المؤلفون: Singh, Jay K, Hutt, Darren M, Tait, Bradley, Guy, Naihsuan C, Sivils, Jeffrey C, Ortiz, Nina R, Payan, Ashley N, Komaragiri, Shravan Kumar, Owens, Jazzmin Jovonna, Culbertson, David, Blair, Laura J, Dickey, Chad, Kuo, Szu Yu, Finley, Dan, Dyson, H Jane, Cox, Marc B, Chaudhary, Jaideep, Gestwicki, Jason E, Balch, William E

المصدر: Cell Chemical Biology. 27(3)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Urologic Diseases, Biotechnology, Cancer, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Acquired Cognitive Impairment, Dementia, Prostate Cancer, Alzheimer's Disease, Brain Disorders, Aging, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, HEK293 Cells, HSP90 Heat-Shock Proteins, Humans, Molecular Chaperones, Molecular Structure, Protein Folding, Small Molecule Libraries, Aha1, Alzheimer disease, androgen receptor, heat shock protein 90, prostate cancer, tau, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3k55j4vxTest

المؤلفون: Wang, Chao, Scott, Samantha M, Sun, Shuhong, Zhao, Pei, Hutt, Darren M, Shao, Hao, Gestwicki, Jason E, Balch, William E

المصدر: Human Molecular Genetics. 29(1)

مصطلحات موضوعية: Genetics, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Allosteric Regulation, Cholesterol, Cytosol, Endoplasmic Reticulum, Endosomes, Genetic Variation, HSP70 Heat-Shock Proteins, Humans, Lysosomes, Niemann-Pick C1 Protein, Niemann-Pick Disease, Type C, Biological Sciences, Medical and Health Sciences, Genetics & Heredity

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4c60d591Test

المؤلفون: Wang, Chao, Scott, Samantha M, Subramanian, Kanagaraj, Loguercio, Salvatore, Zhao, Pei, Hutt, Darren M, Farhat, Nicole Y, Porter, Forbes D, Balch, William E

المصدر: Nature communications. 10(1)

مصطلحات موضوعية: Cell Line, Tumor, Hela Cells, Endosomes, Lysosomes, Fibroblasts, Humans, Cholesterol, Regression Analysis, Normal Distribution, Epigenesis, Genetic, Structure-Activity Relationship, Homeostasis, Lipid Metabolism, Niemann-Pick Disease, Type C, Histone Deacetylase Inhibitors, Proteostasis Deficiencies, Epigenomics, Machine Learning, Niemann-Pick C1 Protein, Vorinostat, HeLa Cells, Cell Line, Tumor, Epigenesis, Genetic, Niemann-Pick Disease, Type C

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/16k6n8sdTest

المؤلفون: Hutt, Darren M, Loguercio, Salvatore, Campos, Alexandre Rosa, Balch, William E

المصدر: Journal of Molecular Biology. 430(18)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Genetics, Lung, Cystic Fibrosis, Rare Diseases, Human Genome, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Congenital, Good Health and Well Being, Biomarkers, Gene Expression Profiling, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Mutation, Precision Medicine, Proteome, Proteomics, Ivacaftor, Lumacaftor, cystic fibrosis, disease-associated variants, protein interaction profile, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Microbiology, Biochemistry & Molecular Biology, Biochemistry and cell biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/78c5d480Test

المؤلفون: Hutt, Darren M, Loguercio, Salvatore, Roth, Daniela Martino, Su, Andrew I, Balch, William E

المصدر: Journal of Biological Chemistry. 293(35)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Rare Diseases, Genetics, Lung, Human Genome, Cystic Fibrosis, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Aetiology, Underpinning research, Generic health relevance, Cell Line, Cystic Fibrosis Transmembrane Conductance Regulator, Eukaryotic Initiation Factor-3, Humans, Mutation, Peptide Chain Initiation, Translational, Phenylalanine, Protein Folding, Protein Interaction Maps, Protein Transport, RNA Interference, RNA, Small Interfering, F508del-CFTR, cystic fibrosis, cystic fibrosis transmembrane conductance regulator, eIF3a, eukaryotic translation initiation, eukaryotic translation initiation factor 3, network hub, protein misfolding, protein translation, proteostasis, translation initiation factor, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/4kr9v5p0Test

المؤلفون: Roth, Daniela Martino, Hutt, Darren M, Tong, Jiansong, Bouchecareilh, Marion, Wang, Ning, Seeley, Theo, Dekkers, Johanna F, Beekman, Jeffrey M, Garza, Dan, Drew, Lawrence, Masliah, Eliezer, Morimoto, Richard I, Balch, William E

المصدر: PLoS biology. 12(11)

مصطلحات موضوعية: Respiratory Mucosa, Organoids, Cell Line, Animals, Mice, Transgenic, Humans, Caenorhabditis elegans, Cystic Fibrosis, Epoxy Compounds, Diterpenes, Phenanthrenes, Intramolecular Oxidoreductases, Cystic Fibrosis Transmembrane Conductance Regulator, DNA-Binding Proteins, Transcription Factors, Antineoplastic Agents, Alkylating, Drug Evaluation, Preclinical, Gene Silencing, Protein Folding, Stress, Physiological, Proteostasis Deficiencies, Prostaglandin-E Synthases, Heat Shock Transcription Factors, Mice, Transgenic, Antineoplastic Agents, Alkylating, Drug Evaluation, Preclinical, Stress, Physiological, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2qf8w6hrTest

المؤلفون: Amaral, Margarida D., Hutt, Darren M, Tomati, Valeria, Botelho, Hugo M., Pedemonte, Nicoletta

المساهمون: Ministero della Salute, Fondazione per la Ricerca sulla Fibrosi Cistica, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa

المصدر: Journal of Cystic Fibrosis ; volume 19, page S33-S36 ; ISSN 1569-1993

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.jcf.2019.10.017Test
https://api.elsevier.com/content/article/PII:S1569199319309324?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1569199319309324?httpAccept=text/plainTest

المؤلفون: Subramanian, Kanagaraj, Hutt, Darren M., Scott, Samantha M., Gupta, Vijay, Mao, Shu, Balch, William E.

المساهمون: HHS | NIH | National Heart, Lung, and Blood Institute, HHS | NIH | National Institute on Aging, Ara Parseghian Medical Research Foundation, Support Of Accelerated Research for Niemann-Pick Type C Disease

المصدر: Journal of Biological Chemistry ; volume 295, issue 23, page 8017-8035 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.ra119.010524Test
https://api.elsevier.com/content/article/PII:S0021925817494403?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925817494403?httpAccept=text/plainTest

المؤلفون: Wang, Chao, Scott, Samantha M, Sun, Shuhong, Zhao, Pei, Hutt, Darren M, Shao, Hao, Gestwicki, Jason E, Balch, William E

المساهمون: National Institutes of Health, Ara Parseghian Medical Research Foundation

المصدر: Human Molecular Genetics ; volume 29, issue 1, page 1-19 ; ISSN 0964-6906 1460-2083

الإتاحة: https://doi.org/10.1093/hmg/ddz215Test
http://academic.oup.com/hmg/article-pdf/29/1/1/32353012/ddz215.pdfTest

المؤلفون: Hutt, Darren M., Mishra, Sanjay Kumar, Roth, Daniela Martino, Larsen, Mads Breum, Angles, Frédéric, Frizzell, Raymond A., Balch, William E.

المساهمون: HHS | National Institutes of Health, HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), HHS | NIH | National Institute on Aging (NIA)

المصدر: Journal of Biological Chemistry ; volume 293, issue 35, page 13682-13695 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.ra118.002607Test
https://api.elsevier.com/content/article/PII:S0021925820309984?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820309984?httpAccept=text/plainTest