دورية أكاديمية
Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment
| العنوان: | Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment |
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| المؤلفون: | Wang, Dongdong, He, Isabel Wenjia, Liu, Jiawei, Jana, Deblin, Wu, Yinglong, Zhang, Xiaodong, Qian, Cheng, Guo, Yi, Chen, Xiaokai, Bindra, Anivind Kaur, Zhao, Yanli |
| المساهمون: | School of Physical and Mathematical Sciences |
| سنة النشر: | 2021 |
| المجموعة: | DR-NTU (Digital Repository at Nanyang Technological University, Singapore) |
| مصطلحات موضوعية: | Science::Chemistry, Artesunate, Metal–Organic Framework |
| الوصف: | Clinical translation of artesunate (ATS) as a potent antitumor drug has been obstructed by its rapid degradation and low bioavailability. Herein, we report the development of ATS nanomedicine through the self-assembly with Mn[Co(CN)6]2/31/3 metal-organic frameworks (MOFs) having hidden missing linkers. The defects originated from the missing linkers play a key role in increasing the biological stability and tumor accumulation of ATS. Chlorin e6 (Ce6) and ATS can be co-loaded into MOFs for a synergistic antitumor efficacy. In the presence of intracellular HCO3-, Mn2+ acts as an efficient catalyst to promote the bicarbonate-activated H2O2 system and induce oxidative death to cancer cells based on ATS with an endoperoxide bridge. The released [CoIII(CN)6] linker undergoes a redox reaction with intracellular glutathione to prevent the scavenging ability of reactive oxygen species, contributing to synergistic chemodynamic therapy of ATS and photodynamic therapy of Ce6. Thus, defect-engineered MOFs with hidden missing linkers hold great promises in advancing the practical uses of ATS as an antitumor medicine. ; Agency for Science, Technology and Research (A*STAR) ; National Research Foundation (NRF) ; Submitted/Accepted version ; This research is supported by the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081) and the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1433-7851 |
| العلاقة: | A20E5c0081; NRF-NRFI2018-03; Angewandte Chemie International Edition; Wang, D., He, I. W., Liu, J., Jana, D., Wu, Y., Zhang, X., Qian, C., Guo, Y., Chen, X., Bindra, A. K. & Zhao, Y. (2021). Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angewandte Chemie International Edition, 60(50), 26254-26259. https://dx.doi.org/10.1002/anie.202112128Test; https://hdl.handle.net/10356/155942Test; 50; 60; 26254; 26259 |
| DOI: | 10.1002/anie.202112128 |
| الإتاحة: | https://doi.org/10.1002/anie.202112128Test https://hdl.handle.net/10356/155942Test |
| حقوق: | This is the peer reviewed version of the following article: Wang, D., He, I. W., Liu, J., Jana, D., Wu, Y., Zhang, X., Qian, C., Guo, Y., Chen, X., Bindra, A. K. & Zhao, Y. (2021). Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment. Angewandte Chemie International Edition, 60(50), 26254-26259, which has been published in final form at https://doi.org/10.1002/anie.202112128Test. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| رقم الانضمام: | edsbas.AAD30260 |
| قاعدة البيانات: | BASE |
| تدمد: | 14337851 |
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| DOI: | 10.1002/anie.202112128 |