دورية أكاديمية
Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis
| العنوان: | Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis |
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| المؤلفون: | Yi-Fang Yang, Chien-Hsiu Li, Huei-Yu Cai, Bo-Syuan Lin, Cheorl-Ho Kim, Yu-Chan Chang |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 24, p 15831 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | cancer metabolism, metabolic reprogramming, molecular imaging, cellular uptake, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Cellular metabolism governs the signaling that supports physiological mechanisms and homeostasis in an individual, including neuronal transmission, wound healing, and circadian clock manipulation. Various factors have been linked to abnormal metabolic reprogramming, including gene mutations, epigenetic modifications, altered protein epitopes, and their involvement in the development of disease, including cancer. The presence of multiple distinct hallmarks and the resulting cellular reprogramming process have gradually revealed that these metabolism-related molecules may be able to be used to track or prevent the progression of cancer. Consequently, translational medicines have been developed using metabolic substrates, precursors, and other products depending on their biochemical mechanism of action. It is important to note that these metabolic analogs can also be used for imaging and therapeutic purposes in addition to competing for metabolic functions. In particular, due to their isotopic labeling, these compounds may also be used to localize and visualize tumor cells after uptake. In this review, the current development status, applicability, and limitations of compounds targeting metabolic reprogramming are described, as well as the imaging platforms that are most suitable for each compound and the types of cancer to which they are most appropriate. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/23/24/15831Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms232415831 |
| الوصول الحر: | https://doaj.org/article/7292f4a8eab44e6bac9833095f01c920Test |
| رقم الانضمام: | edsdoj.7292f4a8eab44e6bac9833095f01c920 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms232415831 |