دورية أكاديمية
Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease
| العنوان: | Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease |
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| المؤلفون: | Liu, Tengfei, Zhang, Jingwei, Chen, Xiahuan, Feng, Xueru, Fu, Sidney W., McCaffrey, Timothy A., Liu, Meilin |
| المساهمون: | Liu, ML (reprint author), Peking Univ, Dept Geriatr, Hosp 1, 8 Xishiku St, Beijing 100034, Peoples R China., Peking Univ, Dept Geriatr, Hosp 1, Beijing 100034, Peoples R China., George Washington Univ, Sch Med & Hlth Sci, Div Genom Med, Dept Med, Washington, DC 20037 USA., Peking Univ, Dept Geriatr, Hosp 1, 8 Xishiku St, Beijing 100034, Peoples R China. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | GENE |
| سنة النشر: | 2015 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Coronary artery disease (CAD), Aspirin, 11-Dehydrothromboxane B2 (11dhTxB2), Light Transmission Aggregometry (LTA), High-on aspirin platelet reactivity (HAPR), TYPE-2 DIABETES-MELLITUS, THROMBOXANE BIOSYNTHESIS, RESISTANCE, STROKE, RISK, THERAPY, PREVENTION, PREVALENCE, REACTIVITY |
| الوصف: | Aspirin is widely used in the primary and secondary prevention of cardiovascular diseases. The aim of our study was to compare between two established methods of aspirin response, urinary 11-dehydrothromboxane B2 (11dhTX132) and platelet Light Transmission Aggregometry (LTA) assays in elderly Chinese patients with coronary artery disease (CAD), and to investigate the clinical significance of both methods in predicting cardiovascular events. Urinary 11dhTxB2 assay and arachidonic acid-induced (AA, 0.5 mg/ml) platelet aggregation by Light Transmission Aggregometry (LTA) assay were measured to evaluate aspirin responses. High-on aspirin platelet reactivity (HAPR) was defined as urinary 11dhTxB2 > 1500 pg/mg or AA-induced platelet aggregation >= 15.22%-the upper quartile of our enrolled population. The two tests showed a poor correlation for aspirin inhibition (r = 0.063) and a poor agreement in classifying HAPR (kappa = 0.053). With a mean follow-up time of 12 months, cardiovascular events occurred more frequently in HAPR patients who were diagnosed by LTA assay as compared with no-HAPR patients (22.5% versus 10.6%, P = 0.039, OR = 2.45, 95% CI = 1.06-5.63). However, the HAPR status, as determined by urinary 11dTXB2 measurement, did not show a significant correlation with outcomes. (C) 2015 Elsevier B.V. All rights reserved. ; International Science & Technology Cooperation Projects of China [2013DFA30860]; National Science & Technology Pillar Program of China [2012BAI 37B00]; Beijing Huikangyisheng Sci-Tech Co., Ltd. [00020140616003] ; SCI(E) ; PubMed ; ARTICLE ; meilinliu@yahoo.com ; 1 ; 23-27 ; 571 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0378-1119 1879-0038 |
| العلاقة: | GENE.2015,571,(1),23-27.; 1289733; http://hdl.handle.net/20.500.11897/415745Test; WOS:000360420500004 |
| DOI: | 10.1016/j.gene.2015.06.045 |
| الإتاحة: | https://doi.org/20.500.11897/415745Test https://doi.org/10.1016/j.gene.2015.06.045Test https://hdl.handle.net/20.500.11897/415745Test |
| رقم الانضمام: | edsbas.F786BE67 |
| قاعدة البيانات: | BASE |
| تدمد: | 03781119 18790038 |
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| DOI: | 10.1016/j.gene.2015.06.045 |