دورية أكاديمية
Development and validation of a disease risk stratification system for patients with haematological malignancies: a retrospective cohort study of the European Society for Blood and Marrow Transplantation registry.
| العنوان: | Development and validation of a disease risk stratification system for patients with haematological malignancies: a retrospective cohort study of the European Society for Blood and Marrow Transplantation registry. |
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| المؤلفون: | Shouval, Roni, Fein, Joshua A., Labopin, Myriam, Cho, Christina, Bazarbachi, Ali, Baron, Frédéric, Bug, Gesine, Ciceri, Fabio, Corbacioglu, Selim, Galimard, Jacques-Emmanuel, Giebel, Sebastian, Gilleece, Maria H., Giralt, Sergio, Jakubowski, Ann, Montoto, Silvia, O'Reilly, Richard J., Papadopoulos, Esperanza B., Peric, Zinaida, Ruggeri, Annalisa, Sanz, Jaime, Sauter, Craig S., Savani, Bipin N., Schmid, Christoph, Spyridonidis, Alexandros, Tamari, Roni, Versluis, Jurjen, Yakoub-Agha, Ibrahim, Perales, Miguel Angel, Mohty, Mohamad, Nagler, Arnon |
| المصدر: | The Lancet Haematology, 8 (3), e205-e215 (2021) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Adult, Cohort Studies, Female, Hematologic Neoplasms/mortality/pathology/therapy, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Prognosis, Proportional Hazards Models, Registries, Retrospective Studies, Risk Factors, Societies, Medical, Survival Rate, Transplantation, Homologous, Human health sciences, Hematology, Sciences de la santé humaine, Hématologie |
| الوصف: | peer reviewed ; BACKGROUND: Diagnosis and remission status at the time of allogeneic haematopoietic stem-cell transplantation (HSCT) are the principal determinants of overall survival following transplantation. We sought to develop a contemporary disease-risk stratification system (DRSS) that accounts for heterogeneous transplantation indications. METHODS: In this retrospective cohort study we included 55 histology and remission status combinations across haematological malignancies, including acute leukaemia, lymphoma, multiple myeloma, and myeloproliferative and myelodysplastic disorders. A total of 47 265 adult patients (aged ≥18 years) who received an allogeneic HSCT between Jan 1, 2012, and Dec 31, 2016, and were reported to the European Society for Blood and Marrow Transplantation registry were included. We divided EBMT patients into derivation (n=25 534), tuning (n=18 365), and geographical validation (n=3366) cohorts. Disease combinations were ranked in a multivariable Cox regression for overall survival in the derivation cohort, cutoff for risk groups were evaluated for the tuning cohort, and the selected system was tested on the geographical validation cohort. An independent single-centre US cohort of 660 patients transplanted between Jan 1, 2010, and Dec 31, 2015 was used to externally validate the results. FINDINGS: The DRSS model stratified patients in the derivation cohort (median follow-up was 2·1 years [IQR 1·0-3·2]) into five risk groups with increasing mortality risk: low risk (reference group), intermediate-1 (hazard ratio for overall survival 1·26 [95% CI 1·17-1·36], p<0·0001), intermediate-2 (1·53 [1·42-1·66], p<0·0001), high (2·03 [1·86-2·22], p<0·0001), and very high (2·87 [2·63-3·13], p<0·0001). DRSS levels were also associated with a stepwise increase in risk across the tuning and geographical validation cohort. In the external validation cohort (median follow-up was 5·7 years [IQR 4·5-7·1]), the DRSS scheme separated patients into 4 risk groups associated with increasing ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2352-3026 |
| العلاقة: | urn:issn:2352-3026; https://orbi.uliege.be/handle/2268/260411Test; info:hdl:2268/260411; https://orbi.uliege.be/bitstream/2268/260411/1/PIIS235230262030394X.pdfTest; scopus-id:2-s2.0-85101139583; info:pmid:33636142 |
| DOI: | 10.1016/S2352-3026(20)30394-X |
| الإتاحة: | https://doi.org/10.1016/S2352-3026Test(20)30394-X https://orbi.uliege.be/handle/2268/260411Test https://orbi.uliege.be/bitstream/2268/260411/1/PIIS235230262030394X.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B102B27 |
| قاعدة البيانات: | BASE |
| تدمد: | 23523026 |
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| DOI: | 10.1016/S2352-3026(20)30394-X |