دورية أكاديمية
Framework for Implementing and Tracking a Molecular Tumor Board at a National Cancer Institute–Designated Comprehensive Cancer Center
| العنوان: | Framework for Implementing and Tracking a Molecular Tumor Board at a National Cancer Institute–Designated Comprehensive Cancer Center |
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| المؤلفون: | Jain, Neha M., Schmalz, Lauren, Cann, Christopher, Holland, Adara, Osterman, Travis, Lang, Katie, Wiesner, Georgia L., Pal, Tuya, Lovly, Christine, Stricker, Thomas, Micheel, Christine, Balko, Justin M., Johnson, Douglas B., Park, Ben Ho, Iams, Wade |
| المساهمون: | Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Comprehensive Cancer Network |
| المصدر: | The Oncologist ; volume 26, issue 11, page e1962-e1970 ; ISSN 1083-7159 1549-490X |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, Oncology |
| الوصف: | Background Over the past few years, tumor next-generation sequencing (NGS) panels have evolved in complexity and have changed from selected gene panels with a handful of genes to larger panels with hundreds of genes, sometimes in combination with paired germline filtering and/or testing. With this move toward increasingly large NGS panels, we have rapidly outgrown the available literature supporting the utility of treatments targeting many reported gene alterations, making it challenging for oncology providers to interpret NGS results and make a therapy recommendation for their patients. Methods To support the oncologists at Vanderbilt-Ingram Cancer Center (VICC) in interpreting NGS reports for patient care, we initiated two molecular tumor boards (MTBs)—a VICC-specific institutional board for our patients and a global community MTB open to the larger oncology patient population. Core attendees include oncologists, hematologist, molecular pathologists, cancer geneticists, and cancer genetic counselors. Recommendations generated from MTB were documented in a formal report that was uploaded to our electronic health record system. Results As of December 2020, we have discussed over 170 patient cases from 77 unique oncology providers from VICC and its affiliate sites, and a total of 58 international patient cases by 25 unique providers from six different countries across the globe. Breast cancer and lung cancer were the most presented diagnoses. Conclusion In this article, we share our learning from the MTB experience and document best practices at our institution. We aim to lay a framework that allows other institutions to recreate MTBs. Implications for Practice With the rapid pace of molecularly driven therapies entering the oncology care spectrum, there is a need to create resources that support timely and accurate interpretation of next-generation sequencing reports to guide treatment decision for patients. Molecular tumor boards (MTB) have been created as a response to this knowledge gap. This report ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/onco.13936 |
| الإتاحة: | https://doi.org/10.1002/onco.13936Test https://academic.oup.com/oncolo/article-pdf/26/11/e1962/42203910/oncolo_26_11_e1962.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.3EFDCDE8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/onco.13936 |
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