دورية أكاديمية
Invasive bone and joint infections from the French Scedosporiosis/lomentosporiosis Observational Study (SOS) cohort: no mortality with long-term antifungal treatment and surgery
| العنوان: | Invasive bone and joint infections from the French Scedosporiosis/lomentosporiosis Observational Study (SOS) cohort: no mortality with long-term antifungal treatment and surgery |
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| المؤلفون: | Blez, Damien, Bronnimann, Didier, Rammaert, Blandine, Zeller, Valérie, Delhaes, Laurence, Hustache, Laurent, Grenouillet, Frédéric, Traversier, Nicolas, Bonhomme, Julie, Chouaki, Taieb, Perpoint, Thomas, Persat, Florence, Bougnoux, Marie Elisabeth, Bayle, Sophie, Quaesaet, Luc, Nevez, Gilles, Boutoille, David, Morio, Florent, Pougnet, Laurence, Queyrel-Moranne, Viviane, Heym, B́eate, Guillemain, Romain, Dannaoui, Éric, Roux, Antoine, Garcia-Hermoso, Dea, Lanternier, Fanny |
| المساهمون: | Hôpital Foch Suresnes, Service de pneumologie Hôpital Foch, Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | ISSN: 1369-3786. |
| بيانات النشر: | HAL CCSD Oxford University Press |
| سنة النشر: | 2023 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | Lomentospora, Scedosporium, arthritis, bone infections, osteomyelitis, scedosporiosis, [SDV]Life Sciences [q-bio], [SHS]Humanities and Social Sciences |
| الوصف: | International audience ; Abstract Little is known about localized osteoarticular Scedosporiosis (LOS). Most data come from case reports and small case series. Here we present an ancillary study of the nationwide French Scedosporiosis Observational Study (SOS), describing 15 consecutive cases of LOS diagnosed between January 2005 and March 2017. Adult patients diagnosed with LOS defined by osteoarticular involvement without distant foci reported in SOS were included. Fifteen LOS were analyzed. Seven patients had underlying disease. Fourteen patients had prior trauma as potential inoculation. Clinical presentation was arthritis (n = 8), osteitis (n = 5), and thoracic wall infection (n = 2). The most common clinical manifestation was pain (n = 9), followed by localized swelling (n = 7), cutaneous fistulization (n = 7), and fever (n = 5). The species involved were Scedosporium apiospermum (n = 8), S. boydii (n = 3), S. dehoogii (n = 1), and Lomentospora prolificans (n = 3). The species distribution was unremarkable except for S. boydii, which was associated with healthcare-related inoculations. Management was based on medical and surgical treatment for 13 patients. Fourteen patients received antifungal treatment for a median duration of 7 months. No patients died during follow-up. LOS exclusively occurred in the context of inoculation or systemic predisposing factors. It has a non-specific clinical presentation and is associated with an overall good clinical outcome, provided there is a prolonged course of antifungal therapy and adequate surgical management. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04481972; https://hal.science/hal-04481972Test |
| DOI: | 10.1093/mmy/myad023 |
| الإتاحة: | https://doi.org/10.1093/mmy/myad023Test https://hal.science/hal-04481972Test |
| رقم الانضمام: | edsbas.DC627D36 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/mmy/myad023 |
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