نتائج البحث - "Hakkarainen, Antti"

1

دورية أكاديمية

Matrisome alterations in obesity-Adipose tissue transcriptome study on monozygotic weight-discordant twins

المؤلفون: Kaartinen, Mari T., Hang, Anny, Barry, Amadou, Arora, Mansi, Heinonen, Sini, Lundbom, Jesper, Hakkarainen, Antti, Lundholm, Nina, Rissanen, Aila, Kaprio, Jaakko, Pietiläinen, Kirsi H.

المساهمون: CAMM - Research Program for Clinical and Molecular Metabolism, Research Programs Unit, HUS Abdominal Center, Endokrinologian yksikkö, Department of Medicine, University of Helsinki, Institute for Molecular Medicine Finland, Department of Public Health, Clinicum

وصف الملف: application/pdf

العلاقة: This work was supported by Canadian Institutes of Health Research (CIHR) grant to MTK from the (PJT-153089) . AH and AB were supported by McGill Initiative for Computational Medicine Research Match program. MA was a recipient of an internal stipend, Nyman Award, from the Faculty of Medicine of McGill University. SH was supported by Finnish Diabetes Research Foundation, Emil Aalto-nen Foundation, Finnish Medical Foundation, Maud Kuistila Foundation, Orion Foundation, Paulo foun-dation and Helsinki University Hospital funds. KHP is funded by the Academy of Finland, grant numbers 314383, 266286 and the Academy of Finland, Cen-tre of Excellence in Research on Mitochondria, Metabolism and Disease (FinMIT) , (grant number 272376) , Finnish Medical Foundation; Gyllenberg Foundation, Novo Nordisk Foundation (grant numbers NNF17OC0027232, NNF10OC1013354, NNF20OC0060547) , Finnish Diabetes Research Foundation, Finnish Foundation for Cardiovascular Research, University of Helsinki, Government Research Funds and Helsinki University Hospital.; Kaartinen , M T , Hang , A , Barry , A , Arora , M , Heinonen , S , Lundbom , J , Hakkarainen , A , Lundholm , N , Rissanen , A , Kaprio , J & Pietiläinen , K H 2022 , ' Matrisome alterations in obesity-Adipose tissue transcriptome study on monozygotic weight-discordant twins ' , Matrix Biology , vol. 108 , pp. 1-19 . https://doi.org/10.1016/j.matbio.2022.02.005Test; cf4ad6ce-ff8f-44c1-a15e-3e973b0e9d3d; http://hdl.handle.net/10138/569835Test; 000791288000001

الإتاحة: http://hdl.handle.net/10138/569835Test

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2

دورية أكاديمية

Deep learning neural network -guided detection of asbestos bodies in bronchoalveolar lavage samples

المؤلفون: Hakkarainen, Antti J., Randen-Brady, Reija, Wolff, Henrik, Mäyränpää, Mikko I., Sajantila, Antti

المساهمون: Department of Forensic Medicine, Department of Pathology, HUSLAB, Medicum, PaleOmics Laboratory

مصطلحات موضوعية: Asbestos, Asbestos bodies, Bronchoalveolar lavage, Deep learning, Neural network, Virtual microscopy, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: Hakkarainen , A J , Randen-Brady , R , Wolff , H , Mäyränpää , M I & Sajantila , A 2023 , ' Deep learning neural network -guided detection of asbestos bodies in bronchoalveolar lavage samples ' , Acta Cytologica , vol. 67 , no. 6 , pp. 650–658 . https://doi.org/10.1159/000534149Test; ORCID: /0000-0002-0877-9640/work/150698160; e5005e07-6fb5-457c-b08f-b2574ba620f3; http://hdl.handle.net/10138/569329Test; 001071445700001

الإتاحة: http://hdl.handle.net/10138/569329Test

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3

Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

المؤلفون: Luukkonen, Panu K., Qadri, Sami, Ahlholm, Noora, Porthan, Kimmo, Männistö, Ville, Sammalkorpi, Henna, Penttilä, Anne K., Hakkarainen, Antti, Lehtimäki, Tiina E., Gaggini, Melania, Gastaldelli, Amalia, Ala-Korpela, Mika, Orho-Melander, Marju, Arola, Johanna, Juuti, Anne, Pihlajamäki, Jussi, Hodson, Leanne, Yki-Järvinen, Hannele

المصدر: Journal of Hepatology EpiHealth: Epidemiology for Health EXODIAB: Excellence of Diabetes Research in Sweden. 76(3):526-535

مصطلحات موضوعية: adipose tissue lipolysis, de novo lipogenesis, hepatic mitochondrial redox state, HSD17B13, insulin resistance, MARC1, MBOAT7, metabolomics, PNPLA3, TM6SF2, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

الوصول الحر: https://lup.lub.lu.se/record/6eafb112-5323-4cc8-9779-09d8d0b0b232Test
http://dx.doi.org/10.1016/j.jhep.2021.10.013Test

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4

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue

المؤلفون: Qadri, Sami, Lallukka-Brück, Susanna, Luukkonen, Panu K., Zhou, You, Gastaldelli, Amalia, Orho-Melander, Marju, Sammalkorpi, Henna, Juuti, Anne, Penttilä, Anne K., Perttilä, Julia, Hakkarainen, Antti, Lehtimäki, Tiina E., Oresic, Matej, 1967, Hyötyläinen, Tuulia, 1971, Hodson, Leanne, Olkkonen, Vesa M., Yki-Järvinen, Hannele

المصدر: Liver international (Print). 40(9):2128-2138

مصطلحات موضوعية: Adipose tissue, fatty acids, lipidomics, lipolysis, non-alcoholic fatty liver disease, triglycerides

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81765Test
https://doi.org/10.1111/liv.14507Test

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5

دورية أكاديمية

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

المساهمون: Centre of Excellence in Stem Cell Metabolism, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Molecular and Integrative Biosciences Research Programme, Institute of Biotechnology, HUS Medical Imaging Center, Clinicum, HUS Abdominal Center, II kirurgian klinikka, Marja-Riitta Taskinen Research Group, Research Programs Unit, Department of Medicine, Per Henrik Groop / Principal Investigator, Medicum, Nefrologian yksikkö, Department of Biochemistry and Developmental Biology, Eija Pirinen / Principal Investigator

مصطلحات موضوعية: High-fat diet, Dna methylation, Skeletal-muscle, Adipose-tissue, Faecalibacterium-prausnitzii, Nad(+), Metabolism, Niacin, Liver, Supplementation, 3111 Biomedicine, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: Lapatto , H A K , Kuusela , M , Heikkinen , A , Muniandy , M , van der Kolk , B W , Gopalakrishnan , S , Pöllänen , N , Sandvik , M , Schmidt , M S , Heinonen , S , Saari , S , Kuula , J , Hakkarainen , A , Tampio , J , Saarinen , T , Taskinen , M-R , Lundbom , N , Groop , P-H , Tiirola , M , Katajisto , P , Lehtonen , M , Brenner , C , Kaprio , J , Pekkala , S , Ollikainen , M , Pietiläinen , K H & Pirinen , E 2023 , ' Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study ' , Science Advances , vol. 9 , no. 2 , eadd5163 . https://doi.org/10.1126/sciadv.add5163Test; ORCID: /0000-0002-6229-3588/work/127503841; ORCID: /0000-0003-3661-7400/work/127504093; ORCID: /0000-0002-5793-9196/work/127508370; ORCID: /0000-0001-8608-541X/work/127508859; ORCID: /0000-0003-2013-4420/work/128032715; ORCID: /0000-0002-3295-1260/work/133998104; 714d22d2-aa5a-4407-aee4-456b3290c766; http://hdl.handle.net/10138/353809Test; 000911464300022

الإتاحة: http://hdl.handle.net/10138/353809Test

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6

دورية أكاديمية

Effects of PNPLA3 I148M on hepatic lipid and very-low-density lipoprotein metabolism in humans

المؤلفون: Boren, Jan, Adiels, Martin, Björnson, Elias, Matikainen, Niina, Söderlund, Sanni, Rämö, Joel, Henricsson, Marcus, Ripatti, Pietari, Ripatti, Samuli, Palotie, Aarno, Mancina, Rosellina M., Ainola, Mari, Hakkarainen, Antti, Romeo, Stefano, Packard, Chris J., Taskinen, Marja-Riitta

المساهمون: HUS Abdominal Center, Clinicum, CAMM - Research Program for Clinical and Molecular Metabolism, Endokrinologian yksikkö, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Complex Disease Genetics, Helsinki Institute of Life Science HiLIFE, Samuli Olli Ripatti / Principal Investigator, Doctoral Programme in Social Sciences, Centre of Excellence in Complex Disease Genetics, Department of Public Health, Faculty Common Matters (Faculty of Social Sciences), Biostatistics Helsinki, Research Programs Unit, Aarno Palotie / Principal Investigator, INDIVIDRUG - Individualized Drug Therapy, HUS Internal Medicine and Rehabilitation, HUS Medical Imaging Center, Marja-Riitta Taskinen Research Group

مصطلحات موضوعية: triglycerides, lipid metabolism, lipoproteins, fatty liver, FATTY LIVER-DISEASE, OVERPRODUCTION, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: The authors thank the staff for excellent laboratory work and patient care. This project was funded by Swedish Heart-Lung Foundation, Swedish Research Council, ALF grant from the Sahlgrenska University Hospital, Sigrid Juselius Foundation, Helsinki University Hospital Government Research funds and Finnish Heart Foundation.; Boren , J , Adiels , M , Björnson , E , Matikainen , N , Söderlund , S , Rämö , J , Henricsson , M , Ripatti , P , Ripatti , S , Palotie , A , Mancina , R M , Ainola , M , Hakkarainen , A , Romeo , S , Packard , C J & Taskinen , M-R 2022 , ' Effects of PNPLA3 I148M on hepatic lipid and very-low-density lipoprotein metabolism in humans ' , Journal of internal medicine , vol. 291 , no. 2 , pp. 218-223 . https://doi.org/10.1111/joim.13375Test; ORCID: /0000-0002-2527-5874/work/127002310; ORCID: /0000-0003-2853-5851/work/127003656; ORCID: /0000-0002-6229-3588/work/127003790; ORCID: /0000-0003-0041-1240/work/127003848; ORCID: /0000-0002-6429-5149/work/127008462; 67213962-1c18-43e1-b4fe-cfb9bd4f48da; http://hdl.handle.net/10138/353351Test; 000699448900001

الإتاحة: http://hdl.handle.net/10138/353351Test

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7

دورية أكاديمية

Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease

المؤلفون: Driuchina, Anastasiia, Hintikka, Jukka, Lehtonen, Marko, Keski-Rahkonen, Pekka, O'Connell, Thomas, Juvonen, Risto, Kuula, Juho, Hakkarainen, Antti, Laukkanen, Jari A., Mäkinen, Elina, Lensu, Sanna, Pietiläinen, Kirsi H., Pekkala, Satu

المساهمون: HYKS erva, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, HUS Abdominal Center, Department of Medicine, Clinicum

مصطلحات موضوعية: Gut microbiota, Insulin resistance, Liver fat, Metabolomics, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: Driuchina , A , Hintikka , J , Lehtonen , M , Keski-Rahkonen , P , O'Connell , T , Juvonen , R , Kuula , J , Hakkarainen , A , Laukkanen , J A , Mäkinen , E , Lensu , S , Pietiläinen , K H & Pekkala , S 2023 , ' Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease ' , mBio , vol. 14 , no. 1 . https://doi.org/10.1128/mbio.02663-22Test; ORCID: /0000-0002-5793-9196/work/132083526; 43c2ec75-2a72-49aa-95bb-99561ff74b2b; http://hdl.handle.net/10138/356530Test; 000921708900001

الإتاحة: http://hdl.handle.net/10138/356530Test

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8

دورية أكاديمية

Contribution of intestinal triglyceride-rich lipoproteins to residual atherosclerotic cardiovascular disease risk in individuals with type 2 diabetes on statin therapy

المؤلفون: Taskinen, Marja-Riitta, Matikainen, Niina, Björnson, Elias, Söderlund, Sanni, Inkeri, Jussi, Hakkarainen, Antti, Parviainen, Helka, Sihlbom, Carina, Thorsell, Annika, Andersson, Linda, Adiels, Martin, Packard, Chris J., Boren, Jan

المساهمون: Clinicum, Marja-Riitta Taskinen Research Group, HUS Heart and Lung Center, Research Programs Unit, HUS Abdominal Center, Endokrinologian yksikkö, HUS Medical Imaging Center

مصطلحات موضوعية: Apolipoprotein B-100, Apolipoprotein B-48, Chylomicrons, Liver, Metabolism, Postprandial, Stable isotope, Vldl, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: Open access funding provided by University of Gothenburg.This project was funded by grants from the Swedish Heart-Lung Foundation, the Swedish Research Council, the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement, the Novo Nordisk Foundation, the Sigrid Juselius Foundation, Helsinki University Hospital Government Research funds, the Finnish Heart Foundation, the Finnish Diabetes Research Foundation and Diabetes Wellness; Taskinen , M-R , Matikainen , N , Björnson , E , Söderlund , S , Inkeri , J , Hakkarainen , A , Parviainen , H , Sihlbom , C , Thorsell , A , Andersson , L , Adiels , M , Packard , C J & Boren , J 2023 , ' Contribution of intestinal triglyceride-rich lipoproteins to residual atherosclerotic cardiovascular disease risk in individuals with type 2 diabetes on statin therapy ' , Diabetologia , vol. 66 , no. 12 , pp. 2307-2319 . https://doi.org/10.1007/s00125-023-06008-0Test; ORCID: /0000-0002-6229-3588/work/146904794; ORCID: /0000-0003-0041-1240/work/146905221; ORCID: /0000-0001-5799-0840/work/146911213; 1fb5b25e-86f1-46f1-8059-c9511f3a0ade; http://hdl.handle.net/10138/567110Test; 001077924300001

الإتاحة: http://hdl.handle.net/10138/567110Test

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