MEN1-Dependent Breast Cancer
| العنوان: | MEN1-Dependent Breast Cancer |
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| المؤلفون: | Peter H. Bisschop, Petra H.M. Peeters, Hanneke J Beijers, Margreet G. E. M. Ausems, Ruud M. Pijnappel, Wouter W. de Herder, Olaf M. Dekkers, Bas Havekes, Anouk N A van der Horst-Schrivers, Gerlof D. Valk, Menno R. Vriens, Rachel S van Leeuwaarde, Madeleine L. Drent, Koen M.A. Dreijerink |
| المساهمون: | Internal Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Movement Sciences, Endocrinology, Clinical Neuropsychology, IBBA, AGEM - Endocrinology, metabolism and nutrition, Internal medicine, CCA - Cancer Treatment and quality of life, Interne Geneeskunde, MUMC+: MA Endocrinologie (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - R1 - Metabolic Syndrome, Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| المصدر: | Journal of Clinical Endocrinology and Metabolism, 102(6), 2083-2090. Endocrine Society Journal of clinical endocrinology and metabolism, 102(6), 2083-2090. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 102(6), 2083-2090 Journal of Clinical Endocrinology and Metabolism, 102(6), 2083-2090. Oxford University Press Journal of Clinical Endocrinology and Metabolism, 102(6), 2083-2090. The Endocrine Society Journal of Clinical Endocrinology & Metabolism, 102(6), 2083-2090. Oxford University Press van Leeuwaarde, R S, Dreijerink, K M, Ausems, M G, Beijers, H J, Dekkers, O M, de Herder, W W, van der Horst-Schrivers, A N, Drent, M L, Bisschop, P H, Havekes, B, Peeters, P H M, Pijnappel, R M, Vriens, M R & Valk, G D 2017, ' MEN1-Dependent Breast Cancer : Indication for Early Screening? Results From the Dutch MEN1 Study Group ', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 6, pp. 2083-2090 . https://doi.org/10.1210/jc.2016-3690Test Journal of Clinical Endocrinology and Metabolism, 102(6), 2083-2090. ENDOCRINE SOC Van Leeuwaarde, R S, Dreijerink, K M, Ausems, M G, Beijers, H J, Dekkers, O M, De Herder, W W, Van Der Horst-Schrivers, A N, Drent, M L, Bisschop, P H, Havekes, B, Peeters, P H M, Pijnappel, R M, Vriens, M R & Valk, G D 2017, ' MEN1-dependent breast cancer : Indication for early screening? Results from the Dutch MEN1 study group ', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 6, pp. 2083-2090 . https://doi.org/10.1210/jc.2016-3690Test |
| بيانات النشر: | ENDOCRINE SOC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Biochemistry, Breast cancer screening, 0302 clinical medicine, Endocrinology, Risk Factors, Epidemiology of cancer, BRCA2 MUTATION CARRIERS, 1114 Paediatrics And Reproductive Medicine, 80 and over, Age of Onset, skin and connective tissue diseases, Early Detection of Cancer, Netherlands, ENDOCRINE NEOPLASIA TYPE-1, Aged, 80 and over, RISK, education.field_of_study, medicine.diagnostic_test, Middle Aged, 030220 oncology & carcinogenesis, Female, SMOKING, Mammography, Adult, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system, PENETRANCE, Population, Breast Neoplasms, 03 medical and health sciences, Endocrinology & Metabolism, Breast cancer, SDG 3 - Good Health and Well-being, Internal medicine, BENEFITS, medicine, Journal Article, Multiple Endocrine Neoplasia Type 1, Cancer Family, Humans, Genetic Predisposition to Disease, education, Aged, NONCARRIERS, SELECTION BIAS, business.industry, MORTALITY, Biochemistry (medical), Case-control study, 1103 Clinical Sciences, medicine.disease, 030104 developmental biology, Cross-Sectional Studies, Case-Control Studies, HARMS, Mutation, Age of onset, business |
| الوصف: | Objective: Multiple Endocrine Neoplasia type 1 (MEN1) is associated with an early onset elevated breast cancer risk. This finding potentially has implications for breast cancer screening for females with MEN1. Considering the impact for females with MEN1, regarding distress and anxiety, it is necessary to assess if other risk factors are involved to identify those at greatest risk. Design: A cross-sectional case control study was performed using the Dutch MEN1 cohort, including >90% of the Dutch MEN1 population of 18 years and older. All females with a confirmed MEN1 mutation received a questionnaire regarding breast cancer related endocrine risk factors, cancer family history and other known risk factors for breast cancer. Results: A total of 138 of 165 (84%) eligible females with MEN1 completed the questionnaire. Eleven of the 138 females had breast cancer. Another 34 relatives with breast cancer were identified in the families of the included females, of whom 11 were obligate MEN1 carriers, 14 had no MEN1 mutation and nine had an unknown MEN1 status. The median age at breast cancer diagnosis of females with MEN1 (n=22) was 45 (range 30-80) years in comparison with 57.5 (range 40-85) years in female relatives without MEN1 (n= 14) (p=0.03) and 61.2 years in the Dutch reference population. Known endocrine risk factors as age at menarche, oral contraception use, pregnancy, age at first birth, parity and breast-feeding were not different for females with and without breast cancer. In addition, smoking and alcohol consumption did not differ between respondents with and without breast cancer. Conclusion: The increased breast cancer risk in MEN1 carriers was not related to other known breast cancer risk factors or familial cancer history and therefore breast cancer surveillance from the age of 40 years for all females with the MEN1 is justifiable. |
| اللغة: | English |
| تدمد: | 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2e27b65278340cdb412aff4e724575Test https://doi.org/10.1210/jc.2016-3690Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....db2e27b65278340cdb412aff4e724575 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0021972X |
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