المؤلفون: Zhao, Chunlong, Chen, Deng, Suo, Feng-zhi, Setroikromo, Rita, Quax, Wim J., Dekker, Frank

المصدر: Zhao , C , Chen , D , Suo , F , Setroikromo , R , Quax , W J & Dekker , F 2023 , ' Discovery of highly potent HDAC8 PROTACs with anti-tumor activity ' , Bioorganic Chemistry , vol. 136 , 106546 . https://doi.org/10.1016/j.bioorg.2023.106546Test

مصطلحات موضوعية: Humans, Repressor Proteins, Proteolysis Targeting Chimera, Cell Line, Tumor, Histone Deacetylases/metabolism, Jurkat Cells, Proteolysis, Histone Deacetylase Inhibitors/pharmacology

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/3d9675c4-ed9f-42b6-a5ce-db018f138559Test

الإتاحة: https://doi.org/10.1016/j.bioorg.2023.106546Test
https://hdl.handle.net/11370/3d9675c4-ed9f-42b6-a5ce-db018f138559Test
https://research.rug.nl/en/publications/3d9675c4-ed9f-42b6-a5ce-db018f138559Test
https://pure.rug.nl/ws/files/643992592/1_s2.0_S0045206823002067_main.pdfTest

المؤلفون: Pu, Jingjing, Liu, Ting, Sharma, Amit, Schmidt-Wolf, Ingo G H

المصدر: BMC medical genomics 16(1), 295 (2023). doi:10.1186/s12920-023-01724-3

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Humans, Histone Deacetylases: genetics, Histone Deacetylases: metabolism, Histone Deacetylase 6, Histone Deacetylase Inhibitors: pharmacology, Histone Deacetylase Inhibitors: therapeutic use, MicroRNAs: genetics, Multiple Myeloma: drug therapy, Multiple Myeloma: genetics, Histone Deacetylases, Cancer, Epigenetics, Non-coding genome, Histone Deacetylase Inhibitors, MicroRNAs

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:37978516; info:eu-repo/semantics/altIdentifier/issn/1755-8794; https://pub.dzne.de/record/266012Test; https://pub.dzne.de/search?p=id:%22DZNE-2023-01086%22Test

الإتاحة: https://doi.org/10.1186/s12920-023-01724-3Test
https://pub.dzne.de/record/266012Test
https://pub.dzne.de/search?p=id:%22DZNE-2023-01086%22Test

المؤلفون: Lo Cascio, Costanza, Margaryan, Tigran, Luna-Melendez, Ernesto, McNamara, James B, White, Connor I, Knight, William, Ganta, Saisrinidhi, Opachich, Zorana, Cantoni, Claudia, Yoo, Wonsuk, Sanai, Nader, Tovmasyan, Artak, Mehta, Shwetal

المصدر: Translational Neuroscience

مصطلحات موضوعية: Brain cancer, Drug therapy, Oncology, Radiation therapy, Therapeutics, Adult, Humans, Child, Histone Deacetylase Inhibitors (pharmacology, therapeutic use), Glioblastoma (drug therapy, radiotherapy), Hydroxamic Acids (pharmacology, Histone Deacetylases (metabolism), Brain Neoplasms (drug therapy, Protein Isoforms (metabolism), Brain (metabolism)

العلاقة: https://scholar.barrowneuro.org/neurobiology/2362Test; https://doi.org/10.1172/jci.insight.167081Test

الإتاحة: https://doi.org/10.1172/jci.insight.167081Test
https://scholar.barrowneuro.org/neurobiology/2362Test

المؤلفون: Andersen, Phillip Alexander Keller, Petrenko, Volodymyr, Rose, Peter Horskjær, Koomen, Melissa, Fischer, Nico, Ghiasi, Seyed Mojtaba, Dahlby, Tina, Dibner, Charna, Mandrup-Poulsen, Thomas

المصدر: ISSN: 1661-6596 ; International Journal of Molecular Sciences, vol. 22, no. 1 (2020) 83.

مصطلحات موضوعية: info:eu-repo/classification/ddc/612, info:eu-repo/classification/ddc/616, ARNTL Transcription Factors/genetics/metabolism, Animals, Cell Line, Tumor, Cells, Cultured, Circadian Rhythm, Female, HEK293 Cells, Histone Deacetylases/metabolism, Humans, Insulin/metabolism, Insulin-Secreting Cells/drug effects/metabolism, Interferon-gamma/metabolism/pharmacology, Male, Mice, Nitric Oxide/metabolism, Proteasome Endopeptidase Complex/metabolism, Reactive Oxygen Species/metabolism

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33374803; https://archive-ouverte.unige.ch/unige:154823Test; unige:154823

الإتاحة: https://doi.org/10.3390/ijms22010083Test
https://archive-ouverte.unige.ch/unige:154823Test

المؤلفون: Ana Katušić-Bojanac, Milvija Plazibat, Marta Himelreich-Perić, Katarina Eck-Raković, Jure Krasić, Nino Sinčić, Gordana Jurić-Lekić, Davor Ježek, Floriana Bulić-Jakuš

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8861

مصطلحات موضوعية: Placenta, Histone Deacetylases, Catalysis, Inorganic Chemistry, Pregnancy, Animals, Humans, Physical and Theoretical Chemistry, valproate, HDACi, neural tissue, ectoplacental cone, embryo, Molecular Biology, Spectroscopy, Placenta / metabolism, Mammals, Valproic Acid / pharmacology, Valproic Acid, Organic Chemistry, Gastrulation, Mammals / metabolism, Acetylation, General Medicine, Histone Deacetylase Inhibitors / pharmacology, Computer Science Applications, Rats, Histone Deacetylase Inhibitors, Histone Deacetylases / metabolism, Female

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94172e33185d6c105d2d22ab302ee8bTest

المؤلفون: Brest, Patrick, Gustafsson, Mattias, Mossberg, Anki, Gustafsson, Lotta, Düringer, Caroline, Hamiche, Ali, Svanborg, Catharina

المصدر: Cancer Research. 67(23):11327-11334

مصطلحات موضوعية: Histone Deacetylases: metabolism, Histones: metabolism, Histone Deacetylases: antagonists & inhibitors, Hela Cells: drug effects, Enzyme Inhibitors: pharmacology, Cyclin-Dependent Kinase Inhibitor p21: metabolism, Chromatin: ultrastructure, Chromatin: metabolism, Chromatin: drug effects, Cell Survival: drug effects, Acetylation: drug effects, Oleic Acids: pharmacology, Lactalbumin: pharmacology, Jurkat Cells: drug effects, Hydroxamic Acids: pharmacology, Medicin och hälsovetenskap, Klinisk medicin, Cancer och onkologi, Medical and Health Sciences, Clinical Medicine, Cancer and Oncology

الوصول الحر: https://lup.lub.lu.se/record/1035674Test
http://www.ncbi.nlm.nih.gov/pubmed/18056459?dopt=AbstractTest
http://dx.doi.org/10.1158/0008-5472.CAN-07-1153Test

المؤلفون: Tasset, Celine, Singh Yadav, Avilash, Sureshkumar, Sridevi, Singh, Rupali, van der Woude, Lennard, Nekrasov, Maxim, Tremethick, David, van Zanten, Martijn, Balasubramanian, Sureshkumar

المساهمون: Sub Molecular Plant Physiology, Molecular Plant Physiology

مصطلحات موضوعية: Acetylation, Arabidopsis/genetics, Arabidopsis Proteins/genetics, Histone Deacetylases/metabolism, Histones/metabolism, Morphogenesis, Mutation, Temperature, Transcription Factors/genetics

وصف الملف: image/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/376701Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/376701Test

المؤلفون: Ronin, C, Costa, DM, Tavares, J, Faria, J, Ciesielski, F, Ciapetti, P, Smith, TK, MacDougall, J, Cordeiro-da-Silva, A, Pemberton, I

المساهمون: Instituto de Investigação e Inovação em Saúde

مصطلحات موضوعية: Binding Site, Crystallography, X-Ray, Drug Design, Group III Histone Deacetylases / chemistry, Group III Histone Deacetylases / metabolism, Humans, Leishmania infantum / metabolismo, Models, Molecular, Peptides / metabolism, Protein Binding, Protein Structure, Secondary, Protozoan Proteins / chemistry, Protozoan Proteins / metabolism

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/EC/FP7/602773/EU; PLoS ONE, vol.13(3):e0193602; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193602Test; https://hdl.handle.net/10216/127391Test

الإتاحة: https://doi.org/10.1371/journal.pone.0193602Test
https://hdl.handle.net/10216/127391Test

المساهمون: College of Medicine, Dept. of Life Science, Kyeongkyu Kim, Kyungjin Boo, Young Suk Yu, Se Kyu Oh, Hyunkyung Kim, Yoon Jeon, Jinhyuk Bhin, Daehee Hwang, Keun Il Kim, Jun-Su Lee, Seung-Soon Im, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Ho Lee, Sungsoon Fang, Sung Hee Baek, Fang, Sungsoon

مصطلحات موضوعية: Animals, Diet, High-Fat, Fatty Liver/genetics, Gene Expression Regulation/genetics, Gene Regulatory Networks, Glucose/metabolism, Histone Deacetylases/metabolism, Homeostasis, Insulin Resistance/genetics, Lipid Metabolism/genetics, Lipogenesis/genetics, Liver/metabolism, Mice, Nuclear Receptor Subfamily 1, Group F, Member 1/genetics, Obesity/genetics, PPAR gamma/antagonists & inhibitors, PPAR gamma/genetics, Promoter Regions, Genetic/genetics

العلاقة: NATURE COMMUNICATIONS; J02293; OAK-2017-03891; https://ir.ymlib.yonsei.ac.kr/handle/22282913/160522Test; T201702567; NATURE COMMUNICATIONS, Vol.8(162) : 1-15, 2017

الإتاحة: https://doi.org/10.1038/s41467-017-00215-1Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160522Test

المساهمون: Others, Severance Hospital, Woo Sun Kwon, Sun Young Rha, Hei-Cheul Jeung, Tae Soo Kim, Hyun Cheol Chung, Kim, Tae Soo, Rha, Sun Young, Chung, Hyun Cheol, Jeung, Hei Cheul

مصطلحات موضوعية: Acetylation/drug effects, Amino Acid Substitution, Antineoplastic Agents, Phytogenic/pharmacology, Antineoplastic Combined Chemotherapy Protocols/pharmacology, BRCA2 Protein/genetics, BRCA2 Protein/metabolism, Breast Neoplasms/drug therapy, Breast Neoplasms/genetics, Breast Neoplasms/metabolism, Cell Line, Tumor, Cell Survival/drug effects, Drug Resistance, Neoplasm/drug effects, Female, Heterozygote, Histone Deacetylase Inhibitors/pharmacology, Histone Deacetylases/chemistry, Histone Deacetylases/metabolism, Humans, Mutation, Neoplasm Proteins/antagonists & inhibitors, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Paclitaxel/pharmacology, Polymorphism, Single Nucleotide, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism

العلاقة: BIOCHEMICAL PHARMACOLOGY; J00283; OAK-2017-03170; https://ir.ymlib.yonsei.ac.kr/handle/22282913/160319Test; https://www.sciencedirect.com/science/article/pii/S0006295217302320Test; T201702086; BIOCHEMICAL PHARMACOLOGY, Vol.138 : 163-173, 2017

الإتاحة: https://doi.org/10.1016/j.bcp.2017.04.015Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160319Test
https://www.sciencedirect.com/science/article/pii/S0006295217302320Test