دورية أكاديمية
A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma
| العنوان: | A prospective evaluation of 18F-FDG and 11C-acetate PET/CT for detection of primary and metastatic hepatocellular carcinoma |
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| المؤلفون: | Park, Joong-Won, Kim, Ji Hoon, Kim, Seok Ki, Kang, Keon Wook, Park, Kyung Woo, Choi, Jun-Il, Lee, Woo Jin, Kim, Chang-Min, Nam, Byung Ho |
| المساهمون: | 박중원, 김지훈, 김석기, 강건욱, 박경우, 최전일, 이우진, 김창민, 남병호 |
| بيانات النشر: | The Society of Nuclear Medicine Inc |
| سنة النشر: | 2008 |
| المجموعة: | Seoul National University: S-Space |
| مصطلحات موضوعية: | Acetates/*diagnostic use, Adult, Carbon/*diagnostic use, Female, Fluorodeoxyglucose F18/*diagnostic use, Humans, Incidence, Korea/epidemiology, Liver Neoplasms/*diagnosis/*mortality, Male, Middle Aged, Positron-Emission Tomography/*statistics & numerical data, Prognosis, Prospective Studies, Radiopharmaceuticals/diagnostic use, Reproducibility of Results, Risk Assessment/methods, Risk Factors, Sensitivity and Specificity, Subtraction Technique/statistics & numerical data, Survival Analysis, Survival Rate, Tomography, X-Ray Computed/*statistics & numerical data, Carcinoma, Hepatocellular/diagnosis/mortality/secondary |
| الوصف: | Because (18)F-FDG PET has insufficient sensitivity for the detection of hepatocellular carcinoma (HCC), (11)C-acetate PET has been proposed as another technique for this use. We prospectively evaluated the value of PET/CT using these 2 tracers for the detection of primary and metastatic HCC. METHODS: One hundred twelve patients (99 with HCC, 13 with cholangiocellular carcinoma) underwent biopsy and (18)F-FDG and (11)C-acetate PET/CT. RESULTS: The overall sensitivities of (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT in the detection of 110 lesions in 90 patients with primary HCC were 60.9%, 75.4%, and 82.7%, respectively. Elevated serum alpha-fetoprotein levels, an advanced tumor stage, portal vein tumor thrombosis, large tumors, and multiple tumors were significantly associated with positive (18)F-FDG PET/CT results. Uptake of (11)C-acetate was associated with large and multiple tumors. For (18)F-FDG, the sensitivities according to tumor size (1-2, 2-5, and >/=5 cm) were 27.2%, 47.8%, and 92.8%, respectively; for (11)C-acetate, these respective values were 31.8%, 78.2%, and 95.2%. (18)F-FDG was more sensitive in the detection of poorly differentiated HCC. Overall survival was lower in patients with (18)F-FDG PET/CT positive for all indexed lesions than in those with FDG negative or partially positive through the entire follow-up period. In analysis based on biopsied lesions, the sensitivity of (18)F-FDG PET/CT was 64.4% for primary HCC and 84.4% for (11)C-acetate PET/CT. The overall sensitivities of (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT for 35 metastatic HCCs were 85.7%, 77.0%, and 85.7%, respectively. There was no significant difference in the sensitivity of tracers according to metastatic tumor size, location, or differentiation. CONCLUSION: The addition of (11)C-acetate to (18)F-FDG PET/CT increases the overall sensitivity for the detection of primary HCC but not for the detection of extrahepatic metastases. (18)F-FDG, (11)C-acetate, and dual-tracer PET/CT have a low sensitivity for the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | J Nucl Med. 2008;49(12):1912-1921; 0161-5505 (Print); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18997056Test; http://jnm.snmjournals.org/cgi/reprint/49/12/1912.pdfTest; https://hdl.handle.net/10371/67811Test |
| DOI: | 10.2967/jnumed.108.055087 |
| الإتاحة: | https://doi.org/10.2967/jnumed.108.055087Test https://hdl.handle.net/10371/67811Test http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18997056Test http://jnm.snmjournals.org/cgi/reprint/49/12/1912.pdfTest |
| رقم الانضمام: | edsbas.A05D7C36 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2967/jnumed.108.055087 |
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