دورية أكاديمية
The effect of renal denervation on arterial stiffness, central blood pressure and heart rate variability in treatment resistant essential hypertension: a substudy of a randomized sham-controlled double-blinded trial (the ReSET trial)
| العنوان: | The effect of renal denervation on arterial stiffness, central blood pressure and heart rate variability in treatment resistant essential hypertension: a substudy of a randomized sham-controlled double-blinded trial (the ReSET trial) |
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| المؤلفون: | Christian Daugaard Peters, Ole Norling Mathiassen, Henrik Vase, Jesper Bech Nørgaard, Kent Lodberg Christensen, Anne Pauline Schroeder, Hans Joachim von Hofe Rickers, Ulla Kampmann Opstrup, Per Løgstrup Poulsen, Sten Langfeldt, Gratien Andersen, Klavs Würgler Hansen, Hans Erik Bøtker, Morten Engholm, Jannik Buus Bertelsen, Erling Bjerregaard Pedersen, Anne Kaltoft, Niels Henrik Buus |
| المصدر: | Blood Pressure, Vol 26, Iss 6, Pp 366-380 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | renal denervation, randomized controlled trial, arterial stiffness, pulse wave velocity, central blood pressure, heart rate variability, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Objectives: To investigate, whether renal denervation (RDN) improves arterial stiffness, central blood pressure (C-BP) and heart rate variability (HRV) in patients with treatment resistant hypertension. Methods: ReSET was a randomized, sham-controlled, double-blinded trial (NCT01459900). RDN was performed by a single experienced operator using the Medtronic unipolar Symplicity FlexTM catheter. C-BP, carotid-femoral pulse wave velocity (PWV), and HRV were obtained at baseline and after six months with the SphygmoCor®-device. Results: Fifty-three patients (77% of the ReSET-cohort) were included in this substudy. The groups were similar at baseline (SHAM/RDN): n = 27/n = 26; 78/65% males; age 59 ± 9/54 ± 8 years (mean ± SD); systolic brachial BP 158 ± 18/154 ± 17 mmHg; systolic 24-hour ambulatory BP 153 ± 14/151 ± 13 mmHg. Changes in PWV (0.1 ± 1.9 (SHAM) vs. −0.6 ± 1.3 (RDN) m/s), systolic C-BP (−2 ± 17 (SHAM) vs. −8 ± 16 (RDN) mmHg), diastolic C-BP (−2 ± 9 (SHAM) vs. −5 ± 9 (RDN) mmHg), and augmentation index (0.7 ± 7.0 (SHAM) vs. 1.0 ± 7.4 (RDN) %) were not significantly different after six months. Changes in HRV-parameters were also not significantly different. Baseline HRV or PWV did not predict BP-response after RDN. Conclusions: In a sham-controlled setting, there were no significant effects of RDN on arterial stiffness, C-BP and HRV. Thus, the idea of BP-independent effects of RDN on large arteries and cardiac autonomic activity is not supported. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0803-7051 1651-1999 08037051 |
| العلاقة: | https://doaj.org/toc/0803-7051Test; https://doaj.org/toc/1651-1999Test |
| DOI: | 10.1080/08037051.2017.1368368 |
| الوصول الحر: | https://doaj.org/article/7d24a772cee14ad5b1b88ae1cf830569Test |
| رقم الانضمام: | edsdoj.7d24a772cee14ad5b1b88ae1cf830569 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 08037051 16511999 |
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| DOI: | 10.1080/08037051.2017.1368368 |