistry, Genetics and Molecular Biology, Germline, Article, Affinity maturation, 03 medical and health sciences, 0302 clinical medicine, Humans, Neutralizing antibody, chemistry.chemical_classification, AIDS Vaccines, biology, Envelope glycoprotein GP120, Virology, Antibodies, Neutralizing, 3. Good health, 030104 developmental biology, chemistry, biology.protein, HIV-1, Immunoglobulin heavy chain, Antibody, Glycoprotein, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b2ad5e362ec318e636379745cc527dTest
https://europepmc.org/articles/PMC5103708Test/

المؤلفون: Ming Tian, McGovern, Kelly, Hwei-Ling Cheng, Waddicora, Peyton, Rieble, Lisa, Mai Dao, Yiwei Chen, T. Kimble, Michael, Cantor, Elizabeth, Manfredonia, Nicole, Judson, Rachael, Chapdelaine-Williams, Aimee, Cain, Derek W., Haynes, Barton F., Alt, Frederick W.

المصدر: Proceedings of the National Academy of Sciences of the United States of America; 4/7/2020, Vol. 117 Issue 14, p7929-7940, 12p

مصطلحات موضوعية: B cells, BONE marrow cells, VACCINES, TRANSGENIC mice, MICE

المؤلفون: Fredrick W. Alt, Marjan Gucek, Elizabeth Murphy, Guanghui Wang, Guang Tong, In Hye Lee, Renee Wong, Ilsa I. Rovira, Nisha Narayan, Jie Liu, Ronen Borenstein, Toren Finkel, Hwei Ling Cheng, Michael N. Sack, Junhui Sun, Maria M. Fergusson, Liu Cao, David B. Lombard

المصدر: Nature. 492:199-204

مصطلحات موضوعية: Male, Necrosis, Regulator, Biology, SIRT2, Jurkat cells, Article, Cell Line, Jurkat Cells, Mice, Sirtuin 2, medicine, Animals, Humans, Gene knockdown, Multidisciplinary, HEK 293 cells, Acetylation, Molecular biology, Cell biology, Nuclear Pore Complex Proteins, HEK293 Cells, Receptor-Interacting Protein Serine-Threonine Kinases, Female, Tumor necrosis factor alpha, medicine.symptom, HeLa Cells, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6c6faac3cede9a1675100ae91f9ca9Test
https://doi.org/10.1038/nature11700Test

المؤلفون: Claudia Bossen, Chunguang Guo, Frederick W. Alt, Andrew Franklin, Darienne Myers, Michael P. Gallagher, Suvi Jain, Cosmas Giallourakis, Orion Despo, Erica Hansen, Jamie G. Bates, Christian Vettermann, Meinrad Busslinger, Anja Ebert, Harin Patel, Cornelis Murre, Mark S. Schlissel, Nicholas Richards, Hwei-Ling Cheng, Hye Suk Yoon

المصدر: Nature

مصطلحات موضوعية: CCCTC-Binding Factor, Transcription, Genetic, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Immunoglobulin Variable Region, chemical and pharmacologic phenomena, Thymus Gland, Regulatory Sequences, Nucleic Acid, Insulator (genetics), Biology, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Animals, Cell Lineage, Enhancer, 030304 developmental biology, Feedback, Physiological, Recombination, Genetic, B-Lymphocytes, 0303 health sciences, Multidisciplinary, V(D)J recombination, Gene rearrangement, Chromosomes, Mammalian, Molecular biology, Repressor Proteins, Allelic exclusion, Enhancer Elements, Genetic, Germ Cells, CTCF, Mutation, Immunoglobulin heavy chain, DNA, Intergenic, VDJ Exons, Immunoglobulin Heavy Chains, Recombination, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5446cabed3ddca3fc79ee964a64843c9Test
https://doi.org/10.1038/nature10495Test