Herpes Simplex Virus Keratitis Reactivation after SARS-CoV-2 BNT162b2 mRNA Vaccination: A Report of Two Cases
| العنوان: | Herpes Simplex Virus Keratitis Reactivation after SARS-CoV-2 BNT162b2 mRNA Vaccination: A Report of Two Cases |
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| المؤلفون: | Haneen E Alsobki, Haifa M Alwael, Abdullah Al Fawaz, Muhannad I. Alkhalifah, Hani S. Al-Mezaine |
| المصدر: | Ocular Immunology and Inflammation. 29:1238-1240 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Acyclovir, Herpesvirus 1, Human, medicine.disease_cause, Antiviral Agents, Polymerase Chain Reaction, Keratitis, medicine, Humans, Immunology and Allergy, BNT162 Vaccine, Endotheliitis, Messenger RNA, SARS-CoV-2, business.industry, Vaccination, COVID-19, medicine.disease, Dermatology, Ophthalmology, Herpes simplex virus, Keratitis, Herpetic, Latent Infection, Female, business, Epithelial keratitis |
| الوصف: | Purpose To report two cases of herpes simplex virus keratitis reactivation following Pfizer-BioNTech COVID-19 (BNT162b2) mRNA vaccination. Methods Two patients (one male, age 42 years, and one female, age 29 years) who are known to have herpetic keratitis presented to our emergency room in a time frame between 4 days and 4 weeks of receiving the vaccine. One patient presented with necrotizing stromal keratitis; the other presented with endotheliitis and epithelial keratitis. PCR for herpes simplex virus (HSV) was obtained from the two patients, and all cases received systemic acyclovir. Results PCR for HSV came positive in both cases. Patients responded well to the provided treatment. Conclusion Ocular herpetic infection may be activated by COVID-19 (BNT162b2) mRNA vaccine. Treating physician should be alert to such associations, and patients should be followed closely. No direct causality has been proven, but further reporting and investigating similar conditions is recommended. |
| تدمد: | 1744-5078 0927-3948 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb4f7d7893bf15aa10ef56de903b6d7Test https://doi.org/10.1080/09273948.2021.1986548Test |
| رقم الانضمام: | edsair.doi.dedup.....7fb4f7d7893bf15aa10ef56de903b6d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17445078 09273948 |
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