المؤلفون: Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I. J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J. A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodriguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco

المساهمون: Helsinki Institute of Life Science HiLIFE, Centre of Excellence in Stem Cell Metabolism, Institute of Biotechnology, Molecular and Integrative Biosciences Research Programme, University of Helsinki

مصطلحات موضوعية: IN-VIVO, COMPETITION, GENERATION, PLATFORM, PATTERN, MARKER, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: We thank the members of the van Rheenen laboratory for reading the manuscript, and the members of the bioimaging, FACS and animal facility of the NKI for experimental support. We acknowledge the staff at the MedH Flow Cytometry core facility, Karolinska Institutet, and LCI facility/Nikon Center of Excellence, Karolinska Institutet. This work was financially supported by the Netherlands Organization of Scientific Research NWO (Veni grant 863.15.011 to S.I.J.E. and Vici grant 09150182110004 to J.v.R.) and the CancerGenomics.nl (Netherlands Organisation for Scientific Research) program (to J.v.R.) the Doctor Josef Steiner Foundation (to J.v.R). B.D.S. acknowledges funding from the Royal Society E.P. Abraham Research Professorship (RP\R1\180165) and the Wellcome Trust (098357/Z/12/Z and 219478/Z/19/Z). B.C.-M. acknowledges the support of the field of excellence `Complexity of life in basic research and innovation' of the University of Graz. O.J.S. and their laboratory acknowledge CRUK core funding to the CRUK Beatson Institute (A17196 and A31287) and CRUK core funding to the Sansom laboratory (A21139). P.K. and their laboratory are supported by grants from the Swedish Research Council (2018-03078), Cancerfonden (190634), Academy of Finland Centre of Excellence (266869, 304591 and 320185) and the Jane and Aatos Erkko Foundation. P.L. has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 758617). E.H. acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 851288).; Azkanaz , M , Corominas-Murtra , B , Ellenbroek , S I J , Bruens , L , Webb , A T , Laskaris , D , Oost , K C , Lafirenze , S J A , Annusver , K , Messal , H A , Iqbal , S , Flanagan , D J , Huels , D J , Rojas-Rodriguez , F , Vizoso , M , Kasper , M , Sansom , O J , Snippert , H J , Liberali , P , Simons , B D , Katajisto , P , Hannezo , E & van Rheenen , J 2022 , ' Retrograde movements determine effective stem cell numbers in the intestine ' , Nature , vol. 607 , no. 7919 , pp. 548-+ . https://doi.org/10.1038/s41586-022-04962-0Test; 844f1b03-67b0-41f6-9d6a-84d7cebda907; http://hdl.handle.net/10138/355501Test; 000824430000004

الإتاحة: http://hdl.handle.net/10138/355501Test

المؤلفون: Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Eggington, Holly R, Schenck, Ryan O, Wouters, Valérie M, Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R M, Flanagan, Dustin J, Najumudeen, Arafath K, Omwenga, Sulochana, McCorry, Amy M B, Easton, Alistair, Koelzer, Viktor H, East, James E, Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D, Loughrey, Maurice B, Dunne, Philip D, Tsantoulis, Petros, Huels, David J, Tejpar, Sabine, Sansom, Owen J, Leedham, Simon J

المساهمون: Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Eggington, Holly R, Schenck, Ryan O, Wouters, Valérie M, Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R M, Flanagan, Dustin J, Najumudeen, Arafath K, Omwenga, Sulochana, McCorry, Amy M B, Easton, Alistair, Koelzer, Viktor H, East, James E, Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D, Loughrey, Maurice B, Dunne, Philip D, Tsantoulis, Petro, Huels, David J, Tejpar, Sabine, Sansom, Owen J, Leedham, Simon J

مصطلحات موضوعية: cell plasticity, colorectal cancer, colorectal neoplasia, intestinal polyp, intestinal stem cell, molecular phenotyping, stem cell, Animal, Homeostasi, Human, Intestine, Mice, Neoplastic Stem Cell, Receptors, G-Protein-Coupled, Colorectal Neoplasm, Intestinal Mucosa

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35931031; info:eu-repo/semantics/altIdentifier/wos/WOS:000843892000007; volume:29; issue:8; firstpage:1213; lastpage:1228; numberofpages:16; journal:CELL STEM CELL; https://hdl.handle.net/2318/1880629Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85135464912

الإتاحة: https://doi.org/10.1016Test/j.stem.2022.07.008
https://hdl.handle.net/2318/1880629Test

المؤلفون: Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I. J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J. A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodríguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard B, van Rheenen, Jacco

المصدر: Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, et al. Retrograde movements determine effective stem cell numbers in the intestine. Nature . 2022;607(7919):548-554. doi: 10.1038/s41586-022-04962-0

مصطلحات موضوعية: Multidisciplinary

العلاقة: info:eu-repo/semantics/altIdentifier/issn/0028-0836; info:eu-repo/semantics/altIdentifier/issn/1476-4687; info:eu-repo/semantics/altIdentifier/wos/000824430000004; info:eu-repo/semantics/altIdentifier/pmid/35831497; info:eu-repo/grantAgreement/EC/H2020/851288; https://research-explorer.ista.ac.at/record/12274Test

الإتاحة: https://doi.org/10.1038/s41586-022-04962-0Test
https://research-explorer.ista.ac.at/record/12274Test

المؤلفون: van Neerven, Sanne M., Ramadan, Rana, van Driel, Milou S., Huels, David J., Vermeulen, Louis

المساهمون: ZonMw, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, KWF Kankerbestrijding, New York Stem Cell Foundation, Maag Lever Darm Stichting, European Research Council, Worldwide Cancer Research

المصدر: STAR Protocols ; volume 3, issue 1, page 101050 ; ISSN 2666-1667

مصطلحات موضوعية: General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Neuroscience

الإتاحة: https://doi.org/10.1016Test/j.xpro.2021.101050
https://api.elsevier.com/content/article/PII:S2666166721007565?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666166721007565?httpAccept=text/plainTest

المؤلفون: Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.

المصدر: Cell Stem Cell ; volume 29, issue 11, page 1612 ; ISSN 1934-5909

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Medicine

الإتاحة: https://doi.org/10.1016Test/j.stem.2022.09.005
https://api.elsevier.com/content/article/PII:S1934590922003824?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1934590922003824?httpAccept=text/plainTest

المؤلفون: Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, Maughan, Tim, Salto-Tellez, Manuel, Quirke, Philip, Koelzer, Viktor, Dunne, Philip, Beggs, Andrew, Campbell, Peter, Buffa, Francesca, Holmes, Chris, Kaplan, Rick, Brown, Louise, Lawler, Mark, Hordern, Joshua, Tomlinson, Ian, Leedham, Simon, Morton, Dion, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.

المصدر: ISSN: 2041-1723 ; Nature communications, vol. 12, no. 1 (2021) 3464.

مصطلحات موضوعية: info:eu-repo/classification/ddc/616

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34103493; info:eu-repo/semantics/dataset/url/https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE168478Test; info:eu-repo/grantAgreement/EC/FP7/311301/EU/Targeting downstream effectors of Wnt signaling in colorectal cancer/COLONCAN; info:eu-repo/grantAgreement/EC/H2020/659666/EU/Characterization of Intestinal Cancer Cell Invasion/CICCI; https://archive-ouverte.unige.ch/unige:161332Test; unige:161332

الإتاحة: https://doi.org/10.1038/s41467-021-23717-5Test
https://archive-ouverte.unige.ch/unige:161332Test

المؤلفون: Leach, Joshua D.G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret, Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J., Maughan, Tim, Salto-Tellez, Manuel, Quirke, Philip, Koelzer, Viktor, Dunne, Philip, Beggs, Andrew, Campbell, Peter, Buffa, Francesca, Holmes, Chris, Kaplan, Rick, Brown, Louise, Lawler, Mark, Hordern, Joshua, Tomlinson, Ian, Leedham, Simon, Morton, Dion

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/243747/1/243747.pdfTest; Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications , 12, 3464. (doi:10.1038/s41467-021-23717-5 ) (PMID:34103493) (PMCID:PMC8187652)

الإتاحة: https://doi.org/10.1038/s41467-021-23717-5Test
https://eprints.gla.ac.uk/243747Test/
https://eprints.gla.ac.uk/243747/1/243747.pdfTest

المؤلفون: Huels, David J., Ridgway, Rachel A., Radulescu, Sorina, Leushacke, Marc, Campbell, Andrew D., Biswas, Sujata, Leedham, Simon, Serra, Stefano, Chetty, Runjan, Moreaux, Guenievre, Parry, Lee, Matthews, James, Song, Fei, Hedley, Ann, Kalna, Gabriela, Ceteci, Fatih, Reed, Karen R., Meniel, Valerie S., Maguire, Aoife, Doyle, Brendan, Soderberg, Ola, Barker, Nick, Watson, Alastair, Larue, Lionel, Clarke, Alan R., Sansom, Owen J.

المصدر: EMBO Journal. 34(18):2321-2333

مصطلحات موضوعية: APC, beta-catenin, colorectal cancer, E-cadherin

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265922Test
https://doi.org/10.15252/embj.201591739Test
http://emboj.embopress.org/content/34/18/2321Test

المؤلفون: Song, Je-Hoon, Huels, David J., Ridgway, Rachel A., Kholodenko, Boris N., Kolch, Walter

مصطلحات موضوعية: APC, Computational modeling, In vivo experimentation, Adenomatous polyposis coli mutations, β-catenin, Colonic crypts

العلاقة: Cell Reports; http://hdl.handle.net/10197/9789Test; 94; 103; 2010-0017662; 06/CE/B1129; 278568

الإتاحة: https://doi.org/10.1016Test/j.celrep.2014.02.043
http://hdl.handle.net/10197/9789Test

المؤلفون: Gay, David M., Ridgway, Rachel A., Müeller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.

وصف الملف: text

العلاقة: https://eprints.gla.ac.uk/180963/1/180963.pdfTest; Gay, D. M. et al. (2019) Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications , 10, 723. (doi:10.1038/s41467-019-08586-3 ) (PMID:30760720) (PMCID:PMC6374445)

الإتاحة: https://doi.org/10.1038/s41467-019-08586-3Test
https://eprints.gla.ac.uk/180963Test/
https://eprints.gla.ac.uk/180963/1/180963.pdfTest