Risk factors for anal cancer in persons infected with HIV: a nested case-control study in the Swiss HIV Cohort Study
| العنوان: | Risk factors for anal cancer in persons infected with HIV: a nested case-control study in the Swiss HIV Cohort Study |
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| المؤلفون: | Bertisch, B., silvia franceschi, Lise, M., Vernazza, P., Keiser, O., Schöni-Affolter, F., Bouchardy, C., Dehler, S., Levi, F., Jundt, G., Ess, S., Pawlita, M., Kovari, H., Wandeler, G., Calmy, A., Cavassini, M., Stöckle, M., Clifford, G., Hiv, Swiss Cohort Study Investigators |
| المساهمون: | University of Zurich, Bertisch, Barbara |
| المصدر: | Scopus-Elsevier Bertisch, Barbara; Franceschi, Silvia; Lise, Mauro; Vernazza, Pietro; Keiser, Olivia; Schöni-Affolter, Franziska; Bouchardy, Christine; Dehler, Silvia; Levi, Fabio; Jundt, Gernot; Ess, Silvia; Pawlita, Michael; Kovari, Helen; Wandeler, Gilles; Calmy, Alexandra; Cavassini, Matthias; Stöckle, Marcel; Clifford, Gary (2013). Risk factors for anal cancer in persons infected with HIV: a nested case-control study in the Swiss HIV Cohort Study. American journal of epidemiology, 178(6), pp. 877-884. Oxford University Press 10.1093/aje/kwt153 <http://dx.doi.org/10.1093/aje/kwt153Test> American Journal of Epidemiology, Vol. 178, No 6 (2013) pp. 877-84 American journal of epidemiology |
| مصطلحات موضوعية: | Male, Epidemiology, Anal Carcinoma, Original Contributions, HIV Infections, Comorbidity, Men who have sex with men, 10234 Clinic for Infectious Diseases, Switzerland/epidemiology, 0302 clinical medicine, Risk Factors, Antiretroviral Therapy, Highly Active, Antiretroviral Therapy, Highly Active/adverse effects/statistics & numerical data, 030212 general & internal medicine, Substance Abuse, Intravenous, Immunodeficiency, ddc:616, Human papillomavirus 16, Incidence, Smoking, Middle Aged, Anus Neoplasms, 3. Good health, 030220 oncology & carcinogenesis, Female, Smoking/adverse effects/epidemiology, Switzerland, Cohort study, Adult, medicine.medical_specialty, 610 Medicine & health, Immunocompromised Host, 03 medical and health sciences, 360 Social problems & social services, Internal medicine, 10049 Institute of Pathology and Molecular Pathology, medicine, Humans, Anal cancer, Homosexuality, Male, Anus Neoplasms/epidemiology/etiology/virology, Substance Abuse, Intravenous/complications, ddc:613, Gynecology, business.industry, Papillomavirus Infections, HIV Infections/complications/drug therapy/epidemiology, Papillomavirus Infections/complications/transmission/virology, Cancer, Odds ratio, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), medicine.disease, CD4 Lymphocyte Count, Homosexuality, Male/statistics & numerical data, Case-Control Studies, Nested case-control study, Human papillomavirus 16/isolation & purification/pathogenicity, business, 2713 Epidemiology |
| الوصف: | Anal cancer is common among people infected with human immunodeficiency virus (HIV). This cancer is caused by human papillomavirus, and immunosuppression likely contributes to its development. In this issue of the Journal, Bertisch et al. (Am J Epidemiol. 2013;178(6):877–884) present the results of a case-control study of anal cancer among HIV-infected people in Switzerland. They demonstrate that anal cancer risk is increased in association with a low CD4+ cell count (a clinical measurement of immune status). In particular, HIV-induced immunosuppression was most severe among cases approximately 6–7 years prior to the diagnosis of anal cancer. A plausible biological interpretation is that immunosuppression is important at an early stage of the development of anal cancer, but that the neoplastic process becomes irreversible over time with persistent human papillomavirus infection and genetic damage. With current efforts to provide earlier combination antiretroviral therapy to HIV-infected people, anal cancer incidence may start to decline. Bertisch et al. also demonstrate a strong association between serum antibodies against the human papillomavirus type 16 protein E6 and anal cancer risk, highlighting the role of this viral oncoprotein in carcinogenesis. Additional biomarkers could help refine clinical approaches to anal cancer screening and prevention for the HIV-infected population. |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; Bertisch_AJEAA_2013.pdf - application/pdf |
| تدمد: | 0002-9262 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a01309ff029f74e93292b633dc68aeTest http://www.scopus.com/inward/record.url?eid=2-s2.0-84887396930&partnerID=MN8TOARSTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....27a01309ff029f74e93292b633dc68ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00029262 |
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