نتائج البحث - "Hardcastle, Ian R."

1

دورية أكاديمية

Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Chemical Tool

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/185363/3/acs.jmedchem.1c01756.pdfTest; Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren et al. (23 more authors) (2022) Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Chemical Tool. JOURNAL OF MEDICINAL CHEMISTRY. pp. 6513-6540. ISSN 0022-2623

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01756Test
https://eprints.whiterose.ac.uk/185363Test/
https://eprints.whiterose.ac.uk/185363/3/acs.jmedchem.1c01756.pdfTest

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2

دورية أكاديمية

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions

المؤلفون: Davison, Gemma, Martin, Mathew P., Turberville, Shannon, Dormen, Selma, Heath, Richard, Heptinstall, Amy B., Lawson, Marie, Miller, Duncan C., Ng, Yi Min, Sanderson, James N., Hope, Ian, Wood, Daniel J., Cano, Céline, Endicott, Jane A., Hardcastle, Ian R., Noble, Martin E. M., Waring, Michael J.

المساهمون: Medical Research Council, Newcastle University, Cancer Research UK

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 22, page 15416-15432 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.2c01357Test

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3

دورية أكاديمية

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase

المؤلفون: Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline

المساهمون: Cancer Research UK

المصدر: RSC Medicinal Chemistry ; volume 11, issue 6, page 707-731 ; ISSN 2632-8682

الإتاحة: https://doi.org/10.1039/d0md00074dTest
http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00074DTest

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4

دورية أكاديمية

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest; Tucker, Julie Ann orcid.org/0000-0002-6119-676X , Myers, Stephanie M., Miller, Duncan C. et al. (27 more authors) (2019) Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. European Journal of Medicinal Chemistry. pp. 530-543. ISSN 0223-5234

الإتاحة: https://doi.org/10.1016/j.ejmech.2019.05.057Test
https://eprints.whiterose.ac.uk/148098Test/
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest

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5

دورية أكاديمية

Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF‐7 human breast cancer cells

المؤلفون: Lavie, Yaakov, Zhang, Zu‐chuan, Cao, Hui‐ting, Han, Tie‐Yan, Jones, Ralph C., Liu, Yong‐Yu, Jarman, Michael, Hardcastle, Ian R., Giuliano, Armando E., Cabot, Myles C.

المصدر: 1998-09-11. 77(6)

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6c58t942Test

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6

دورية أكاديمية

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach

المؤلفون: Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine

المساهمون: Cancer Research UK

المصدر: Organic & Biomolecular Chemistry ; volume 16, issue 11, page 1843-1850 ; ISSN 1477-0520 1477-0539

الإتاحة: https://doi.org/10.1039/c8ob00099aTest
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00099ATest

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7

دورية أكاديمية

Human Toxicity Caused by Indole and Indazole Carboxylate Synthetic Cannabinoid Receptor Agonists: From Horizon Scanning to Notification

المؤلفون: Hill, Simon L, Dunn, Michael, Cano, Céline, Harnor, Suzannah J, Hardcastle, Ian R, Grundlingh, Johann, Dargan, Paul I, Wood, David M, Tucker, Simon, Bartram, Thomas, Thomas, Simon H L

المساهمون: Public Health England

المصدر: Clinical Chemistry ; volume 64, issue 2, page 346-354 ; ISSN 0009-9147 1530-8561

مصطلحات موضوعية: Biochemistry (medical), Clinical Biochemistry

الإتاحة: https://doi.org/10.1373/clinchem.2017.275867Test
http://academic.oup.com/clinchem/article-pdf/64/2/346/32642105/clinchem0346.pdfTest

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8

دورية أكاديمية

TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation

المؤلفون: Drummond, Catherine J, Esfandiari, Arman, Liu, Junfeng, Lu, Xiaohong, Hutton, Claire, Jackson, Jennifer, Bennaceur, Karim, Xu, Qing, Makimanejavali, Aditya Rao, DEL BELLO, FABIO, PIERGENTILI, Alessandro, Newell, David R, Hardcastle, Ian R, Griffin, Roger J, Lunec, John

المساهمون: Drummond, Catherine J, Esfandiari, Arman, Liu, Junfeng, Lu, Xiaohong, Hutton, Claire, Jackson, Jennifer, Bennaceur, Karim, Xu, Qing, Makimanejavali, Aditya Rao, DEL BELLO, Fabio, Piergentili, Alessandro, Newell, David R, Hardcastle, Ian R, Griffin, Roger J, Lunec, John

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000385402300104; volume:7; firstpage:46203; lastpage:46218; numberofpages:16; journal:ONCOTARGET; http://hdl.handle.net/11581/394236Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84979910691; http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&pathTest[]=10073&path[]=32713

الإتاحة: https://doi.org/10.18632/oncotarget.10073Test
http://hdl.handle.net/11581/394236Test
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&pathTest[]=10073&path[]=32713

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