دورية أكاديمية
The effect of pregnant rat swimming on hypoxia-inducible factor-1α levels of neonatal lung
| العنوان: | The effect of pregnant rat swimming on hypoxia-inducible factor-1α levels of neonatal lung |
|---|---|
| المؤلفون: | Mirdar Shadmehr, Arab Anna, Hedayati Mehdi, Hajizade Akbar |
| المصدر: | Tehran University Medical Journal, Vol 69, Iss 12, Pp 754-760 (2012) |
| بيانات النشر: | Tehran University of Medical Sciences, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Embryo development, hypoxia-inducible factor 1 alpha, pregnant, swimming, training, Medicine (General), R5-920 |
| الوصف: | Background: Uterine environment and fetal period can profoundly affect health of the neonat. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that regulates cellular stress responses and its activity is essential in both embryogenesis and postnatal life. The aim of the present study was to investigate the effects of maternal swimming on rat pups' HIF-1α levels as a key regulator of oxygen in lungs. Methods: Sixteen female Wistar rats weighing 180- 200 grams were acclimated to a new environment consisting of equal light-darkness cycle and ad lib access to chow and adapted to the stress caused by water for two weeks. The rats were divided into two swimming and control groups. Swimming training began on the first day of pregnancy in a pool and continued for 3 weeks (1 h/day, 5 days/wk). Pups' lungs were removed two days after birth and their HIF-1α concentration was determined with enzyme-linked immunosorbent assay (ELISA). Statistical analysis of the data was done using independent t-test. A p-value smaller than 0.05 was considered statistically significant. Results: Swimming lead to a significant (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 1683-1764 1735-7322 |
| العلاقة: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-162&slc_lang=en&sid=1Test; https://doaj.org/toc/1683-1764Test; https://doaj.org/toc/1735-7322Test |
| الوصول الحر: | https://doaj.org/article/9a697c207bb14885b17da00256f3bbacTest |
| رقم الانضمام: | edsdoj.9a697c207bb14885b17da00256f3bbac |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16831764 17357322 |
|---|