المؤلفون: Shisha, Tamas, Posch, Maximilian G., Lehmann, Jeanette, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard, Gergely, Peter

المساهمون: Novartis

المصدر: European Journal of Drug Metabolism and Pharmacokinetics ; volume 48, issue 5, page 553-566 ; ISSN 0378-7966 2107-0180

مصطلحات موضوعية: Pharmacology (medical), Pharmacology

الإتاحة: https://doi.org/10.1007/s13318-023-00847-3Test

المؤلفون: Hawtin, Stuart, André, Cédric, Collignon-Zipfel, Géraldine, Appenzeller, Simone, Bannert, Bettina, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Brunner, Hermine I., Ceci, Melanie, Deane, Jonathan, Feifel, Roland, Ferrero, Enrico, Kyburz, Diego, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Michellys, Pierre, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, Rush, James S., Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas, Junt, Tobias

المساهمون: Novartis

المصدر: Cell Reports Medicine ; volume 4, issue 5, page 101036 ; ISSN 2666-3791

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.xcrm.2023.101036Test
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/plainTest

المؤلفون: Hawtin, Stuart R, Andre, Cedric, Caballero, Valerie, McMichael, Katriona, Pfister, Sabina, Appenzeller, Simone, Watts, Allen, Rush, James, Brunner, Hermine I

المصدر: Abstracts

الإتاحة: https://doi.org/10.1136/lupus-2019-lsm.172Test

المؤلفون: Shisha, Tamas, Posch, Maximilian G, Jeanette, Lehmann, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard, Gergely, Peter

العلاقة: Shisha, Tamas, Posch, Maximilian G, Jeanette, Lehmann, Feifel, Roland, Junt, Tobias, Hawtin, Stuart, Schuemann, Jens, Avrameas, Alexandre, Danekula, Rambabu, Misiolek, Patrycja, Siegel, Richard and Gergely, Peter (2023) First-in-human study of safety, pharmacokinetics, and pharmacodynamics of MHV370, a dual inhibitor of Toll-like receptors 7 and 8, in healthy adults. European Journal of Drug Metabolism and Pharmacokinetics, 1 (1). pp. 1-14. ISSN 21070180

الإتاحة: https://doi.org/10.1007/s13318-023-00847-3Test
https://oak.novartis.com/49986Test/

المؤلفون: Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi, Zink, Florence, Zipfel, Géraldine, Hawtin, Stuart, Junt, Tobias, Michellys, Pierre-Yves

المساهمون: Novartis

المصدر: ACS Medicinal Chemistry Letters ; volume 14, issue 8, page 1054-1062 ; ISSN 1948-5875 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00136Test

المؤلفون: Kearns, Jeffrey D., Wassmann, Paul, Olgac, Ufuk, Fichter, Marie, Christen, Brigitte, Rubic-Schneider, Tina, Koepke, Stephan, Cochin de Billy, Benjamin, Ledieu, David, Andre, Cedric, Hawtin, Stuart, Fischer, Benoit, Moretti, Francesca, Hug, Christian, Bepperling, Alexander, Brannetti, Barbara, Mendez-Garcia, Celia, Littlewood-Evans, Amanda, Clemens, Andreas, Grosskreutz, Cynthia L., Mehan, Pawan, Schmouder, Robert L., Sasseville, Vito, Brees, Dominique, Karle, Anette C.

المصدر: Science Translational Medicine ; volume 15, issue 681 ; ISSN 1946-6234 1946-6242

الإتاحة: https://doi.org/10.1126/scitranslmed.abq5068Test

المؤلفون: Ferrero, Enrico, Hawtin, Stuart, Raulf, Friedrich, Junt, Tobias

العلاقة: https://zenodo.org/record/7573856Test; https://doi.org/10.5281/zenodo.7573856Test; oai:zenodo.org:7573856

الإتاحة: https://doi.org/10.5281/zenodo.7573856Test
https://doi.org/10.5281/zenodo.7573855Test
https://zenodo.org/record/7573856Test

المؤلفون: Hoyler, Thomas, Bannert, Bettina, Beck, Damian, Boulay, Thomas, Buffet, David, Caesar, Nadja, Calzascia, Thomas, Dawson King, Janet, Kyburz, Diego, Hennze, Robert, Huppertz, Christine, Littlewood-Evans, Amanda, Loetscher, Pius, Mertz, Kirsten D., Niwa, Satoru, Robert, Gautier, Rush, James, Sarret, Sophie, Stein, Thomas, Touil, Ismahane, Wieczorek, Grazyna, Collignon Zipfel, Geraldine, Hawtin, Stuart, Junt, Tobias

العلاقة: Hoyler, Thomas, Bannert, Bettina, Beck, Damian, Boulay, Thomas, Buffet, David, Caesar, Nadja, Calzascia, Thomas, Dawson King, Janet, Kyburz, Diego, Hennze, Robert, Huppertz, Christine, Littlewood-Evans, Amanda, Loetscher, Pius, Mertz, Kirsten D., Niwa, Satoru, Robert, Gautier, Rush, James, Sarret, Sophie, Stein, Thomas, Touil, Ismahane, Wieczorek, Grazyna, Collignon Zipfel, Geraldine, Hawtin, Stuart and Junt, Tobias (2022) Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants. JCI insight, 7 (13). ISSN 2379-3708

الإتاحة: https://doi.org/10.1172/jci.insight.149825Test
https://oak.novartis.com/47183Test/
https://insight.jci.orgTest/

المؤلفون: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland, Knoepfel, Thomas

العلاقة: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland and Knoepfel, Thomas (2022) Structure-based optimization of a fragment like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00696Test
https://oak.novartis.com/46530Test/

المؤلفون: Alper, Phillip, Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Geraldine, Gordon, William, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, Mckeever, Una, Michellys, Pierre, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James, Syka, Peter, Zhang, Yi, Zhu, Xuefeng

العلاقة: Alper, Phillip, Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Geraldine, Gordon, William, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, Mckeever, Una, Michellys, Pierre, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James, Syka, Peter, Zhang, Yi and Zhu, Xuefeng (2020) Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorganic and Medicinal Chemistry Letters, 30 (17). p. 127366. ISSN 14643405

الإتاحة: https://doi.org/10.1016/j.bmcl.2020.127366Test
https://oak.novartis.com/42543Test/
https://reader.elsevier.com/reader/sd/pii/S0960894X20304777?token=64ACE614744B89DB15C45049D71E6C1FEF8E0DBC0EE7CB21920A18D2A92618723FD2A453DAA07CF11C32FEA6E1EEDD5ETest