التفاصيل البيبلوغرافية
| العنوان: |
Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. |
| المؤلفون: |
De, Sanctis G, Singer, J B, Jiao, A, Yandava, C N, Lee, Y H, Haynes, T C, Lander, E S, Beier, D R, Drazen, J M |
| المصدر: |
Faculty Research 1990 - 1999 |
| بيانات النشر: |
The Mouseion at the JAXlibrary |
| سنة النشر: |
1999 |
| المجموعة: |
The Jackson Laboratory: The Mouseion at the JAXlibrary |
| مصطلحات موضوعية: |
Asthma, Bronchial-Hyperreactivity, Bronchial-Provocation-Tests, Bronchoconstrictor-Agents, Chromosome-Mapping, Chromosomes, Genotype, Linkage-(Genetics), Male, Methacholine-Chloride, Mice, Mice-Inbred-A, Mice-Inbred-C3H, Quantitative-Trait, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S |
| الوصف: |
Quantitative trait locus (QTL) mapping was used to identify chromosomal regions contributing to airway hyperresponsiveness in mice. Airway responsiveness to methacholine was measured in A/J and C3H/HeJ parental strains as well as in progeny derived from crosses between these strains. QTL mapping of backcross [(A/J x C3H/HeJ) x C3H/HeJ] progeny (n = 137-227 informative mice for markers tested) revealed two significant linkages to loci on chromosomes 6 and 7. The QTL on chromosome 6 confirms the previous report by others of a linkage in this region in the same genetic backgrounds; the second QTL, on chromosome 7, represents a novel locus. In addition, we obtained suggestive evidence for linkage (logarithm of odds ratio = 1.7) on chromosome 17, which lies in the same region previously identified in a cross between A/J and C57BL/6J mice. Airway responsiveness in a cross between A/J and C3H/HeJ mice is under the control of at least two major genetic loci, with evidence for a third locus that has been previously implicated in an A/J and C57BL/6J cross; this indicates that multiple genetic factors control the expression of this phenotype. |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
https://mouseion.jax.org/stfb1990_1999/1348Test |
| الإتاحة: |
https://mouseion.jax.org/stfb1990_1999/1348Test |
| رقم الانضمام: |
edsbas.CF35184F |
| قاعدة البيانات: |
BASE |
