دورية أكاديمية
Food Insecurity Is Associated With Low Tenofovir Diphosphate in Dried Blood Spots in South African Persons With HIV
| العنوان: | Food Insecurity Is Associated With Low Tenofovir Diphosphate in Dried Blood Spots in South African Persons With HIV |
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| المؤلفون: | Hirsh, Molly L, Edwards, Jonathan A, Robichaux, Chad, Brijkumar, Jaysingh, Moosa, Mahomed-Yunus S, Ofotokun, Igho, Johnson, Brent A, Pillay, Selvan, Pillay, Melendhran, Moodley, Pravi, Sun, Yan V, Liu, Chang, Dudgeon, Mathew R, Ordoñez, Claudia, Kuritzkes, Daniel R, Sunpath, Henry, Morrow, Mary, Anderson, Peter L, Ellison, Lucas, Bushman, Lane R, Marconi, Vincent C, Castillo-Mancilla, Jose R |
| المساهمون: | Emory University Center for AIDS Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, [ADReSS] |
| المصدر: | Open Forum Infectious Diseases ; volume 10, issue 7 ; ISSN 2328-8957 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Infectious Diseases, Oncology |
| الوصف: | Background Food insecurity has been linked to suboptimal antiretroviral therapy (ART) adherence in persons with HIV (PWH). This association has not been evaluated using tenofovir diphosphate (TFV-DP) in dried blood spots (DBSs), a biomarker of cumulative ART adherence and exposure. Methods Within a prospective South African cohort of treatment-naive PWH initiating ART, a subset of participants with measured TFV-DP in DBS values was assessed for food insecurity status. Bivariate and multivariate median-based regression analysis compared the association between food insecurity and TFV-DP concentrations in DBSs adjusting for age, sex, ethnicity, medication possession ratio (MPR), and estimated glomerular filtration rate. Results Drug concentrations were available for 285 study participants. Overall, 62 (22%) PWH reported worrying about food insecurity and 44 (15%) reported not having enough food to eat in the last month. The crude median concentrations of TFV-DP in DBSs differed significantly between those who expressed food insecurity worry versus those who did not (599 [interquartile range {IQR}, 417–783] fmol/punch vs 716 [IQR, 453–957] fmol/punch; P = .032). In adjusted median-based regression, those with food insecurity worry had concentrations of TFV-DP that were 155 (95% confidence interval, −275 to −35; P = .012) fmol/punch lower than those who did not report food insecurity worry. Age and MPR remained significantly associated with TFV-DP. Conclusions In this study, food insecurity worry is associated with lower TFV-DP concentrations in South African PWH. This highlights the role of food insecurity as a social determinant of HIV outcomes including ART failure and resistance. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ofid/ofad360 |
| DOI: | 10.1093/ofid/ofad360/50879705/ofad360.pdf |
| الإتاحة: | https://doi.org/10.1093/ofid/ofad360Test https://academic.oup.com/ofid/article-pdf/10/7/ofad360/50899992/ofad360.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.E2D629B0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ofid/ofad360 |
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