التفاصيل البيبلوغرافية
| العنوان: |
Characterization of the skin microbiota in bullous pemphigoid patients and controls reveals novel microbial indicators of disease |
| المؤلفون: |
Belheouane, M. (Meriem), Hermes, B. M. (Britt M.), Van Beek, N. (Nina), Benoit, S. (Sandrine), Bernard, P. (Philippe), Drenovska, K. (Kossara), Gerdes, S. (Sascha), Gläser, R. (Regine), Goebeler, M. (Matthias), Günther, C. (Claudia), von Georg, A. (Anabelle), Hammers, C. M. (Christoph M.), Holtsche, M. M. (Maike M.), Homey, B. (Bernhard), Horváth, O. N. (Orsolya N.), Hübner, F. (Franziska), Linnemann, B. (Beke), Joly, P. (Pascal), Márton, D. (Dalma), Patsatsi, A. (Aikaterini), Pföhler, C. (Claudia), Sárdy, M. (Miklós), Huilaja, L. (Laura), Vassileva, S. (Snejina), Zillikens, D. (Detlef), Ibrahim, S. (Saleh), Sadik, C. D. (Christian D.), Schmidt, E. (Enno), Baines, J. F. (John F.) |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2023 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
16s rRNA gene sequencing, Autoimmune blistering disease, Bullous pemphigoid, Risk factor, Skin microbiota |
| الوصف: |
Introduction: Bullous pemphigoid (BP) is the most common autoimmune blistering disease. It predominately afflicts the elderly and is significantly associated with increased mortality. The observation of age-dependent changes in the skin microbiota as well as its involvement in other inflammatory skin disorders suggests that skin microbiota may play a role in the emergence of BP blistering. We hypothesize that changes in microbial diversity associated with BP might occur before the emergence of disease lesions, and thus could represent an early indicator of blistering risk. Objectives: The present study aims to investigate potential relationships between skin microbiota and BP and elaborate on important changes in microbial diversity associated with blistering in BP. Methods: The study consisted of an extensive sampling effort of the skin microbiota in patients with BP and age- and sex-matched controls to analyze whether intra-individual, body site, and/or geographical variation correlate with changes in skin microbial composition in BP and/or blistering status. Results: We find significant differences in the skin microbiota of patients with BP compared to that of controls, and moreover that disease status rather than skin biogeography (body site) governs skin microbiota composition in patients with BP. Our data reveal a discernible transition between normal skin and the skin surrounding BP lesions, which is characterized by a loss of protective microbiota and an increase in sequences matching Staphylococcus aureus, a known inflammation-promoting species. Notably, Staphylococcus aureus is ubiquitously associated with BP disease status, regardless of the presence of blisters. Conclusion: The present study suggests Staphylococcus aureus may be a key taxon associated with BP disease status. Importantly, we however find contrasting patterns in the relative abundances of Staphylococcus hominis and Staphylococcus aureus reliably discriminate between patients with BP and matched controls. This may serve as ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe2023071390605Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0Test/). ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.24E04F34 |
| قاعدة البيانات: |
BASE |
