التفاصيل البيبلوغرافية
العنوان:
Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors
المؤلفون:
Sabrina Dallavalle , Valentina Zuco , Franco Zunino , Loana Musso , Giuseppe Giannini , Alessandra Nurisso , Raffaella Cincinelli , Claudio Pisano , Muriel Cuendet , Loredana Vesci
المصدر:
Bioorganic & Medicinal Chemistry Letters, Vol. 25, No 20 (2015) pp. 4457-4460
سنة النشر:
2015
مصطلحات موضوعية:
Models, Molecular , Stereochemistry , Clinical Biochemistry , Histone Deacetylase 2 , Pharmaceutical Science , Histone Deacetylase 2/antagonists & inhibitors/metabolism , Hydroxamic Acids , Biochemistry , Cell Line , Cell Proliferation/drug effects , Dose-Response Relationship , chemistry.chemical_compound , Structure-Activity Relationship , Models , Cell Line, Tumor , Drug Discovery , Organometallic Compounds , Humans , Molecular Biology , Cell Proliferation , ddc:615 , Hydroxamic acid , Tumor , Dose-Response Relationship, Drug , Molecular Structure , Organic Chemistry , Molecular , Histone Deacetylase Inhibitors , Hydroxamic Acids/chemistry/pharmacology , Zinc , chemistry , Zinc/chemistry/pharmacology , Molecular Medicine , Histone Deacetylase Inhibitors/chemical synthesis/chemistry/pharmacology , Histone deacetylase , Organometallic Compounds/chemical synthesis/chemistry/pharmacology , Drug
الوصف:
A series of alternative Zn-binding groups were explored in the design of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Most of the synthesized compounds were less effective than the parent hydroxamic acid. However, the profile of activity shown by the analog bearing a hydroxyurea head group, makes this derivative promising for further investigation.
اللغة:
English
تدمد:
0960-894X
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63734d3ade9f2d9a83b1d35583bae80cTest https://archive-ouverte.unige.ch/unige:94981Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....63734d3ade9f2d9a83b1d35583bae80c
قاعدة البيانات:
OpenAIRE
