المؤلفون: Voisin, Sarah, Seale, Kirsten, Jacques, Macsue, Landen, Shanie, Harvey, Nicholas R., Haupt, Larisa M., Griffiths, Lyn R., Ashton, Kevin J., Coffey, Vernon G., Thompson, Jamie-Lee M., Doering, Thomas M., Lindholm, Malene E., Walsh, Colum, Davison, Gareth, Irwin, Rachelle, McBride, Catherine, Hansson, Ola, Asplund, Olof, Heikkinen, Aino E., Piirilä, Päivi, Pietiläinen, Kirsi H., Ollikainen, Miina, Blocquiaux, Sara, Thomis, Martine, Dawn, Coletta K., Sharples, Adam P., Eynon, Nir

المساهمون: Institute for Molecular Medicine Finland, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, Clinicum, HUS Abdominal Center, Department of Medicine, Research Programs Unit, CAMM - Research Program for Clinical and Molecular Metabolism, Endokrinologian yksikkö

مصطلحات موضوعية: DNA methylation, Aging, Cardiorespiratory fitness, Exercise training, Human skeletal muscle, mRNA expression, Meta-analysis, 1182 Biochemistry, cell and molecular biology, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: National Health and Medical Research Council, Grant/Award Number: APP1140644 and APP11577321; Sarah Voisin's National Health & Medical Research Council, Grant/Award Number: APP11577321; Nir Eynon's NHMRC Career Development Fellowship, Grant/Award Number: APP1140644; Voisin , S , Seale , K , Jacques , M , Landen , S , Harvey , N R , Haupt , L M , Griffiths , L R , Ashton , K J , Coffey , V G , Thompson , J-L M , Doering , T M , Lindholm , M E , Walsh , C , Davison , G , Irwin , R , McBride , C , Hansson , O , Asplund , O , Heikkinen , A E , Piirilä , P , Pietiläinen , K H , Ollikainen , M , Blocquiaux , S , Thomis , M , Dawn , C K , Sharples , A P & Eynon , N 2024 , ' Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle ' , Aging Cell , vol. 23 , no. 1 , e13859 . https://doi.org/10.1111/acel.13859Test; ORCID: /0000-0003-3661-7400/work/151222496; ORCID: /0000-0002-2535-4409/work/151225450; http://hdl.handle.net/10138/569914Test; 0ab17f90-2a17-4273-a893-2d8d906802a6; 000981320000001

الإتاحة: http://hdl.handle.net/10138/569914Test

المؤلفون: Lapatto, Helena A. K., Kuusela, Minna, Heikkinen, Aino, Muniandy, Maheswary, van der Kolk, Birgitta W., Gopalakrishnan, Swetha, Pöllänen, Noora, Sandvik, Martin, Schmidt, Mark S., Heinonen, Sini, Saari, Sina, Kuula, Juho, Hakkarainen, Antti, Tampio, Janne, Saarinen, Tuure, Taskinen, Marja-Riitta, Lundbom, Nina, Groop, Per-Henrik, Tiirola, Marja, Katajisto, Pekka, Lehtonen, Marko, Brenner, Charles, Kaprio, Jaakko, Pekkala, Satu, Ollikainen, Miina, Pietiläinen, Kirsi H., Pirinen, Eija

المساهمون: Centre of Excellence in Stem Cell Metabolism, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Molecular and Integrative Biosciences Research Programme, Institute of Biotechnology, HUS Medical Imaging Center, Clinicum, HUS Abdominal Center, II kirurgian klinikka, Marja-Riitta Taskinen Research Group, Research Programs Unit, Department of Medicine, Per Henrik Groop / Principal Investigator, Medicum, Nefrologian yksikkö, Department of Biochemistry and Developmental Biology, Eija Pirinen / Principal Investigator

مصطلحات موضوعية: High-fat diet, Dna methylation, Skeletal-muscle, Adipose-tissue, Faecalibacterium-prausnitzii, Nad(+), Metabolism, Niacin, Liver, Supplementation, 3111 Biomedicine, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: Lapatto , H A K , Kuusela , M , Heikkinen , A , Muniandy , M , van der Kolk , B W , Gopalakrishnan , S , Pöllänen , N , Sandvik , M , Schmidt , M S , Heinonen , S , Saari , S , Kuula , J , Hakkarainen , A , Tampio , J , Saarinen , T , Taskinen , M-R , Lundbom , N , Groop , P-H , Tiirola , M , Katajisto , P , Lehtonen , M , Brenner , C , Kaprio , J , Pekkala , S , Ollikainen , M , Pietiläinen , K H & Pirinen , E 2023 , ' Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study ' , Science Advances , vol. 9 , no. 2 , eadd5163 . https://doi.org/10.1126/sciadv.add5163Test; ORCID: /0000-0002-6229-3588/work/127503841; ORCID: /0000-0003-3661-7400/work/127504093; ORCID: /0000-0002-5793-9196/work/127508370; ORCID: /0000-0001-8608-541X/work/127508859; ORCID: /0000-0003-2013-4420/work/128032715; ORCID: /0000-0002-3295-1260/work/133998104; 714d22d2-aa5a-4407-aee4-456b3290c766; http://hdl.handle.net/10138/353809Test; 000911464300022

الإتاحة: http://hdl.handle.net/10138/353809Test

المؤلفون: Kankaanpää, Anna, Tolvanen, Asko, Saikkonen, Pirkko, Heikkinen, Aino, Laakkonen, Eija K., Kaprio, Jaakko, Ollikainen, Miina, Sillanpää, Elina

المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Department of Public Health

مصطلحات موضوعية: 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: Kankaanpää , A , Tolvanen , A , Saikkonen , P , Heikkinen , A , Laakkonen , E K , Kaprio , J , Ollikainen , M & Sillanpää , E 2022 , ' Do Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? A Cross-Sectional Twin Study ' , Journals of Gerontology. Series A: Biological Sciences and Medical Sciences , vol. 77 , no. 9 , pp. 1898–1906 . https://doi.org/10.1093/gerona/glab337Test; Bibtex: 10.1093/gerona/glab337; ORCID: /0000-0003-3661-7400/work/127504091; 2cb3de3d-1ae5-4f33-b7ed-e86994ac86ed; http://hdl.handle.net/10138/353359Test; 000790074400001

الإتاحة: http://hdl.handle.net/10138/353359Test

المؤلفون: Sehovic, Emir, Zellers, Stephanie M., Youssef, Markus K., Heikkinen, Aino, Kaprio, Jaakko, Ollikainen, Miina

المساهمون: Institute for Molecular Medicine Finland

مصطلحات موضوعية: DNA methylation, Heritability, meQTL, Puberty, Twins, Young adults, 1184 Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: We express our gratitude to Teemu Palviainen for his assistance with data management and curation and to Mikaela Hukkanen for her advice and discussions on IPA. We also thank Dr. Giovanna Chiorino for her invaluable advice and insightful discussions. Finally, we thank the FIMM Technology Centre supported by HiLIFE and Biocenter Finland for DNA methylation data generation services, as well as all FinnTwin12 and FinnTwin16 participants and their families included in this study. Open Access funding provided by University of Helsinki (including Helsinki University Central Hospital). This work was supported by the European Union’s Horizon 2020 Research and Innovation Programme, Marie Skłodowska-Curie (grant number 859860). Data collection in the FinnTwin12 and FinnTwin16 cohorts have been supported by the Wellcome Trust Sanger Institute, the Broad Institute, ENGAGE – European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007, grant agreement number 201413, National Institute of Alcohol Abuse and Alcoholism (grants AA-12502, AA-00145, and AA-09203 to R J Rose; AA15416 and K02AA018755 to D M Dick; R01AA015416 to Jessica Salvatore), the Academy of Finland (grants 100499, 205585, 118555, 141054, 264146, 308248 to JK, and grants 328685, 307339, 297908 and 251316 to MO, and the Centre of Excellence in Complex Disease Genetics grants 312073, 336823, and 352792 to JK), and Sigrid Juselius Foundation (to MO).; Sehovic , E , Zellers , S M , Youssef , M K , Heikkinen , A , Kaprio , J & Ollikainen , M 2023 , ' DNA methylation sites in early adulthood characterised by pubertal timing and development : a twin study ' , Clinical epigenetics , vol. 15 , no. 1 , 181 . https://doi.org/10.1186/s13148-023-01594-7Test; ORCID: /0000-0003-3661-7400/work/147915804; ORCID: /0000-0001-8927-3483/work/147919206; 85176250684; 440faad8-91a5-4ad9-8d10-e671e99a8fe3; http://hdl.handle.net/10138/567963Test

الإتاحة: http://hdl.handle.net/10138/567963Test

المؤلفون: Voisin, Sarah, Seale, Kirsten, Jacques, Macsue, Landen, Shanie, Harvey, Nicholas R, Haupt, Larisa M, Griffiths, Lyn R, Ashton, Kevin J, Coffey, Vernon G, Thompson, Jamie-Lee M, Doering, Thomas M, Lindholm, Malene E, Walsh, Colum, Davison, Gareth, Irwin, Rachelle, McBride, Catherine, Hansson, Ola, Asplund, Olof, Heikkinen, Aino E, Piirilä, Päivi, Pietiläinen, Kirsi H, Ollikainen, Miina, Blocquiaux, Sara, Thomis, Martine, Dawn, Coletta K, Sharples, Adam P, Eynon, Nir

المصدر: Voisin , S , Seale , K , Jacques , M , Landen , S , Harvey , N R , Haupt , L M , Griffiths , L R , Ashton , K J , Coffey , V G , Thompson , J-L M , Doering , T M , Lindholm , M E , Walsh , C , Davison , G , Irwin , R , McBride , C , Hansson , O , Asplund , O , Heikkinen , A E , Piirilä , P , Pietiläinen , K H , Ollikainen , M , Blocquiaux ....

العلاقة: https://research.bond.edu.au/en/publications/75e8a464-112d-4f7f-a1ca-e7c6553c7131Test

الإتاحة: https://doi.org/10.1111/acel.13859Test
https://research.bond.edu.au/en/publications/75e8a464-112d-4f7f-a1ca-e7c6553c7131Test
http://www.scopus.com/inward/record.url?scp=85157977495&partnerID=8YFLogxKTest

المؤلفون: Marttila, Saara, Tamminen, Hely, Rajić, Sonja, Mishra, Pashupati P, Lehtimäki, Terho, Raitakari, Olli, Kähönen, Mika, Kananen, Laura, Jylhävä, Juulia, Hägg, Sara, Delerue, Thomas, Peters, Annette, Waldenberger, Melanie, Kleber, Marcus E, März, Winfried, Luoto, Riitta, Raitanen, Jani, Sillanpää, Elina, Laakkonen, Eija K, Heikkinen, Aino, Ollikainen, Miina, Raitoharju, Emma

المساهمون: Tampere University, Clinical Medicine, Department of Clinical Chemistry, Department of Clinical Physiology and Nuclear Medicine, Health Sciences

مصطلحات موضوعية: 217 Medical engineering, 3111 Biomedicine

وصف الملف: fulltext

العلاقة: 18; 14; ORCID: /0000-0003-3071-3784/work/126321698; ORCID: /0000-0003-0250-4491/work/126322456; ORCID: /0000-0001-7674-0978/work/126322629; ORCID: /0000-0002-2555-4427/work/127420253; ORCID: /0000-0002-4510-7341/work/126750764; ORCID: /0000-0002-7023-8706/work/154735468; https://trepo.tuni.fi/handle/10024/144956Test; URN:NBN:fi:tuni-202212099023

الإتاحة: https://doi.org/10.2217/epi-2022-0228Test
https://trepo.tuni.fi/handle/10024/144956Test

المؤلفون: Kankaanpää, Anna, Tolvanen, Asko, Heikkinen, Aino, Kaprio, Jaakko, Ollikainen, Miina, Sillanpää, Elina

المساهمون: Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, University of Helsinki

مصطلحات موضوعية: DNA methylation, Lifespan, Adolescence, Biological age, Epigenetic aging, Lifestyle, Pace of aging, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: Kankaanpää , A , Tolvanen , A , Heikkinen , A , Kaprio , J , Ollikainen , M & Sillanpää , E 2022 , ' The role of adolescent lifestyle habits in biological aging : A prospective twin study ' , eLife , vol. 11 , e80729 . https://doi.org/10.7554/eLife.80729Test; ORCID: /0000-0003-3661-7400/work/124840151; 84abce17-e4f5-4360-82aa-d2eddc65afad; http://hdl.handle.net/10138/351618Test; 000882608000001

الإتاحة: http://hdl.handle.net/10138/351618Test

المؤلفون: Bode, Hannes F., Heikkinen, Aino, Lundgren, Sara, Kaprio, Jaakko, Ollikainen, Miina

المساهمون: Helsinki Institute of Life Science HiLIFE, Joint Activities, Institute for Molecular Medicine Finland, Epigenetics of Complex Diseases and Traits, Faculty Common Matters (Faculty of Biology and Environmental Sciences)

مصطلحات موضوعية: Epigenetic age acceleration, cancer-discordant twin pairs, breast cancer, BREAST-CANCER, EPIGENETIC AGE, LIFE EVENTS, RISK, STRESS, ACCELERATION, BIOMARKERS, MORTALITY, WOMEN, 3122 Cancers

وصف الملف: application/pdf

العلاقة: This research was funded by the European Union's Horizon 2020 Research and Innovation Programme, Marie SklodowskaCurie (JK, grant number 859860). This project has received further funding from the Academy of Finland (MO, grant numbers 297908, 328685 & JK, grant 336823) and the Sigrid Juselius Foundation (MO and JK).; Bode , H F , Heikkinen , A , Lundgren , S , Kaprio , J & Ollikainen , M 2022 , ' Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer ' , Twin Research and Human Genetics , vol. 25 , 1832427422000329 , pp. 171-179 . https://doi.org/10.1017/thg.2022.32Test; ORCID: /0000-0003-3661-7400/work/123554684; d36b004c-2864-44f0-868e-2a35ecb1e74f; http://hdl.handle.net/10138/350963Test; 000851328300001

الإتاحة: http://hdl.handle.net/10138/350963Test

المؤلفون: Sofieva, Svetlana, Asmi, Eija, Atanasova, Nina S., Heikkinen, Aino E., Vidal, Emeline, Duplissy, Jonathan, Romantschuk, Martin, Kouznetsov, Rostislav, Kukkonen, Jaakko, Bamford, Dennis H., Hyvärinen, Antti-Pekka, Sofiev, Mikhail

المساهمون: Molecular and Integrative Biosciences Research Programme, Aerovirology Research Group, Department of Microbiology, Helsinki Institute of Life Science HiLIFE, Joint Activities, Institute for Molecular Medicine Finland, Helsinki Institute of Physics, Institute for Atmospheric and Earth System Research (INAR), Polar and arctic atmospheric research (PANDA), Ecosystems and Environment Research Programme, Biosciences, Helsinki Institute of Sustainability Science (HELSUS), Martin Romantschuk / Principal Investigator, Structure of the Viral Universe

مصطلحات موضوعية: SEA-SPRAY AEROSOL, PRIMARY MARINE AEROSOL, SODIUM-CHLORIDE, SURFACE-TENSION, SALT AEROSOL, FILM DROPS, OCEAN, ENRICHMENT, JET, PARTICLES, 1172 Environmental sciences

وصف الملف: application/pdf

العلاقة: This research has been supported by the Academy of Finland (grant nos. 309570, 337552, and 310372), the Academy of Finland project grant (grant no. 479507 (DASI) and grant no. 199997 (special funding for research on COVID-19 epidemic)), and the Horizon 2020 (EMERGE (grant no. 874990)).; Sofieva , S , Asmi , E , Atanasova , N S , Heikkinen , A E , Vidal , E , Duplissy , J , Romantschuk , M , Kouznetsov , R , Kukkonen , J , Bamford , D H , Hyvärinen , A-P & Sofiev , M 2022 , ' Effects of temperature and salinity on bubble-bursting aerosol formation simulated with a bubble-generating chamber ' , Atmospheric Measurement Techniques , vol. 15 , no. 20 , pp. 6201-6219 . https://doi.org/10.5194/amt-15-6201-2022Test; ORCID: /0000-0003-1120-7405/work/122636696; ORCID: /0000-0002-6438-8118/work/122637156; 85141986400; 13a7a6d9-f451-4830-af7c-f157f8ed60ac; http://hdl.handle.net/10138/350645Test; 000872151000001

الإتاحة: http://hdl.handle.net/10138/350645Test

المؤلفون: Kankaanpää, Anna, Tolvanen, Asko, Saikkonen, Pirkko, Heikkinen, Aino, Laakkonen, Eija K, Kaprio, Jaakko, Ollikainen, Miina, Sillanpää, Elina

مصطلحات موضوعية: DNA methylation, sex gap, lifestyle, lifespan, biological age, sukupuolierot, elinikä, DNA-metylaatio, ikääntyminen, epigenetiikka, elintavat

وصف الملف: application/pdf; 1898-1906; fulltext

العلاقة: Journals of Gerontology Series A : Biological Sciences and Medical Sciences; 77; 202100426; Juho Vainio Foundation; Juho Vainion Säätiö; Kankaanpää, A., Tolvanen, A., Saikkonen, P., Heikkinen, A., Laakkonen, E. K., Kaprio, J., Ollikainen, M., & Sillanpää, E. (2022). Do Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? : A Cross-Sectional Twin Study. Journals of Gerontology Series A : Biological Sciences and Medical Sciences , 77 (9), 1898-1906. https://doi.org/10.1093/gerona/glab337Test; CONVID_101840729; URN:NBN:fi:jyu-202208254362; http://urn.fi/URN:NBN:fi:jyu-202208254362Test

الإتاحة: http://urn.fi/URN:NBN:fi:jyu-202208254362Test