التفاصيل البيبلوغرافية
| العنوان: |
Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm-graecum) improve tibial bone defects repair in rabbits? A preliminary study. |
| المؤلفون: |
Sadan, Madeh, Naem, Mommen, Tawfeek, Hesham M., Khodier, Mostafa M., Zeitoun, Moustafa Mohamed, El-Khodery, Sabry, Alkhamiss, Abdullah Saleh, Hofny Hassan, Yaser Abdallah, Abdellatif, Ahmed A. H. |
| المصدر: |
Open Veterinary Journal; 2024, Vol. 14 Issue 5, p1281-1293, 13p |
| مصطلحات موضوعية: |
RABBITS, FENUGREEK, BONE remodeling, UBIQUINONES, SURFACE charges, FRACTURE healing, BONE growth |
| مستخلص: |
Background: A fracture is considered a medical emergency leading to considerable complications. Aim: This study aimed to describe the accelerating action of Ag-NPs-FG on fracture healing in rabbits. Methods: Silver NPs (AgNPs) were reduced with fenugreek (FG), loaded into a starch gel base, and investigated for their morphology, size, and charge. Four equal groups were randomly formed of 40 adult male rabbits. A 3.5 mm diameter bone defect was created at the proximal metaphysis of the right tibia in each rabbit. Groups 1-4 were injected with placebo saline, AgNPs-FG, plain gel, and FG-gel at the bone defect zone, respectively. The healing was assessed for 8 weeks postoperatively based on the radiographic, bone turnover markers, and histopathological examinations. Results: The AgNPs-FG was obtained as a faint reddish color, spherical in shape, with an absorbance of 423 nm, a size of 118.0 ± 1.7 nm, and a surface charge of -7.8 ± 0.518 mV. The prepared AgNPs-FG hydrogel was clear, translucent, and homogenous. The pH values were 6.55-6.5 ± 0.2, the viscosity of 4,000 and 1,875 cPs, and spreadability of 1.6 ± 0.14 and 2.0 ± 0.15 for both FG and AgNPs-FG hydrogel, respectively. The radiographic union scale was significantly (p < 0.05) improved in group 2 with a significant (p < 0.05) increase in bone turnover markers was found in comparison to other treated groups. Histopathological examination revealed the formation of mature bone on the 28th postoperative day in groups 2 and 4. Conclusion: Colloidal nano-formulation of AgNPs-FG loaded hydrogel could be a promising formulation to accelerate rabbits' tibial bone healing process. [ABSTRACT FROM AUTHOR] |
|
Copyright of Open Veterinary Journal is the property of Open Veterinary Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder