المؤلفون: Susan A. Charman, Alice Andreu, Helena Barker, Scott Blundell, Anna Campbell, Michael Campbell, Gong Chen, Francis C. K. Chiu, Elly Crighton, Kasiram Katneni, Julia Morizzi, Rahul Patil, Thao Pham, Eileen Ryan, Jessica Saunders, David M. Shackleford, Karen L. White, Lisa Almond, Maurice Dickins, Dennis A. Smith, Joerg J. Moehrle, Jeremy N. Burrows, Nada Abla

المصدر: Malaria Journal, Vol 19, Iss 1, Pp 1-27 (2020)

مصطلحات موضوعية: Physiologically-based pharmacokinetic modelling, Anti-malarial drugs, Ionization constant, Partition coefficient, Biorelevant solubility, Protein binding, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1475-2875Test

الوصول الحر: https://doaj.org/article/e55944d6ff034a1fadacb975357d1421Test

المؤلفون: Daniel L. Priebbenow (1830988), Mitch Mathiew (10426491), Da-Hua Shi (6424643), Jitendra R. Harjani (1998610), Julia G. Beveridge (6424646), Marina Chavchich (35526), Michael D. Edstein (1846186), Sandra Duffy (1451890), Vicky M. Avery (115416), Robert T. Jacobs (349043), Stephen Brand (798331), David M. Shackleford (1294671), Wen Wang (6570), Longjin Zhong (10426493), Given Lee (7610612), Erin Tay (10426495), Helena Barker (3663979), Elly Crighton (3271965), Karen L. White (1304598), Susan A. Charman (1294689), Amanda De Paoli (9034343), Darren J. Creek (167726), Jonathan B. Baell (115410)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Neuroscience, Pharmacology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, stability, antimalarial bis-triazines, Plasmodium falciparum parasites, Peters 4- day test, fast-killing profile, triazine 23, SAR, mouse liver microsomes, ED 50 value, triazine derivatives, antimalarial compounds, disubstituted triazine dimer 23, pharmacokinetic properties

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_of_Potent_and_Fast-Acting_Antimalarial_Bis-1_2_4-triazines/14291413Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00044.s001Test

المؤلفون: Pradipsinh K. Rathod, Margaret A. Phillips, Michael J. Palmer, Sreekanth Kokkonda, Farah El Mazouni, John H. White, David Waterson, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Maria Santos Martinez-Martinez, Helena Barker, Leticia Huertas-Valentin, Jenna McLaren, Santiago Ferrer, Jeremy N. Burrows, Shatrughan P Shahi, Karen L. White, Maria Jose Lafuente-Monasterio, Dave Matthews, Gong Chen, Francis C. K. Chiu, David M. Shackleford, Elly Crighton, Kasiram Katneni, Xiaoyi Deng, Sergio Wittlin, Diana R. Tomchick, Susan A. Charman, Rajesh Chittimalla

المصدر: J Med Chem

مصطلحات موضوعية: Male, Oxidoreductases Acting on CH-CH Group Donors, Plasmodium falciparum, Plasmodium vivax, Population, Dihydroorotate Dehydrogenase, Mice, SCID, Drug resistance, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Article, Antimalarials, Structure-Activity Relationship, 03 medical and health sciences, Dogs, Parasitic Sensitivity Tests, Cell Line, Tumor, parasitic diseases, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Pyrroles, Enzyme Inhibitors, Malaria, Falciparum, education, 030304 developmental biology, Dihydroorotate Dehydrogenase Inhibitor, 0303 health sciences, education.field_of_study, Molecular Structure, biology, Chemistry, biology.organism_classification, medicine.disease, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Microsomes, Liver, Dihydroorotate dehydrogenase, Molecular Medicine, Female, Malaria, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c8bca2acecd67955624d5564e79816Test
https://doi.org/10.1021/acs.jmedchem.0c00311Test

المؤلفون: Helena Barker, Amanda De Paoli, Erin Tay, Given Lee, Sandra Duffy, Susan A. Charman, Robert T. Jacobs, Jitendra R. Harjani, Longjin Zhong, Marina Chavchich, Wen Wang, Da Hua Shi, Mitch Mathiew, Stephen Brand, Vicky M. Avery, Michael D. Edstein, Jonathan B. Baell, Darren J. Creek, Daniel L. Priebbenow, David M. Shackleford, Julia G. Beveridge, Karen L. White, Elly Crighton

المصدر: Journal of medicinal chemistry. 64(7)

مصطلحات موضوعية: Male, Plasmodium berghei, Plasmodium falciparum, Parasitemia, Mice, SCID, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Structure-Activity Relationship, Pharmacokinetics, Parasitic Sensitivity Tests, Mice, Inbred NOD, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, 030304 developmental biology, Triazine, 0303 health sciences, biology, Molecular Structure, Triazines, biology.organism_classification, medicine.disease, In vitro, 0104 chemical sciences, Malaria, 010404 medicinal & biomolecular chemistry, chemistry, Microsome, Microsomes, Liver, Molecular Medicine, Female, Caco-2 Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f1d1159435727870af2d12001515a2Test
https://pubmed.ncbi.nlm.nih.gov/33759519Test

المؤلفون: Francis C. K. Chiu, David M. Shackleford, Karen L. White, Sergio Wittlin, Sriraghavan Kamaraj, Qingjie Zhao, Petros Papastogiannidis, Jonathan L. Vennerstrom, Eileen Ryan, Heinrich Urwyler, Christian Scheurer, Christopher D. Hein, Manickam Dhanasekaran, Vivek J. Bulbule, Lin Zhou, Helena Barker, Yuxiang Dong, Julia Morizzi, Susan A. Charman, Jacques Chollet, Xiaofang Wang, William N. Charman, Hugues Matile, Yuanqing Tang

المصدر: Journal of Medicinal Chemistry. 60:2654-2668

مصطلحات موضوعية: Male, 0301 basic medicine, Plasmodium berghei, Stereochemistry, Plasmodium falciparum, Adamantane, Artefenomel, 01 natural sciences, Antimalarials, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Ozonide, Structure–activity relationship, Arterolane, 010405 organic chemistry, Metabolic stability, Malaria, Peroxides, Rats, 0104 chemical sciences, 030104 developmental biology, chemistry, Molecular Medicine, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5d0e4db318313ac45676fe7371d64dTest
https://doi.org/10.1021/acs.jmedchem.6b01586Test